Publication:
Dr. Jekyll and Mr. Hyde: MAP17's up-regulation, a crosspoint in cancer and inflammatory diseases.

dc.contributor.authorGarcia-Heredia, Jose M
dc.contributor.authorCarnero, Amancio
dc.contributor.funderSpanish Ministry of Economy and Competitivity
dc.contributor.funderCIBER de Cáncer
dc.contributor.funderFEDER from Regional Development European Funds (European Union)
dc.contributor.funderConsejeria de Ciencia e Innovacion
dc.contributor.funderConsejeria de Salud of the Junta de Andalucia
dc.date.accessioned2023-01-25T10:06:34Z
dc.date.available2023-01-25T10:06:34Z
dc.date.issued2018-04-12
dc.description.abstractInflammation is a common defensive response that is activated after different harmful stimuli. This chronic, or pathological, inflammation is also one of the causes of neoplastic transformation and cancer development. MAP17 is a small protein localized to membranes with a restricted pattern of expression in adult tissues . However, its expression is common in destabilized cells , as it is overexpressed both in inflammatory diseases and in cancer . MAP17 is overexpressed in most, if not all, carcinomas and in many tumors of mesenchymal origin, and correlates with higher grade and poorly differentiated tumors . This overexpression drives deep changes in cell homeostasis including increased oxidative stress , deregulation of signaling pathways and increased growth rates. Importantly, MAP17 is associated in tumors with inflammatory cells infiltration, not only in cancer but in various inflammatory diseases such as Barret’s esophagus , lupus, Crohn’s, psoriasis and COPD . Furthermore, MAP17 also modifies the expression of genes connected to inflammation , showing a clear induction of the inflammatory profile. Since MAP17 appears highly correlated with the infiltration of inflammatory cells in cancer , is MAP17 overexpression an important cellular event connecting tumorigenesis and inflammation ?
dc.description.sponsorshipAC lab was supported by grants from the Spanish Ministry of Economy and Competitivity, Plan Estatal de I + D + I 2013-2016, ISCIII (Fis: PI15/00045) and CIBER de Cáncer (CB16/12/00275), co-funded by FEDER from Regional Development European Funds (European Union), Consejeria de Ciencia e Innovacion (CTS-1848) and Consejeria de Salud of the Junta de Andalucia (PI-0096-2014). We especially thank the AECC Foundation for supporting this work.
dc.description.versionSi
dc.identifier.citationGarcía-Heredia JM, Carnero A. Dr. Jekyll and Mr. Hyde: MAP17's up-regulation, a crosspoint in cancer and inflammatory diseases. Mol Cancer. 2018 Apr 12;17(1):80.
dc.identifier.doi10.1186/s12943-018-0828-7
dc.identifier.essn1476-4598
dc.identifier.pmcPMC5896160
dc.identifier.pmid29650022
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896160/pdf
dc.identifier.unpaywallURLhttps://doi.org/10.1186/s12943-018-0828-7
dc.identifier.urihttp://hdl.handle.net/10668/12341
dc.issue.number1
dc.journal.titleMolecular cancer
dc.journal.titleabbreviationMol Cancer
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen del Rocío
dc.page.number16
dc.provenanceRealizada la curación de contenido 25/04/2025
dc.publisherBioMed Central Ltd.
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.pubmedtypeReview
dc.relation.projectIDPI-0096-2014
dc.relation.projectIDCB16/12/00275
dc.relation.projectIDPI15/00045
dc.relation.projectIDCTS-1848
dc.relation.publisherversionhttps://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-018-0828-7
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCancer
dc.subjectInflammatory diseases
dc.subjectMAP17
dc.subject.decsNeoplasias
dc.subject.decsInflamación
dc.subject.decsMembranas
dc.subject.decsEstrés oxidativo
dc.subject.decsCarcinogénesis
dc.subject.decsCrecimiento
dc.subject.decsGenes
dc.subject.decsEsófago
dc.subject.decsEnfermedad Pulmonar Obstructiva Crónica
dc.subject.decsHomeostasis
dc.subject.meshGene Expression Regulation, Neoplastic
dc.subject.meshHumans
dc.subject.meshInflammation
dc.subject.meshMembrane Proteins
dc.subject.meshNeoplasms
dc.subject.meshOxidative Stress
dc.subject.meshSignal Transduction
dc.subject.meshUp-Regulation
dc.titleDr. Jekyll and Mr. Hyde: MAP17's up-regulation, a crosspoint in cancer and inflammatory diseases.
dc.typeReview
dc.type.hasVersionVoR
dc.volume.number17
dspace.entity.typePublication

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