Publication:
Involvement of the Substance P/Neurokinin-1 Receptor System in Cancer.

dc.contributor.authorCoveñas, Rafael
dc.contributor.authorMuñoz, Miguel
dc.date.accessioned2023-05-03T13:51:25Z
dc.date.available2023-05-03T13:51:25Z
dc.date.issued2022-07-21
dc.description.abstractNew, promising molecular targets to block tumor development and new compounds capable of specifically destroying cancer cells must be urgently investigated. In recent years, the knowledge on the involvement of the substance P (SP)/ neurokinin-1 receptor (NK-1R) system in cancer has attracted increasing interest [1–5]. This has opened up new research lines and possibilities to improve cancer diagnosis and to explore new therapeutic strategies targeting tumor -specific molecular derangements since SP/NK-1R expression has been associated with cancer development and poor prognosis [1–5]. SP, an undecapeptide that binds preferentially to NK-1R, plays crucial roles in cancer development [1–6]: (1) it promotes the mitogenesis/migration of tumor cells ; (2) it exerts antiapoptotic action; (3) it increases the glycolytic rate (Warburg effect); (4) it stimulates the growth of blood vessels, and (5) tumor cells also synthesize and release SP, which acts through autocrine, paracrine, and neuroendocrine ( tumor mass) mechanisms.
dc.description.versionSi
dc.identifier.citationCoveñas R, Muñoz M. Involvement of the Substance P/Neurokinin-1 Receptor System in Cancer. Cancers (Basel). 2022 Jul 21;14(14):3539.
dc.identifier.doi10.3390/cancers14143539
dc.identifier.issn2072-6694
dc.identifier.pmcPMC9317685
dc.identifier.pmid35884599
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317685/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2072-6694/14/14/3539/pdf?version=1658376056
dc.identifier.urihttp://hdl.handle.net/10668/20909
dc.issue.number14
dc.journal.titleCancers
dc.journal.titleabbreviationCancers (Basel)
dc.language.isoen
dc.organizationHospital Universitario Virgen del Rocío
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.page.number5
dc.provenanceRealizada la curación de contenido 05/06/2025.
dc.publisherMDPI AG
dc.pubmedtypeEditorial
dc.relation.publisherversionhttps://www.mdpi.com/resolver?pii=cancers14143539
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectReceptors, Neurokinin-1
dc.subjectNeuroendocrine Tumors
dc.subjectApudoma
dc.subject.decsNeoplasias
dc.subject.decsReceptores de neuroquinina-1
dc.subject.decsInvestigación
dc.subject.decsDiagnóstico
dc.subject.decsSustancia P
dc.subject.decsPronóstico
dc.subject.meshPrognosis
dc.subject.meshCell Proliferation
dc.subject.meshSubstance P
dc.titleInvolvement of the Substance P/Neurokinin-1 Receptor System in Cancer.
dc.typeEditorial
dc.type.hasVersionVoR
dc.volume.number14
dspace.entity.typePublication

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