Publication: The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration.
dc.contributor.author | Díaz Del Moral, Sandra | |
dc.contributor.author | Benaouicha, Maha | |
dc.contributor.author | Muñoz-Chápuli, Ramón | |
dc.contributor.author | Carmona, Rita | |
dc.contributor.funder | Spanish Ministry of Economy, Industry and Competitivity | |
dc.contributor.funder | Consejería de Salud, Junta de Andalucía | |
dc.contributor.funder | Instituto de Salud Carlos III-TERCEL network | |
dc.contributor.funder | Consejería de Economía y Conocimiento, Junta de Andalucía | |
dc.date.accessioned | 2023-05-03T14:00:02Z | |
dc.date.available | 2023-05-03T14:00:02Z | |
dc.date.issued | 2021-12-26 | |
dc.description.abstract | Insulin and Insulin-like growth factors (IGFs) perform key roles during embryonic development, regulating processes of cell proliferation and survival. The IGF signalling pathway comprises two IGFs (IGF1, IGF2), two IGF receptors (IGFR1, IGFR2), and six IGF binding proteins (IGFBPs) that regulate IGF transport and availability. The IGF signalling pathway is essential for cardiac development. IGF2 is the primary mitogen inducing ventricular cardiomyocyte proliferation and morphogenesis of the compact myocardial wall. Conditional deletion of the Igf1r and the insulin receptor (Insr) genes in the myocardium results in decreased cardiomyocyte proliferation and ventricular wall hypoplasia. The significance of the IGF signalling pathway during embryonic development has led to consider it as a candidate for adult cardiac repair and regeneration. In fact, paracrine IGF2 plays a key role in the transient regenerative ability of the newborn mouse heart. We aimed to review the current knowledge about the role played by the IGF signalling pathway during cardiac development and also the clinical potential of recapitulating this developmental axis in regeneration of the adult heart. | |
dc.description.sponsorship | This research was funded by Spanish Ministry of Economy, Industry and Competitivity (BFU2017-83907-P to R.M.C., R.C), Consejería de Salud, Junta de Andalucía (PC0066-2017/PC-0081-2017 to R.C.), Instituto de Salud Carlos III-TERCEL network (RD16/0011/0030 to R.M.C., R.C.), Consejería de Economía y Conocimiento, Junta de Andalucía (UMA18-FEDERJA-146 to R.M.C., R.C.). | |
dc.description.version | Sí | |
dc.identifier.citation | Díaz Del Moral S, Benaouicha M, Muñoz-Chápuli R, Carmona R. The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration. Int J Mol Sci. 2021;23(1):234. Published 2021 Dec 26. | |
dc.identifier.doi | 10.3390/ijms23010234 | |
dc.identifier.essn | 1422-0067 | |
dc.identifier.issn | 1422-0067 | |
dc.identifier.pmc | PMC8745665 | |
dc.identifier.pmid | 35008660 | |
dc.identifier.pubmedURL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745665/pdf | |
dc.identifier.unpaywallURL | https://www.mdpi.com/1422-0067/23/1/234/pdf?version=1640676974 | |
dc.identifier.uri | http://hdl.handle.net/10668/21126 | |
dc.issue.number | 1 | |
dc.journal.title | International journal of molecular sciences | |
dc.journal.titleabbreviation | Int J Mol Sci | |
dc.language.iso | en | |
dc.organization | Centro Andaluz de Nanomedicina y Biotecnología-BIONAND | |
dc.organization | Instituto de Investigación Biomédica de Málaga-IBIMA | |
dc.page.number | 11 | |
dc.provenance | Realizada la curación de contenido 06/06/2025 | |
dc.publisher | Mdpi | |
dc.pubmedtype | Review | |
dc.relation.projectID | BFU2017-83907-P | |
dc.relation.projectID | PC0066-2017/PC-0081-2017 | |
dc.relation.projectID | RD16/0011/0030 | |
dc.relation.projectID | UMA18-FEDERJA-146 | |
dc.relation.publisherversion | https://www.mdpi.com/1423146 | |
dc.rights | Attribution 4.0 International | |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | heart development | |
dc.subject | insulin-like growth factor receptors | |
dc.subject | insulin-like growth factors | |
dc.subject | myocardial proliferation | |
dc.subject.decs | Desarrollo Embrionario | |
dc.subject.decs | Receptor de Insulina | |
dc.subject.decs | Corazón | |
dc.subject.decs | Miocitos Cardíacos | |
dc.subject.decs | Péptidos Similares a la Insulina | |
dc.subject.decs | Miocardio | |
dc.subject.decs | Proteínas de Unión a Factor de Crecimiento Similar a la Insulina | |
dc.subject.decs | Mitógenos | |
dc.subject.decs | Morfogénesis | |
dc.subject.decs | Proliferación Celular | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Heart | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Insulin-Like Growth Factor Binding Proteins | |
dc.subject.mesh | Morphogenesis | |
dc.subject.mesh | Myocardium | |
dc.subject.mesh | Receptor, IGF Type 1 | |
dc.subject.mesh | Receptor, IGF Type 2 | |
dc.subject.mesh | Regeneration | |
dc.subject.mesh | Signal Transduction | |
dc.subject.mesh | Somatomedins | |
dc.title | The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration. | |
dc.type | review | |
dc.type.hasVersion | VoR | |
dc.volume.number | 23 | |
dspace.entity.type | Publication |
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