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Analysis of spontaneous resolution of cytomegalovirus replication after transplantation in CMV-seropositive patients with pretransplant CD8+IFNG+ response.

dc.contributor.authorPaez-Vega, Aurora
dc.contributor.authorPoyato, Antonio
dc.contributor.authorRodriguez-Benot, Alberto
dc.contributor.authorGuirado, Lluis
dc.contributor.authorFortun, Jesus
dc.contributor.authorLen, Oscar
dc.contributor.authorAbdala, Edson
dc.contributor.authorFariñas, Maria C
dc.contributor.authorCordero, Elisa
dc.contributor.authorde-Gracia, Carmen
dc.contributor.authorHernandez, Domingo
dc.contributor.authorGonzalez, Rafael
dc.contributor.authorTorre-Cisneros, Julian
dc.contributor.authorCantisan, Sara
dc.contributor.funderInstituto de Salud Carlos II
dc.contributor.funderSubdirección General de Redes y Centros de Investigación Cooperativa
dc.contributor.funderMinisterio de Economía y Competitividad
dc.contributor.funderSpanish Network for Research in Infectious Diseases
dc.contributor.funderEuropean Development Regional Fund “A way to achieve Europe”
dc.contributor.funderConsejería de Salud, Junta de Andalucía
dc.contributor.groupSpanish Renal Disease Network
dc.contributor.groupNetwork for Research in Infectious Diseases
dc.date.accessioned2023-01-25T10:09:25Z
dc.date.available2023-01-25T10:09:25Z
dc.date.issued2018-05-11
dc.description.abstractThis prospective study evaluates whether CMV-seropositive (R+) transplant patients with pretransplant CD8+IFNG+ T-cell response to cytomegalovirus (CMV) (CD8+IFNG+ response) can spontaneously clear the CMV viral load without requiring treatment. A total of 104 transplant patients (kidney/liver) with pretransplant CD8+IFNG+ response were evaluable. This response was determined using QuantiFERON-CMV assay. The incidence of CMV replication and disease was 45.2% (47/104) and 6.7% (7/104), respectively. Of the total patients, 77.9% (81/104) did not require antiviral treatment, either because they did not have CMV replication (n = 57) or because they had asymptomatic CMV replication that could be spontaneously cleared (n = 24). Both situations are likely related to the presence of CD8+IFNG+ response to CMV, which has a key role in controlling CMV infection. However, 22.1% of the patients (23/104) received antiviral treatment, although only 7 of them did so because they had symptomatic CMV replication. These patients developed symptoms in spite of having pretransplant CD8+IFNG+ response, thus suggesting that other immunological parameters might be involved, such as a dysfunctional CD4+ response or that they might have become QFNon-reactive due to the immunosuppression. In conclusion, around 80% of R+ patients with pretransplant CD8+IFNG+ response to CMV did not require antiviral treatment, although this percentage might be underestimated. Nevertheless, other strategies such as performing an additional CD8+IFNG+ response determination at posttransplant time might provide more reliable information regarding the patients who will be able to spontaneously clear the viremia.
dc.description.sponsorshipWe are grateful to the patients who volunteered to provide blood specimens and we thank the staff at the liver and kidney transplant units from the centers for obtaining the samples. We particularly thank Ana Salinas for invaluable technical support. We also acknowledge the statistical expertise of Llenalia García. This work was supported by Planes Nacionales de I+D+i 2008-2011/2013-2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI RD12/0015/0002 and REIPI RD16/0016/0008, D16/0016/0003, RD16/0016/0011, RD16/0016/0007), Spanish Renal Research Network (REDinREN, RD16/0009/0006, RD16/0009/0034 and RD16/0009/0019), co-financed by European Development Regional Fund “A way to achieve Europe” and operative program Intelligent Growth 2014-2020. It was also supported by the Consejería de Salud, Junta de Andalucía [grant number PI-0004-2012 to S.C.]. Other researchers participating in the study: Pilar Barrera, Marisa Agüera, Cristian Rodelo-Haad, Antonio Rivero-Juárez, Mario Frías
dc.description.versionSi
dc.identifier.citationPáez-Vega A, Poyato A, Rodriguez-Benot A, Guirado L, Fortún J, Len O, et al. Analysis of spontaneous resolution of cytomegalovirus replication after transplantation in CMV-seropositive patients with pretransplant CD8+IFNG+ response. Antiviral Res. 2018 Jul;155:97-105
dc.identifier.doi10.1016/j.antiviral.2018.05.006
dc.identifier.essn1872-9096
dc.identifier.pmid29782877
dc.identifier.unpaywallURLhttps://repositorio.unican.es/xmlui/bitstream/10902/13756/3/AnalysisSpontaneousResolution.pdf
dc.identifier.urihttp://hdl.handle.net/10668/12491
dc.journal.titleAntiviral research
dc.journal.titleabbreviationAntiviral Res
dc.language.isoen
dc.organizationInstituto Maimónides de Investigación Biomédica de Córdoba-IMIBIC
dc.organizationHospital Universitario Reina Sofía
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationHospital Universitario Regional de Málaga
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen del Rocío
dc.page.number97-105
dc.provenanceRealizada la curación de contenido 19/02/2025
dc.publisherElsevier
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.projectIDREIPI RD12/0015/0002
dc.relation.projectIDRD16/00160008
dc.relation.projectIDRD16/0016/0003
dc.relation.projectIDRD16/0016/0011
dc.relation.projectIDRD16/0016/0007
dc.relation.projectIDRD16/0009/0006
dc.relation.projectIDRD16/0009/0034
dc.relation.projectIDRD16/0009/0019
dc.relation.projectIDPI-0004-2012
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0166354218301037?via%3Dihub
dc.rights.accessRightsRestricted Access
dc.subjectCytomegalovirus infection
dc.subjectInterferon-gamma
dc.subjectQuantiFERON-CMV assay
dc.subjectSolid organ transplantation
dc.subjectT-cell response
dc.subject.decsCarga viral
dc.subject.decsCitomegalovirus
dc.subject.decsInfecciones por citomegalovirus
dc.subject.decsInterferón gamma
dc.subject.decsLinfocitos T CD8-positivos
dc.subject.decsReplicación viral
dc.subject.decsResistencia a la enfermedad
dc.subject.decsSerología
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCD8-positive T-lymphocytes
dc.subject.meshCytomegalovirus
dc.subject.meshCytomegalovirus infections
dc.subject.meshDisease resistance
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunosuppression therapy
dc.subject.meshInterferon-gamma
dc.subject.meshKidney transplantation
dc.subject.meshLiver transplantation
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshProspective studies
dc.subject.meshSerology
dc.subject.meshViral load
dc.subject.meshViremia
dc.subject.meshVirus replication
dc.titleAnalysis of spontaneous resolution of cytomegalovirus replication after transplantation in CMV-seropositive patients with pretransplant CD8+IFNG+ response.
dc.typeresearch article
dc.type.hasVersionAM
dc.volume.number155
dspace.entity.typePublication

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