Publication:
The Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg).

dc.contributor.authorCaldas, María
dc.contributor.authorPérez-Aisa, Ángeles
dc.contributor.authorTepes, Bojan
dc.contributor.authorKeco-Huerga, Alma
dc.contributor.authorBujanda, Luis
dc.contributor.authorLucendo, Alfredo J
dc.contributor.authorRodrigo, Luis
dc.contributor.authorVaira, Dino
dc.contributor.authorFernández-Salazar, Luis
dc.contributor.authorHuguet, Jose M
dc.contributor.authorPérez-Lasala, Jorge
dc.contributor.authorJurecic, Natasa Brglez
dc.contributor.authorFadeenko, Galina
dc.contributor.authorBarrio, Jesús
dc.contributor.authorAreia, Miguel
dc.contributor.authorOrtuño, Juan
dc.contributor.authorPellicano, Rinaldo
dc.contributor.authorLeja, Marcis
dc.contributor.authorMolina-Infante, Javier
dc.contributor.authorBogomolov, Pavel
dc.contributor.authorAlekseenko, Sergey
dc.contributor.authorDomínguez-Cajal, Manuel
dc.contributor.authorGómez-Camarero, Judith
dc.contributor.authorNtouli, Vassiliki
dc.contributor.authorMartínez-Domínguez, Samuel J
dc.contributor.authorRuiz-Zorrilla, Rafael
dc.contributor.authorNúñez, Oscar
dc.contributor.authorSarsenbaeva, Aiman Silkanovna
dc.contributor.authorAlmela, Pedro
dc.contributor.authorPhull, Perminder
dc.contributor.authorEspada, Marta
dc.contributor.authorPuig, Ignasi
dc.contributor.authorNyssen, Olga P
dc.contributor.authorMégraud, Francis
dc.contributor.authorO'Morain, Colm
dc.contributor.authorGisbert, Javier P
dc.contributor.authorthe Hp-EuReg Investigators
dc.date.accessioned2023-02-09T11:47:47Z
dc.date.available2023-02-09T11:47:47Z
dc.date.issued2021-08-11
dc.description.abstractStatins could increase the effectiveness of Helicobacter pylori eradication therapies due to their anti-inflammatory effect. The aim of this study was to analyze the impact of this therapeutic association in real life. This is a multicenter, prospective, non-interventional study aimed at evaluating the management of H. pylori by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap from 2013 to 2020. The association between statin use and H. pylori eradication effectiveness was evaluated through multivariate analysis. Overall, 9988 and 705 patients received empirical and culture-guided treatment, respectively. Overall, statin use was associated with higher effectiveness in the empirical group (OR = 1.3; 95%CI = 1.1-1.5), but no association was found with first-line treatment effectiveness (N = 7738); as an exception, statin use was specifically associated with lower effectiveness of standard triple therapy (OR = 0.76; 95%CI = 0.59-0.99). In the rescue therapy empirical group (N = 2228), statins were associated with higher overall effectiveness (OR = 1.9; 95%CI = 1.4-2.6). However, sub-analyses by treatment schemes only confirmed this association for the single-capsule bismuth quadruple therapy (OR = 2.8; 95%CI = 1.3-5.7). No consistent association was found between statin use and H. pylori therapy effectiveness. Therefore, the addition of statins to the usual H. pylori treatment cannot be currently recommended to improve cure rates.
dc.identifier.doi10.3390/antibiotics10080965
dc.identifier.issn2079-6382
dc.identifier.pmcPMC8388917
dc.identifier.pmid34439015
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388917/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2079-6382/10/8/965/pdf?version=1628748489
dc.identifier.urihttp://hdl.handle.net/10668/18414
dc.issue.number8
dc.journal.titleAntibiotics (Basel, Switzerland)
dc.journal.titleabbreviationAntibiotics (Basel)
dc.language.isoen
dc.organizationHospital Costa del Sol
dc.organizationÁrea de Gestión Sanitaria Sur de Sevilla
dc.organizationAGS - Sur de Sevilla
dc.pubmedtypeJournal Article
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHelicobacter pylori
dc.subjectstatins
dc.subjecttreatment
dc.titleThe Role of Statins on Helicobacter pylori Eradication: Results from the European Registry on the Management of H. pylori (Hp-EuReg).
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication

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