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Breast cancer prognostic classification in the molecular era: the role of histological grade.

dc.contributor.authorRakha, Emad A.
dc.contributor.authorReis-Filho, Jorge S.
dc.contributor.authorBaehner, Frederick
dc.contributor.authorDabbs, David J.
dc.contributor.authorDecker, Thomas
dc.contributor.authorEusebi, Vincenzo
dc.contributor.authorFox, Stephen B.
dc.contributor.authorIchihara, Shu
dc.contributor.authorJacquemier, Jocelyne
dc.contributor.authorLakhani, Sunil R.
dc.contributor.authorPalacios, José
dc.contributor.authorRichardson, Andrea L.
dc.contributor.authorSchnitt, Stuart J.
dc.contributor.authorSchmitt, Fernando C.
dc.contributor.authorTan, Puay-Hoon
dc.contributor.authorTse, Gary M.
dc.contributor.authorBadve, Sunil
dc.contributor.authorEllis, Ian O.
dc.contributor.authoraffiliation[Rakha,EA; Ellis,IO] Department of Histopathology, Nottingham University Hospital NHS Trust, Nottingham, UK. [Reis-Filho,JS] The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK. [Baehner,F] Department of Anatomic Pathology, University of California, San Francisco, CA, USA. [Dabbs,DJ] University of Pittsburgh Medical Center, Pittsburgh, PA, USA. [Decker,T] Breast-Screening-Pathology, Reference Centre Munster, Gerhard Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany. [Eusebi,V] Sezione Anatomia Istologia e Citologia Patologica 'M. Malpighi', Università-ASL Ospedale Bellaria, Bologna, Italia. [Fox,SF] Pathology Department, Peter MacCallum Cancer Centre, East Melbourne, Victoria , Australia. [Ichihara,S] Department of Pathology, Nagoya Medical Center, Naka-ku, Nagoya Japan. [Jacquemier,J] Unité d'Anatomie et de Cytologie Pathologiques, Institut Paoli-Calmettes, Marseille, France. [Lakhani,SR] Molecular and Cellular Pathology, The University of Queensland, Mayne Medical School, Brisbane, Australia. [Palacios,J] Servicio de Anatomía Patológica, Hospital Universitario Virgen del Rocio, Sevilla, Spain. [Richardson,AL] Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA. [Schnitt,SJ] Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. [Schmitt,FC] Institute of Molecular Pathology and Immunology (IPATIMUP) and Medical Faculty, University of Porto, Porto, Portugal. [Tan,P-H] Department of Pathology, Singapore General Hospital, Singapore. [Tse,GM] Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Shatin, Hong Kong. [Badve,S] Departments of Pathology and Internal Medicine, Clarian Pathology Lab of Indiana University, Indianapolis, USA.es
dc.date.accessioned2015-07-08T10:28:01Z
dc.date.available2015-07-08T10:28:01Z
dc.date.issued2010-07-30
dc.descriptionJournal Article; Review;es
dc.description.abstractBreast cancer is a heterogeneous disease with varied morphological appearances, molecular features, behavior, and response to therapy. Current routine clinical management of breast cancer relies on the availability of robust clinical and pathological prognostic and predictive factors to support clinical and patient decision making in which potentially suitable treatment options are increasingly available. One of the best-established prognostic factors in breast cancer is histological grade, which represents the morphological assessment of tumor biological characteristics and has been shown to be able to generate important information related to the clinical behavior of breast cancers. Genome-wide microarray-based expression profiling studies have unraveled several characteristics of breast cancer biology and have provided further evidence that the biological features captured by histological grade are important in determining tumor behavior. Also, expression profiling studies have generated clinically useful data that have significantly improved our understanding of the biology of breast cancer, and these studies are undergoing evaluation as improved prognostic and predictive tools in clinical practice. Clinical acceptance of these molecular assays will require them to be more than expensive surrogates of established traditional factors such as histological grade. It is essential that they provide additional prognostic or predictive information above and beyond that offered by current parameters. Here, we present an analysis of the validity of histological grade as a prognostic factor and a consensus view on the significance of histological grade and its role in breast cancer classification and staging systems in this era of emerging clinical use of molecular classifiers.es
dc.description.versionYeses
dc.identifier.citationRakha EA, Reis-Filho JS, Baehner F, Dabbs DJ, Decker T, Eusebi V, et al. Breast cancer prognostic classification in the molecular era: the role of histological grade. Breast Cancer Res. 2010; 12(4):207es
dc.identifier.doi10.1186/bcr2607
dc.identifier.essn1465-542X
dc.identifier.issn1465-5411
dc.identifier.pmcPMC2949637
dc.identifier.pmid20804570
dc.identifier.urihttp://hdl.handle.net/10668/1923
dc.journal.titleBreast Cancer Research: BCR
dc.language.isoen
dc.publisherBIOMED CENTRAL LTDes
dc.relation.publisherversionhttp://breast-cancer-research.com/content/12/4/207/abstractes
dc.rights.accessRightsopen access
dc.subjectFemeninoes
dc.subjectPerfilación de la expresión génicaes
dc.subjectRegulación neoplásica de la expresión génicaes
dc.subjectGanglios linfáticoses
dc.subjectPronósticoes
dc.subject.meshMedical Subject Headings::Check Tags::Femalees
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profilinges
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Neoplastices
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Lymphoid Tissue::Lymph Nodeses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosises
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Health Status Indicators::Severity of Illness Indexes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Anthropometry::Body Weights and Measures::Tumor Burdenes
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasmses
dc.titleBreast cancer prognostic classification in the molecular era: the role of histological grade.es
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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