Publication: Analysis of spontaneous resolution of cytomegalovirus replication after transplantation in CMV-seropositive patients with pretransplant CD8+IFNG+ response.
dc.contributor.author | Paez-Vega, Aurora | |
dc.contributor.author | Poyato, Antonio | |
dc.contributor.author | Rodriguez-Benot, Alberto | |
dc.contributor.author | Guirado, Lluis | |
dc.contributor.author | Fortun, Jesus | |
dc.contributor.author | Len, Oscar | |
dc.contributor.author | Abdala, Edson | |
dc.contributor.author | Fariñas, Maria C | |
dc.contributor.author | Cordero, Elisa | |
dc.contributor.author | de-Gracia, Carmen | |
dc.contributor.author | Hernandez, Domingo | |
dc.contributor.author | Gonzalez, Rafael | |
dc.contributor.author | Torre-Cisneros, Julian | |
dc.contributor.author | Cantisan, Sara | |
dc.contributor.funder | Instituto de Salud Carlos II | |
dc.contributor.funder | Subdirección General de Redes y Centros de Investigación Cooperativa | |
dc.contributor.funder | Ministerio de Economía y Competitividad | |
dc.contributor.funder | Spanish Network for Research in Infectious Diseases | |
dc.contributor.funder | European Development Regional Fund “A way to achieve Europe” | |
dc.contributor.funder | Consejería de Salud, Junta de Andalucía | |
dc.contributor.group | Spanish Renal Disease Network | |
dc.contributor.group | Network for Research in Infectious Diseases | |
dc.date.accessioned | 2023-01-25T10:09:25Z | |
dc.date.available | 2023-01-25T10:09:25Z | |
dc.date.issued | 2018-05-11 | |
dc.description.abstract | This prospective study evaluates whether CMV-seropositive (R+) transplant patients with pretransplant CD8+IFNG+ T-cell response to cytomegalovirus (CMV) (CD8+IFNG+ response) can spontaneously clear the CMV viral load without requiring treatment. A total of 104 transplant patients (kidney/liver) with pretransplant CD8+IFNG+ response were evaluable. This response was determined using QuantiFERON-CMV assay. The incidence of CMV replication and disease was 45.2% (47/104) and 6.7% (7/104), respectively. Of the total patients, 77.9% (81/104) did not require antiviral treatment, either because they did not have CMV replication (n = 57) or because they had asymptomatic CMV replication that could be spontaneously cleared (n = 24). Both situations are likely related to the presence of CD8+IFNG+ response to CMV, which has a key role in controlling CMV infection. However, 22.1% of the patients (23/104) received antiviral treatment, although only 7 of them did so because they had symptomatic CMV replication. These patients developed symptoms in spite of having pretransplant CD8+IFNG+ response, thus suggesting that other immunological parameters might be involved, such as a dysfunctional CD4+ response or that they might have become QFNon-reactive due to the immunosuppression. In conclusion, around 80% of R+ patients with pretransplant CD8+IFNG+ response to CMV did not require antiviral treatment, although this percentage might be underestimated. Nevertheless, other strategies such as performing an additional CD8+IFNG+ response determination at posttransplant time might provide more reliable information regarding the patients who will be able to spontaneously clear the viremia. | |
dc.description.sponsorship | We are grateful to the patients who volunteered to provide blood specimens and we thank the staff at the liver and kidney transplant units from the centers for obtaining the samples. We particularly thank Ana Salinas for invaluable technical support. We also acknowledge the statistical expertise of Llenalia García. This work was supported by Planes Nacionales de I+D+i 2008-2011/2013-2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI RD12/0015/0002 and REIPI RD16/0016/0008, D16/0016/0003, RD16/0016/0011, RD16/0016/0007), Spanish Renal Research Network (REDinREN, RD16/0009/0006, RD16/0009/0034 and RD16/0009/0019), co-financed by European Development Regional Fund “A way to achieve Europe” and operative program Intelligent Growth 2014-2020. It was also supported by the Consejería de Salud, Junta de Andalucía [grant number PI-0004-2012 to S.C.]. Other researchers participating in the study: Pilar Barrera, Marisa Agüera, Cristian Rodelo-Haad, Antonio Rivero-Juárez, Mario Frías | |
dc.description.version | Si | |
dc.identifier.citation | Páez-Vega A, Poyato A, Rodriguez-Benot A, Guirado L, Fortún J, Len O, et al. Analysis of spontaneous resolution of cytomegalovirus replication after transplantation in CMV-seropositive patients with pretransplant CD8+IFNG+ response. Antiviral Res. 2018 Jul;155:97-105 | |
dc.identifier.doi | 10.1016/j.antiviral.2018.05.006 | |
dc.identifier.essn | 1872-9096 | |
dc.identifier.pmid | 29782877 | |
dc.identifier.unpaywallURL | https://repositorio.unican.es/xmlui/bitstream/10902/13756/3/AnalysisSpontaneousResolution.pdf | |
dc.identifier.uri | http://hdl.handle.net/10668/12491 | |
dc.journal.title | Antiviral research | |
dc.journal.titleabbreviation | Antiviral Res | |
dc.language.iso | en | |
dc.organization | Instituto Maimónides de Investigación Biomédica de Córdoba-IMIBIC | |
dc.organization | Hospital Universitario Reina Sofía | |
dc.organization | Hospital Universitario Virgen de las Nieves | |
dc.organization | Hospital Universitario Regional de Málaga | |
dc.organization | Instituto de Investigación Biomédica de Málaga-IBIMA | |
dc.organization | Instituto de Biomedicina de Sevilla-IBIS | |
dc.organization | Hospital Universitario Virgen del Rocío | |
dc.page.number | 97-105 | |
dc.provenance | Realizada la curación de contenido 19/02/2025 | |
dc.publisher | Elsevier | |
dc.pubmedtype | Journal Article | |
dc.pubmedtype | Research Support, Non-U.S. Gov't | |
dc.relation.projectID | REIPI RD12/0015/0002 | |
dc.relation.projectID | RD16/00160008 | |
dc.relation.projectID | RD16/0016/0003 | |
dc.relation.projectID | RD16/0016/0011 | |
dc.relation.projectID | RD16/0016/0007 | |
dc.relation.projectID | RD16/0009/0006 | |
dc.relation.projectID | RD16/0009/0034 | |
dc.relation.projectID | RD16/0009/0019 | |
dc.relation.projectID | PI-0004-2012 | |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0166354218301037?via%3Dihub | |
dc.rights.accessRights | Restricted Access | |
dc.subject | Cytomegalovirus infection | |
dc.subject | Interferon-gamma | |
dc.subject | QuantiFERON-CMV assay | |
dc.subject | Solid organ transplantation | |
dc.subject | T-cell response | |
dc.subject.decs | Carga viral | |
dc.subject.decs | Citomegalovirus | |
dc.subject.decs | Infecciones por citomegalovirus | |
dc.subject.decs | Interferón gamma | |
dc.subject.decs | Linfocitos T CD8-positivos | |
dc.subject.decs | Replicación viral | |
dc.subject.decs | Resistencia a la enfermedad | |
dc.subject.decs | Serología | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Aged | |
dc.subject.mesh | CD8-positive T-lymphocytes | |
dc.subject.mesh | Cytomegalovirus | |
dc.subject.mesh | Cytomegalovirus infections | |
dc.subject.mesh | Disease resistance | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Immunosuppression therapy | |
dc.subject.mesh | Interferon-gamma | |
dc.subject.mesh | Kidney transplantation | |
dc.subject.mesh | Liver transplantation | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle aged | |
dc.subject.mesh | Prospective studies | |
dc.subject.mesh | Serology | |
dc.subject.mesh | Viral load | |
dc.subject.mesh | Viremia | |
dc.subject.mesh | Virus replication | |
dc.title | Analysis of spontaneous resolution of cytomegalovirus replication after transplantation in CMV-seropositive patients with pretransplant CD8+IFNG+ response. | |
dc.type | research article | |
dc.type.hasVersion | AM | |
dc.volume.number | 155 | |
dspace.entity.type | Publication |
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