Publication:
Multidrug resistance transporter profile reveals MDR3 as a marker for stratification of blastemal Wilms tumour patients.

Loading...
Thumbnail Image

Date

2017

Authors

Hontecillas-Prieto, Lourdes
Garcia-Dominguez, Daniel J
Vaca, Diego Pascual
Garcia-Mejias, Rosa
Marcilla, David
Ramirez-Villar, Gema L
Saez, Carmen
de Álava, Enrique

Advisors

Journal Title

Journal ISSN

Volume Title

Publisher

Metrics
Google Scholar
Export

Research Projects

Organizational Units

Journal Issue

Abstract

Wilms tumour (WT) is the most common renal tumour in children. Most WT patients respond to chemotherapy, but subsets of tumours develop resistance to chemotherapeutic agents, which is a major obstacle in their successful treatment. Multidrug resistance transporters play a crucial role in the development of resistance in cancer due to the efflux of anticancer agents out of cells. The aim of this study was to explore several human multidrug resistance transporters in 46 WT and 40 non-neoplastic control tissues (normal kidney) from patients selected after chemotherapy treatment SIOP 93-01, SIOP 2001. Our data showed that the majority of the studied multidrug resistance transporters were downregulated or unchanged between tumours and control tissues. However, BCRP1, MDR3 and MRP1 were upregulated in tumours versus control tissues. MDR3 and MRP1 overexpression correlated with high-risk tumours (SIOP classification) (p = 0.0022 and p

Description

MeSH Terms

ATP Binding Cassette Transporter, Subfamily B
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Child
Child, Preschool
Dactinomycin
Drug Resistance, Multiple
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Immunoblotting
Immunohistochemistry
Infant
Kidney Neoplasms
Membrane Transport Proteins
Multidrug Resistance-Associated Proteins
Nephrectomy
Outcome Assessment, Health Care
Prognosis
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Tissue Array Analysis
Vincristine
Wilms Tumor

DeCS Terms

CIE Terms

Keywords

MDR3, MRP1, Wilms tumours, blastemal stratification, multidrug resistance transporters

Citation