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Next generation flow for minimally-invasive blood characterization of MGUS and multiple myeloma at diagnosis based on circulating tumor plasma cells (CTPC).

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dc.contributor.authorSanoja-Flores, L
dc.contributor.authorFlores-Montero, J
dc.contributor.authorGarcés, J J
dc.contributor.authorPaiva, B
dc.contributor.authorPuig, N
dc.contributor.authorGarcía-Mateo, A
dc.contributor.authorGarcía-Sánchez, O
dc.contributor.authorCorral-Mateos, A
dc.contributor.authorBurgos, L
dc.contributor.authorBlanco, E
dc.contributor.authorHernández-Martín, J
dc.contributor.authorPontes, R
dc.contributor.authorDíez-Campelo, M
dc.contributor.authorMillacoy, P
dc.contributor.authorRodríguez-Otero, P
dc.contributor.authorProsper, F
dc.contributor.authorMerino, J
dc.contributor.authorVidriales, M B
dc.contributor.authorGarcía-Sanz, R
dc.contributor.authorRomero, A
dc.contributor.authorPalomera, L
dc.contributor.authorRíos-Tamayo, R
dc.contributor.authorPérez-Andrés, M
dc.contributor.authorBlanco, J F
dc.contributor.authorGonzález, M
dc.contributor.authorvan Dongen, J J M
dc.contributor.authorDurie, B
dc.contributor.authorMateos, M V
dc.contributor.authorSan-Miguel, J
dc.contributor.authorOrfao, A
dc.contributor.authorEuroFlow consortium
dc.date.accessioned2023-01-25T10:24:44Z
dc.date.available2023-01-25T10:24:44Z
dc.date.issued2018-11-19
dc.description.abstractHere, we investigated for the first time the frequency and number of circulating tumor plasma cells (CTPC) in peripheral blood (PB) of newly diagnosed patients with localized and systemic plasma cell neoplasms (PCN) using next-generation flow cytometry (NGF) and correlated our findings with the distinct diagnostic and prognostic categories of the disease. Overall, 508 samples from 264 newly diagnosed PCN patients, were studied. CTPC were detected in PB of all active multiple myeloma (MM; 100%), and smoldering MM (SMM) patients (100%), and in more than half (59%) monoclonal gammopathy of undetermined significance (MGUS) cases (p 
dc.identifier.doi10.1038/s41408-018-0153-9
dc.identifier.essn2044-5385
dc.identifier.pmcPMC6242818
dc.identifier.pmid30455467
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242818/pdf
dc.identifier.unpaywallURLhttps://www.nature.com/articles/s41408-018-0153-9.pdf
dc.identifier.urihttp://hdl.handle.net/10668/13210
dc.issue.number12
dc.journal.titleBlood cancer journal
dc.journal.titleabbreviationBlood Cancer J
dc.language.isoen
dc.organizationHospital Universitario Virgen de las Nieves
dc.page.number117
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshBiomarkers
dc.subject.meshDiagnosis, Differential
dc.subject.meshFemale
dc.subject.meshFlow Cytometry
dc.subject.meshHumans
dc.subject.meshImmunophenotyping
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMonoclonal Gammopathy of Undetermined Significance
dc.subject.meshMultiple Myeloma
dc.subject.meshNeoplasm Staging
dc.subject.meshNeoplastic Cells, Circulating
dc.subject.meshPlasma Cells
dc.subject.meshPrognosis
dc.subject.meshSensitivity and Specificity
dc.titleNext generation flow for minimally-invasive blood characterization of MGUS and multiple myeloma at diagnosis based on circulating tumor plasma cells (CTPC).
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number8
dspace.entity.typePublication

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