Publication:
The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration.

dc.contributor.authorDíaz Del Moral, Sandra
dc.contributor.authorBenaouicha, Maha
dc.contributor.authorMuñoz-Chápuli, Ramón
dc.contributor.authorCarmona, Rita
dc.contributor.funderSpanish Ministry of Economy, Industry and Competitivity
dc.contributor.funderConsejería de Salud, Junta de Andalucía
dc.contributor.funderInstituto de Salud Carlos III-TERCEL network
dc.contributor.funderConsejería de Economía y Conocimiento, Junta de Andalucía
dc.date.accessioned2023-05-03T14:00:02Z
dc.date.available2023-05-03T14:00:02Z
dc.date.issued2021-12-26
dc.description.abstractInsulin and Insulin-like growth factors (IGFs) perform key roles during embryonic development, regulating processes of cell proliferation and survival. The IGF signalling pathway comprises two IGFs (IGF1, IGF2), two IGF receptors (IGFR1, IGFR2), and six IGF binding proteins (IGFBPs) that regulate IGF transport and availability. The IGF signalling pathway is essential for cardiac development. IGF2 is the primary mitogen inducing ventricular cardiomyocyte proliferation and morphogenesis of the compact myocardial wall. Conditional deletion of the Igf1r and the insulin receptor (Insr) genes in the myocardium results in decreased cardiomyocyte proliferation and ventricular wall hypoplasia. The significance of the IGF signalling pathway during embryonic development has led to consider it as a candidate for adult cardiac repair and regeneration. In fact, paracrine IGF2 plays a key role in the transient regenerative ability of the newborn mouse heart. We aimed to review the current knowledge about the role played by the IGF signalling pathway during cardiac development and also the clinical potential of recapitulating this developmental axis in regeneration of the adult heart.
dc.description.sponsorshipThis research was funded by Spanish Ministry of Economy, Industry and Competitivity (BFU2017-83907-P to R.M.C., R.C), Consejería de Salud, Junta de Andalucía (PC0066-2017/PC-0081-2017 to R.C.), Instituto de Salud Carlos III-TERCEL network (RD16/0011/0030 to R.M.C., R.C.), Consejería de Economía y Conocimiento, Junta de Andalucía (UMA18-FEDERJA-146 to R.M.C., R.C.).
dc.description.version
dc.identifier.citationDíaz Del Moral S, Benaouicha M, Muñoz-Chápuli R, Carmona R. The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration. Int J Mol Sci. 2021;23(1):234. Published 2021 Dec 26.
dc.identifier.doi10.3390/ijms23010234
dc.identifier.essn1422-0067
dc.identifier.issn1422-0067
dc.identifier.pmcPMC8745665
dc.identifier.pmid35008660
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8745665/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/1422-0067/23/1/234/pdf?version=1640676974
dc.identifier.urihttp://hdl.handle.net/10668/21126
dc.issue.number1
dc.journal.titleInternational journal of molecular sciences
dc.journal.titleabbreviationInt J Mol Sci
dc.language.isoen
dc.organizationCentro Andaluz de Nanomedicina y Biotecnología-BIONAND
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number11
dc.provenanceRealizada la curación de contenido 06/06/2025
dc.publisherMdpi
dc.pubmedtypeReview
dc.relation.projectIDBFU2017-83907-P
dc.relation.projectIDPC0066-2017/PC-0081-2017
dc.relation.projectIDRD16/0011/0030
dc.relation.projectIDUMA18-FEDERJA-146
dc.relation.publisherversionhttps://www.mdpi.com/1423146
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectheart development
dc.subjectinsulin-like growth factor receptors
dc.subjectinsulin-like growth factors
dc.subjectmyocardial proliferation
dc.subject.decsDesarrollo Embrionario
dc.subject.decsReceptor de Insulina
dc.subject.decsCorazón
dc.subject.decsMiocitos Cardíacos
dc.subject.decsPéptidos Similares a la Insulina
dc.subject.decsMiocardio
dc.subject.decsProteínas de Unión a Factor de Crecimiento Similar a la Insulina
dc.subject.decsMitógenos
dc.subject.decsMorfogénesis
dc.subject.decsProliferación Celular
dc.subject.meshAnimals
dc.subject.meshHeart
dc.subject.meshHumans
dc.subject.meshInsulin-Like Growth Factor Binding Proteins
dc.subject.meshMorphogenesis
dc.subject.meshMyocardium
dc.subject.meshReceptor, IGF Type 1
dc.subject.meshReceptor, IGF Type 2
dc.subject.meshRegeneration
dc.subject.meshSignal Transduction
dc.subject.meshSomatomedins
dc.titleThe Insulin-like Growth Factor Signalling Pathway in Cardiac Development and Regeneration.
dc.typereview
dc.type.hasVersionVoR
dc.volume.number23
dspace.entity.typePublication

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