Publication:
The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990-2019: Findings from the Global Burden of Disease Study 2019.

dc.contributor.authorCastelpietra, Giulio
dc.contributor.authorKnudsen, Ann Kristin Skrindo
dc.contributor.authorAgardh, Emilie E
dc.contributor.authorArmocida, Benedetta
dc.contributor.authorBeghi, Massimiliano
dc.contributor.authorIburg, Kim Moesgaard
dc.contributor.authorLogroscino, Giancarlo
dc.contributor.authorMa, Rui
dc.contributor.authorStarace, Fabrizio
dc.contributor.authorSteel, Nicholas
dc.contributor.authorAddolorato, Giovanni
dc.contributor.authorAndrei, Catalina Liliana
dc.contributor.authorAndrei, Tudorel
dc.contributor.authorAyuso-Mateos, Jose L
dc.contributor.authorBanach, Maciej
dc.contributor.authorBärnighausen, Till Winfried
dc.contributor.authorBarone-Adesi, Francesco
dc.contributor.authorBhagavathula, Akshaya Srikanth
dc.contributor.authorCarvalho, Felix
dc.contributor.authorCarvalho, Márcia
dc.contributor.authorChandan, Joht Singh
dc.contributor.authorChattu, Vijay Kumar
dc.contributor.authorCouto, Rosa A S
dc.contributor.authorCruz-Martins, Natália
dc.contributor.authorDargan, Paul I
dc.contributor.authorDeuba, Keshab
dc.contributor.authorda Silva, Diana Dias
dc.contributor.authorFagbamigbe, Adeniyi Francis
dc.contributor.authorFernandes, Eduarda
dc.contributor.authorFerrara, Pietro
dc.contributor.authorFischer, Florian
dc.contributor.authorGaal, Peter Andras
dc.contributor.authorGialluisi, Alessandro
dc.contributor.authorHaagsma, Juanita A
dc.contributor.authorHaro, Josep Maria
dc.contributor.authorHasan, M Tasdik
dc.contributor.authorHasan, Syed Shahzad
dc.contributor.authorHostiuc, Sorin
dc.contributor.authorIacoviello, Licia
dc.contributor.authorIavicoli, Ivo
dc.contributor.authorJamshidi, Elham
dc.contributor.authorJonas, Jost B
dc.contributor.authorJoo, Tamas
dc.contributor.authorJozwiak, Jacek Jerzy
dc.contributor.authorKatikireddi, Srinivasa Vittal
dc.contributor.authorKauppila, Joonas H
dc.contributor.authorKhan, Moien A B
dc.contributor.authorKisa, Adnan
dc.contributor.authorKisa, Sezer
dc.contributor.authorKivimäki, Mika
dc.contributor.authorKoly, Kamrun Nahar
dc.contributor.authorKoyanagi, Ai
dc.contributor.authorKumar, Manasi
dc.contributor.authorLallukka, Tea
dc.contributor.authorLangguth, Berthold
dc.contributor.authorLedda, Caterina
dc.contributor.authorLee, Paul H
dc.contributor.authorLega, Ilaria
dc.contributor.authorLinehan, Christine
dc.contributor.authorLoureiro, Joana A
dc.contributor.authorMadureira-Carvalho, Áurea M
dc.contributor.authorMartinez-Raga, Jose
dc.contributor.authorMathur, Manu Raj
dc.contributor.authorMcGrath, John J
dc.contributor.authorMechili, Enkeleint A
dc.contributor.authorMentis, Alexios-Fotios A
dc.contributor.authorMestrovic, Tomislav
dc.contributor.authorMiazgowski, Bartosz
dc.contributor.authorMirica, Andreea
dc.contributor.authorMirijello, Antonio
dc.contributor.authorMoazen, Babak
dc.contributor.authorMohammed, Shafiu
dc.contributor.authorMulita, Francesk
dc.contributor.authorNagel, Gabriele
dc.contributor.authorNegoi, Ionut
dc.contributor.authorNegoi, Ruxandra Irina
dc.contributor.authorNwatah, Vincent Ebuka
dc.contributor.authorPadron-Monedero, Alicia
dc.contributor.authorPanda-Jonas, Songhomitra
dc.contributor.authorPardhan, Shahina
dc.contributor.authorPasovic, Maja
dc.contributor.authorPatel, Jay
dc.contributor.authorPetcu, Ionela-Roxana
dc.contributor.authorPinheiro, Marina
dc.contributor.authorPollok, Richard Charles G
dc.contributor.authorPostma, Maarten J
dc.contributor.authorRawaf, David Laith
dc.contributor.authorRawaf, Salman
dc.contributor.authorRomero-Rodríguez, Esperanza
dc.contributor.authorRonfani, Luca
dc.contributor.authorSagoe, Dominic
dc.contributor.authorSanmarchi, Francesco
dc.contributor.authorSchaub, Michael P
dc.contributor.authorSharew, Nigussie Tadesse
dc.contributor.authorShiri, Rahman
dc.contributor.authorShokraneh, Farhad
dc.contributor.authorSigfusdottir, Inga Dora
dc.contributor.authorSilva, João Pedro
dc.contributor.authorSilva, Renata
dc.contributor.authorSocea, Bogdan
dc.contributor.authorSzócska, Miklós
dc.contributor.authorTabarés-Seisdedos, Rafael
dc.contributor.authorTorrado, Marco
dc.contributor.authorTovani-Palone, Marcos Roberto
dc.contributor.authorVasankari, Tommi Juhani
dc.contributor.authorVeroux, Massimiliano
dc.contributor.authorViner, Russell M
dc.contributor.authorWerdecker, Andrea
dc.contributor.authorWinkler, Andrea Sylvia
dc.contributor.authorHay, Simon I
dc.contributor.authorFerrari, Alize J
dc.contributor.authorNaghavi, Mohsen
dc.contributor.authorAllebeck, Peter
dc.contributor.authorMonasta, Lorenzo
dc.date.accessioned2023-05-03T15:07:09Z
dc.date.available2023-05-03T15:07:09Z
dc.date.issued2022
dc.description.abstractMental health is a public health issue for European young people, with great heterogeneity in resource allocation. Representative population-based studies are needed. The Global Burden of Disease (GBD) Study 2019 provides internationally comparable information on trends in the health status of populations and changes in the leading causes of disease burden over time. Prevalence, incidence, Years Lived with Disability (YLDs) and Years of Life Lost (YLLs) from mental disorders (MDs), substance use disorders (SUDs) and self-harm were estimated for young people aged 10-24 years in 31 European countries. Rates per 100,000 population, percentage changes in 1990-2019, 95% Uncertainty Intervals (UIs), and correlations with Sociodemographic Index (SDI), were estimated. In 2019, rates per 100,000 population were 16,983 (95% UI 12,823 - 21,630) for MDs, 3,891 (3,020 - 4,905) for SUDs, and 89·1 (63·8 - 123·1) for self-harm. In terms of disability, anxiety contributed to 647·3 (432-912·3) YLDs, while in terms of premature death, self-harm contributed to 319·6 (248·9-412·8) YLLs, per 100,000 population. Over the 30 years studied, YLDs increased in eating disorders (14·9%;9·4-20·1) and drug use disorders (16·9%;8·9-26·3), and decreased in idiopathic developmental intellectual disability (-29·1%;23·8-38·5). YLLs decreased in self-harm (-27·9%;38·3-18·7). Variations were found by sex, age-group and country. The burden of SUDs and self-harm was higher in countries with lower SDI, MDs were associated with SUDs. Mental health conditions represent an important burden among young people living in Europe. National policies should strengthen mental health, with a specific focus on young people. The Bill and Melinda Gates Foundation.
dc.description.sponsorshipTWB€arnighausen was supported by the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award, funded by the German Federal Ministry of Education and Research. F Carvalho acknowledges support from Fundacao para a Ciencia ea Tecnologia (FCT), I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences - UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy - i4HB; FCT/MCTES (Ministerio da Ci^encia, Tecnologia e Ensino Superior) through the project UIDB/50006/2020. M Carvalho acknowledges the support from FCT in the scope of the project IDP/04378/2020 and UIDB/04378/2020 of UCIBIO and the project LA/P/ 0140/2020 of i4HB. J S Chandan is funded on a lectureship post by the National Institute of Health Research (NIHR) and has been awarded funds from the NIHR and the Youth Endowment Fund. S Dias da Silva acknowledges the projects UIDP/04378/2021 and UIDB/04378/2021 of the Research Unit on Applied Molecular Biosciences−UCIBIO; the project LA/P/ 0140/2021 of the Associate Laboratory Institute for Health and Bioeconomy−i4HB; and TOXRUN − Toxicology Research Unit, University Institute of Health Sciences, IUCS-CESPU, Portugal. A J Ferrari is supported by a National Health and Medical Research Council Early Career Fellowship Grant APP1121516 and is employed by the Queensland Centre for Mental Health Research which receives core funding from the Queensland Department of Health. S V Katikireddi would like to acknowledge funding from a NRS Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_00022/2) and the Scottish Government Chief Scientist Office (SPHSU17). J H Kauppila reports research grants from Sigrid Juselius Foundation and the Finnish Cancer Foundation. M Kivimaki was supported by the Wellcome Trust (221854/Z/20/Z) and the Medical Research Council, UK (MR/R024227/1, MR/S011676/1). M Kumar would like to acknowledge
dc.identifier.citationCastelpietra G, Knudsen AKS, Agardh EE, Armocida B, Beghi M, Iburg KM, et al. The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990-2019: Findings from the Global Burden of Disease Study 2019. Lancet Reg Health Eur. 2022 Apr 1;16:100341
dc.identifier.doi10.1016/j.lanepe.2022.100341
dc.identifier.essn2666-7762
dc.identifier.pmcPMC8980870
dc.identifier.pmid35392452
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8980870/pdf
dc.identifier.unpaywallURLhttps://doi.org/10.1016/j.lanepe.2022.100341
dc.identifier.urihttp://hdl.handle.net/10668/22349
dc.journal.titleThe Lancet regional health. Europe
dc.journal.titleabbreviationLancet Reg Health Eur
dc.language.isoen
dc.organizationInstituto Maimónides de Investigación Biomédica de Córdoba-IMIBIC
dc.page.number18
dc.publisherThe Lancet Publishing Group
dc.pubmedtypeJournal Article
dc.relation.publisherversionhttps://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(22)00034-5/fulltext
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEurope
dc.subjectMental disorders
dc.subjectMental health
dc.subjectSelf-harm
dc.subjectSubstance use
dc.subjectYoung people
dc.subject.meshGlobal burden of disease
dc.subject.meshMortality, premature
dc.subject.meshDisability-adjusted life years
dc.subject.meshIntellectual disability
dc.subject.meshMental health
dc.subject.meshPrevalence
dc.subject.meshPublic health
dc.subject.meshCost of illness
dc.titleThe burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990-2019: Findings from the Global Burden of Disease Study 2019.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number16
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 2 of 2
Loading...
Thumbnail Image
Name:
PMC8980870.pdf
Size:
1.69 MB
Format:
Adobe Portable Document Format
No Thumbnail Available
Name:
Castelpietro_TheBurden_MaterialSuplementario.zip
Size:
2.24 MB
Format: