Acute myeloid leukaemia of donor cell origin developing 17 years after allogenic hematopoietic cell transplantation for acute promyelocytic leukaemia.

Jiménez, Pilar; Alvarez, J Carlos; Garrido, Pilar; Lorente, J Antonio; Palacios, Jorge; Ruiz-Cabello, Francisco

Publication:
Acute myeloid leukaemia of donor cell origin developing 17 years after allogenic hematopoietic cell transplantation for acute promyelocytic leukaemia.

dc.contributor.author	Jiménez, Pilar
dc.contributor.author	Alvarez, J Carlos
dc.contributor.author	Garrido, Pilar
dc.contributor.author	Lorente, J Antonio
dc.contributor.author	Palacios, Jorge
dc.contributor.author	Ruiz-Cabello, Francisco
dc.contributor.authoraffiliation	[Jiménez,P; Ruiz-Cabello,F] Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Alvarez,JC; Lorente,JA] Departamento de Medicina Legal, Universidad de Granada, Spain. [Garrido,P; Palacios,J] 3Servicio de Hematología, Hospital Universitario Virgen de las Nieves, Granada, Spain.	es
dc.contributor.funder	The study was partially supported by grants from the Fondo de Investigaciones Sanitarias (08/0528), Red Genómica del Cáncer (RETICRD 06/020) and Servicio Andaluz de Salud (PI-0273-2010).
dc.date.accessioned	2013-11-29T11:09:33Z
dc.date.available	2013-11-29T11:09:33Z
dc.date.issued	2012-12
dc.description	Journal Article;	es
dc.description.abstract	Donor cell leukaemia (DCL) is a rare complication of allogenic hematopoietic cell transplantation (HCT). We report the case of a female patient with acute promyelocytic leukaemia (APL), FAB type M3, who developed acute myeloid leukaemia (AML) type M5 of donor origin 17 years after allogenic bone marrow transplantation (BMT) from her HLA-matched sister. Morphology and immunophenotyping showed differences with the initial leukaemia, and short tandem repeat (STR) analysis confirmed donor-type haematopoiesis. Interphase fluorescence in situ hybridisation (FISH) showed an 11q23 deletion. Given that the latency period between transplant and development of leukaemia was the longest reported to date, we discuss the mechanisms underlying delayed leukaemia onset.	es
dc.description.version	Yes	es
dc.identifier.citation	Jiménez P, Alvarez JC, Garrido P, Lorente JA, Palacios J, Ruiz-Cabello F. Acute myeloid leukaemia of donor cell origin developing 17 years after allogenic hematopoietic cell transplantation for acute promyelocytic leukaemia. Int J Biomed Sci. 2012; 8(4):244-8	es
dc.identifier.essn	1555-2810
dc.identifier.issn	1550-9702
dc.identifier.pmc	PMC3615294
dc.identifier.pmid	23675279
dc.identifier.uri	http://hdl.handle.net/10668/1402
dc.journal.title	International journal of biomedical science : IJBS
dc.language.iso	en
dc.publisher	Master Publishing Group	es
dc.relation.publisherversion	http://www.ijbs.org/User/ContentAbstractPage.aspx?VolumeNO=8&StartPage=244&EndPage=248&Number=4	es
dc.rights.accessRights	open access
dc.subject	bone marrow transplantation	es
dc.subject	donor cell leukaemia	es
dc.subject	FISH	es
dc.subject	MLL	es
dc.subject	STR	es
dc.subject	Enfermedad Aguda	es
dc.subject	Trasplante de Médula Ósea	es
dc.subject	Leucemia promielocítica aguda	es
dc.subject	Donantes de Tejidos	es
dc.subject	Femenino	es
dc.subject	Trasplante de Células Madre Hematopoyéticas	es
dc.subject	Trasplante Homólogo	es
dc.subject.mesh	Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Acute Disease	es
dc.subject.mesh	Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Tissue Transplantation::Bone Marrow Transplantation	es
dc.subject.mesh	Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Myeloid::Leukemia, Myeloid, Acute::Leukemia, Promyelocytic, Acute	es
dc.subject.mesh	Medical Subject Headings::Named Groups::Persons::Tissue Donors	es
dc.subject.mesh	Medical Subject Headings::Check Tags::Female	es
dc.subject.mesh	Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation	es
dc.subject.mesh	Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Transplantation, Homologous	es
dc.title	Acute myeloid leukaemia of donor cell origin developing 17 years after allogenic hematopoietic cell transplantation for acute promyelocytic leukaemia.	es
dc.type	research article
dc.type.hasVersion	VoR
dspace.entity.type	Publication

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Acute myeloid leukaemia of donor cell origin developing 17 years after allogenic hematopoietic cell transplantation for acute promyelocytic leukaemia.