Publication: Clinical and pathological characteristics of peripheral T-cell lymphomas in a Spanish population: a retrospective study.
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Identifiers
Date
2020-05-19
Authors
Rodriguez-Pinilla, Socorro Maria
Domingo-Domenech, Eva
Climent, Fina
Sanchez, Joaquin
Perez-Seoane, Carlos
Lopez-Jimenez, Javier
Garcia-Cosio, Monica
Caballero, Dolores
Blanco-Muñez, Oscar Javier
Carpio, Cecilia
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley-Blackwell Publishing Ltd.
Abstract
We investigated the clinicopathological features and prognostic factors of patients with peripheral T-cell lymphoma (PTCL) in 13 sites across Spain. Relevant clinical antecedents, CD30 expression and staining pattern, prognostic indices using the International Prognostic Index and the Intergruppo Italiano Linfomi system, treatments, and clinical outcomes were examined. A sizeable proportion of 175 patients had a history of immune-related disorders (autoimmune 16%, viral infections 17%, chemo/radiotherapy-treated carcinomas 19%). The median progression-free survival (PFS) and overall survival (OS) were 7·9 and 15·8 months, respectively. Prognostic indices influenced PFS and OS, with a higher number of adverse factors resulting in shorter survival (P 15% of cells were positive in anaplastic lymphoma kinase-positive and -negative anaplastic large-cell lymphoma and extranodal natural killer PTCL groups. We observed PTCL distribution across subtypes based on haematopathological re-evaluation. Poor prognosis, effect of specific prognostic indices, relevance of histopathological sub-classification, and response level to first-line treatment on outcomes were confirmed. Immune disorders amongst patients require further examination involving genetic studies and identification of associated immunosuppressive factors.
Description
MeSH Terms
Adolescent
Adult
Aged
Aged, 80 and over
Female
Humans
Ki-1 Antigen
Lymphoma, T-Cell, Peripheral
Male
Middle Aged
Prognosis
Retrospective Studies
Spain
Survival Analysis
Young Adult
Adult
Aged
Aged, 80 and over
Female
Humans
Ki-1 Antigen
Lymphoma, T-Cell, Peripheral
Male
Middle Aged
Prognosis
Retrospective Studies
Spain
Survival Analysis
Young Adult
DeCS Terms
Pacientes
Pronóstico
Sobrevida
Virosis
Linfoma Anaplásico de Células Grandes
Quinasa de Linfoma Anaplásico
Carcinoma
Clasificación
Pronóstico
Sobrevida
Virosis
Linfoma Anaplásico de Células Grandes
Quinasa de Linfoma Anaplásico
Carcinoma
Clasificación
CIE Terms
Keywords
anaplastic large-cell lymphoma, anaplastic lymphoma kinase, complete response, overall survival, peripheral T-cell lymphoma, progression-free survival
Citation
Rodriguez-Pinilla SM, Domingo-Domenech E, Climent F, Sanchez J, Perez Seoane C, Lopez Jimenez J, et al. Clinical and pathological characteristics of peripheral T-cell lymphomas in a Spanish population: a retrospective study. Br J Haematol. 2021 Jan;192(1):82-99.