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Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models

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dc.contributor.authorGerussi, Alessio
dc.contributor.authorNatalini, Ambra
dc.contributor.authorAntonangeli, Fabrizio
dc.contributor.authorMancuso, Clara
dc.contributor.authorAgostinetto, Elisa
dc.contributor.authorBarisani, Donatella
dc.contributor.authorDi Rosa, Francesca
dc.contributor.authorAndrade, Raul
dc.contributor.authorInvernizzi, Pietro
dc.contributor.authoraffiliation[Gerussi,A; Mancuso,C; Barisani,D; Invernizzi,P] Centre for Autoimmune Liver Diseases, Division of Gastroenterology, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. [Gerussi,A; Mancuso,C; Barisani,D; Invernizzi,P] European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy. [Natalini,A; Antonangeli,F; Di Rosa,F] Institute of Molecular Biology and Pathology (IBPM), National Research Council of Italy (CNR), Rome, Italy. [Agostinetto,E] Academic Trials Promoting Team, Institut Jules Bordet, L’Universite’ Libre de Bruxelles (ULB), Brussels, Belgium. [Agostinetto,E] Medical Oncology and Hematology Unit, Humanitas Clinical and Research Center—IRCCS, Humanitas Cancer Center, Rozzano, Milan, Italy. [Agostinetto,E] Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy. [Andrade,R] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), UGC Aparato Digestivo, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain.
dc.contributor.funderWe acknowledge that this research was partially supported by the Italian Ministry of University and Research (MIUR)—Department of Excellence project PREMIA (PREcision MedIcine Approach: bringing biomarker research to clinic). Research in FD’s lab was funded by MIUR project: 2017K55HLC_006.
dc.date.accessioned2022-05-09T08:31:57Z
dc.date.available2022-05-09T08:31:57Z
dc.date.issued2021-04-27
dc.description.abstractDrug-induced liver injury (DILI) is a challenging clinical event in medicine, particularly because of its ability to present with a variety of phenotypes including that of autoimmune hepatitis or other immune mediated liver injuries. Limited diagnostic and therapeutic tools are available, mostly because its pathogenesis has remained poorly understood for decades. The recent scientific and technological advancements in genomics and immunology are paving the way for a better understanding of the molecular aspects of DILI. This review provides an updated overview of the genetic predisposition and immunological mechanisms behind the pathogenesis of DILI and presents the state-of-the-art experimental models to study DILI at the pre-clinical level.es_ES
dc.description.versionYeses_ES
dc.identifier.citationGerussi A, Natalini A, Antonangeli F, Mancuso C, Agostinetto E, Barisani D, et al. Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models. Int J Mol Sci. 2021 Apr 27;22(9):4557es_ES
dc.identifier.doi10.3390/ijms22094557es_ES
dc.identifier.essn1422-0067
dc.identifier.pmcPMC8123708
dc.identifier.pmid33925355es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3615
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoen
dc.page.number21 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/22/9/4557/htmes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsAcceso abiertoes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectInflammationes_ES
dc.subjectAutoimmune hepatitises_ES
dc.subjectAutoimmunityes_ES
dc.subjectGeneticses_ES
dc.subjectDrug-induced liver injuryes_ES
dc.subjectInflammationes_ES
dc.subjectHepatitis autoinmunees_ES
dc.subjectAutoimmunityes_ES
dc.subjectGenéticaes_ES
dc.subjectEnfermedad hepática inducida por sustancias y drogases_ES
dc.subjectInflamaciónes_ES
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Diseasees_ES
dc.subject.meshMedical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Hepatitis::Hepatitis, Chronic::Hepatitis, Autoimmunees_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Immunogeneticses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoreticales_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotypees_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factorses_ES
dc.titleImmune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Modelses_ES
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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