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You might owe your mother more than you think.

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dc.contributor.authorde-Las-Vecillas, Leticia
dc.contributor.authorEguiluz-Gracia, Ibon
dc.contributor.authorGiovannini, Mattia
dc.contributor.funderInstituto de Salud Carlos III of the Spanish Ministry of Science and Competitiveness
dc.contributor.funderEuropean Regional Development Fund through the research contract “Juan Rodes”
dc.contributor.funderRedes Temáticas de Investigación Colaborativa en Salud (RETICS)
dc.contributor.funderAsma, Reacciones Adversas y Alérgicas-ARADyAL
dc.date.accessioned2023-02-09T10:51:24Z
dc.date.available2023-02-09T10:51:24Z
dc.date.issued2021-04-08
dc.description.abstractImmunoglobulin E (IgE)–mediated activation of mast cells (MC) has been historically linked to allergic reactions. Nevertheless, antibody-dependent MC degranulation can also be triggered by venoms from insects or reptiles. Of note, MC mediators provide efficient protection against the toxic compounds of venoms. Interestingly, antigen-specific (s) IgE-dependent MC activation could occur in newborns who are not able yet to mount functional antibody responses. In a recent article, Msallam et al. investigated the interactions among fetal MC, maternal sIgE, and fetal immune responses in mice and humans. Mouse fetal MC acquire a semi-mature phenotype according to their FcεRI and heparin expression levels, and increase in number during early development stages.
dc.description.sponsorshipThis work was supported by the Instituto de Salud Carlos III of the Spanish Ministry of Science and Competitiveness (grants co-funded by theEuropean Regional Development Fund) through the research contract “Juan Rodes” for IEG (JR19/00029), and the program of RedesTemáticas deInvestigaciónColaborativaenSalud (RETICS): Asma, ReaccionesAdversas y Alérgicas-ARADyAL (RD16/0006/0001).
dc.description.versionSi
dc.identifier.citationde Las Vecillas L, Eguiluz-Gracia I, Giovannini M. You might owe your mother more than you think. Allergy. 2021 Oct;76(10):3236-3237
dc.identifier.doi10.1111/all.14855
dc.identifier.essn1398-9995
dc.identifier.pmid33840097
dc.identifier.unpaywallURLhttps://doi.org/10.22541/au.161401667.74000077/v1
dc.identifier.urihttp://hdl.handle.net/10668/17560
dc.issue.number10
dc.journal.titleAllergy
dc.journal.titleabbreviationAllergy
dc.language.isoen
dc.organizationHospital Universitario Regional de Málaga
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number3236-3237
dc.provenanceRealizada la curación de contenido 24/02/2025
dc.publisherWiley
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.pubmedtypeComment
dc.relation.projectIDJR19/00029
dc.relation.projectIDRD16/0006/0001
dc.relation.publisherversionhttps://doi.org/10.1111/all.14855
dc.rights.accessRightsRestricted Access
dc.subjectIgE
dc.subjectMast cells
dc.subjectProtection
dc.subjectToxin hypothesis
dc.subjectTransplacental transfer
dc.subject.decsInmunoglobulina E
dc.subject.decsRecién nacido
dc.subject.decsInsectos
dc.subject.decsInmunidad
dc.subject.decsHeparina
dc.subject.decsHipersensibilidad
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMothers
dc.subject.meshImmunoglobulin E
dc.subject.meshHypersensitivity
dc.subject.meshAllergens
dc.titleYou might owe your mother more than you think.
dc.typeresearch article
dc.type.hasVersionSMUR
dc.volume.number76
dspace.entity.typePublication

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