Publication: Multidrug resistance transporter profile reveals MDR3 as a marker for stratification of blastemal Wilms tumour patients.
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Identifiers
Date
2017
Authors
Hontecillas-Prieto, Lourdes
Garcia-Dominguez, Daniel J
Vaca, Diego Pascual
Garcia-Mejias, Rosa
Marcilla, David
Ramirez-Villar, Gema L
Saez, Carmen
de Álava, Enrique
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Wilms tumour (WT) is the most common renal tumour in children. Most WT patients respond to chemotherapy, but subsets of tumours develop resistance to chemotherapeutic agents, which is a major obstacle in their successful treatment. Multidrug resistance transporters play a crucial role in the development of resistance in cancer due to the efflux of anticancer agents out of cells. The aim of this study was to explore several human multidrug resistance transporters in 46 WT and 40 non-neoplastic control tissues (normal kidney) from patients selected after chemotherapy treatment SIOP 93-01, SIOP 2001. Our data showed that the majority of the studied multidrug resistance transporters were downregulated or unchanged between tumours and control tissues. However, BCRP1, MDR3 and MRP1 were upregulated in tumours versus control tissues. MDR3 and MRP1 overexpression correlated with high-risk tumours (SIOP classification) (p = 0.0022 and p
Description
MeSH Terms
ATP Binding Cassette Transporter, Subfamily B
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Child
Child, Preschool
Dactinomycin
Drug Resistance, Multiple
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Immunoblotting
Immunohistochemistry
Infant
Kidney Neoplasms
Membrane Transport Proteins
Multidrug Resistance-Associated Proteins
Nephrectomy
Outcome Assessment, Health Care
Prognosis
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Tissue Array Analysis
Vincristine
Wilms Tumor
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Child
Child, Preschool
Dactinomycin
Drug Resistance, Multiple
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Immunoblotting
Immunohistochemistry
Infant
Kidney Neoplasms
Membrane Transport Proteins
Multidrug Resistance-Associated Proteins
Nephrectomy
Outcome Assessment, Health Care
Prognosis
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Tissue Array Analysis
Vincristine
Wilms Tumor
DeCS Terms
CIE Terms
Keywords
MDR3, MRP1, Wilms tumours, blastemal stratification, multidrug resistance transporters