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Discovery of common and rare genetic risk variants for colorectal cancer.

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dc.contributor.authorHuyghe, Jeroen R
dc.contributor.authorBien, Stephanie A
dc.contributor.authorHarrison, Tabitha A
dc.contributor.authorKang, Hyun Min
dc.contributor.authorChen, Sai
dc.contributor.authorSchmit, Stephanie L
dc.contributor.authorConti, David V
dc.contributor.authorQu, Conghui
dc.contributor.authorJeon, Jihyoun
dc.contributor.authorEdlund, Christopher K
dc.contributor.authorGreenside, Peyton
dc.contributor.authorWainberg, Michael
dc.contributor.authorSchumacher, Fredrick R
dc.contributor.authorSmith, Joshua D
dc.contributor.authorLevine, David M
dc.contributor.authorNelson, Sarah C
dc.contributor.authorSinnott-Armstrong, Nasa A
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorAlonso, M Henar
dc.contributor.authorAnderson, Kristin
dc.contributor.authorArnau-Collell, Coral
dc.contributor.authorArndt, Volker
dc.contributor.authorBamia, Christina
dc.contributor.authorBanbury, Barbara L
dc.contributor.authorBaron, John A
dc.contributor.authorBerndt, Sonja I
dc.contributor.authorBézieau, Stéphane
dc.contributor.authorBishop, D Timothy
dc.contributor.authorBoehm, Juergen
dc.contributor.authorBoeing, Heiner
dc.contributor.authorBrenner, Hermann
dc.contributor.authorBrezina, Stefanie
dc.contributor.authorBuch, Stephan
dc.contributor.authorBuchanan, Daniel D
dc.contributor.authorBurnett-Hartman, Andrea
dc.contributor.authorButterbach, Katja
dc.contributor.authorCaan, Bette J
dc.contributor.authorCampbell, Peter T
dc.contributor.authorCarlson, Christopher S
dc.contributor.authorCastellví-Bel, Sergi
dc.contributor.authorChan, Andrew T
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorChanock, Stephen J
dc.contributor.authorChirlaque, Maria-Dolores
dc.contributor.authorCho, Sang Hee
dc.contributor.authorConnolly, Charles M
dc.contributor.authorCross, Amanda J
dc.contributor.authorCuk, Katarina
dc.contributor.authorCurtis, Keith R
dc.contributor.authorde la Chapelle, Albert
dc.contributor.authorDoheny, Kimberly F
dc.contributor.authorDuggan, David
dc.contributor.authorEaston, Douglas F
dc.contributor.authorElias, Sjoerd G
dc.contributor.authorElliott, Faye
dc.contributor.authorEnglish, Dallas R
dc.contributor.authorFeskens, Edith J M
dc.contributor.authorFigueiredo, Jane C
dc.contributor.authorFischer, Rocky
dc.contributor.authorFitzGerald, Liesel M
dc.contributor.authorForman, David
dc.contributor.authorGala, Manish
dc.contributor.authorGallinger, Steven
dc.contributor.authorGauderman, W James
dc.contributor.authorGiles, Graham G
dc.contributor.authorGillanders, Elizabeth
dc.contributor.authorGong, Jian
dc.contributor.authorGoodman, Phyllis J
dc.contributor.authorGrady, William M
dc.contributor.authorGrove, John S
dc.contributor.authorGsur, Andrea
dc.contributor.authorGunter, Marc J
dc.contributor.authorHaile, Robert W
dc.contributor.authorHampe, Jochen
dc.contributor.authorHampel, Heather
dc.contributor.authorHarlid, Sophia
dc.contributor.authorHayes, Richard B
dc.contributor.authorHofer, Philipp
dc.contributor.authorHoffmeister, Michael
dc.contributor.authorHopper, John L
dc.contributor.authorHsu, Wan-Ling
dc.contributor.authorHuang, Wen-Yi
dc.contributor.authorHudson, Thomas J
dc.contributor.authorHunter, David J
dc.contributor.authorIbañez-Sanz, Gemma
dc.contributor.authorIdos, Gregory E
dc.contributor.authorIngersoll, Roxann
dc.contributor.authorJackson, Rebecca D
dc.contributor.authorJacobs, Eric J
dc.contributor.authorJenkins, Mark A
dc.contributor.authorJoshi, Amit D
dc.contributor.authorJoshu, Corinne E
dc.contributor.authorKeku, Temitope O
dc.contributor.authorKey, Timothy J
dc.contributor.authorKim, Hyeong Rok
dc.contributor.authorKobayashi, Emiko
dc.contributor.authorKolonel, Laurence N
dc.contributor.authorKooperberg, Charles
dc.contributor.authorKühn, Tilman
dc.contributor.authorKüry, Sébastien
dc.contributor.authorKweon, Sun-Seog
dc.contributor.authorLarsson, Susanna C
dc.contributor.authorLaurie, Cecelia A
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorLeal, Suzanne M
dc.contributor.authorLee, Soo Chin
dc.contributor.authorLejbkowicz, Flavio
dc.contributor.authorLemire, Mathieu
dc.contributor.authorLi, Christopher I
dc.contributor.authorLi, Li
dc.contributor.authorLieb, Wolfgang
dc.contributor.authorLin, Yi
dc.contributor.authorLindblom, Annika
dc.contributor.authorLindor, Noralane M
dc.contributor.authorLing, Hua
dc.contributor.authorLouie, Tin L
dc.contributor.authorMännistö, Satu
dc.contributor.authorMarkowitz, Sanford D
dc.contributor.authorMartín, Vicente
dc.contributor.authorMasala, Giovanna
dc.contributor.authorMcNeil, Caroline E
dc.contributor.authorMelas, Marilena
dc.contributor.authorMilne, Roger L
dc.contributor.authorMoreno, Lorena
dc.contributor.authorMurphy, Neil
dc.contributor.authorMyte, Robin
dc.contributor.authorNaccarati, Alessio
dc.contributor.authorNewcomb, Polly A
dc.contributor.authorOffit, Kenneth
dc.contributor.authorOgino, Shuji
dc.contributor.authorOnland-Moret, N Charlotte
dc.contributor.authorPardini, Barbara
dc.contributor.authorParfrey, Patrick S
dc.contributor.authorPearlman, Rachel
dc.contributor.authorPerduca, Vittorio
dc.contributor.authorPharoah, Paul D P
dc.contributor.authorPinchev, Mila
dc.contributor.authorPlatz, Elizabeth A
dc.contributor.authorPrentice, Ross L
dc.contributor.authorPugh, Elizabeth
dc.contributor.authorRaskin, Leon
dc.contributor.authorRennert, Gad
dc.contributor.authorRennert, Hedy S
dc.contributor.authorRiboli, Elio
dc.contributor.authorRodríguez-Barranco, Miguel
dc.contributor.authorRomm, Jane
dc.contributor.authorSakoda, Lori C
dc.contributor.authorSchafmayer, Clemens
dc.contributor.authorSchoen, Robert E
dc.contributor.authorSeminara, Daniela
dc.contributor.authorShah, Mitul
dc.contributor.authorShelford, Tameka
dc.contributor.authorShin, Min-Ho
dc.contributor.authorShulman, Katerina
dc.contributor.authorSieri, Sabina
dc.contributor.authorSlattery, Martha L
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorStadler, Zsofia K
dc.contributor.authorStegmaier, Christa
dc.contributor.authorSu, Yu-Ru
dc.contributor.authorTangen, Catherine M
dc.contributor.authorThibodeau, Stephen N
dc.contributor.authorThomas, Duncan C
dc.contributor.authorThomas, Sushma S
dc.contributor.authorToland, Amanda E
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorUlrich, Cornelia M
dc.contributor.authorVan Den Berg, David J
dc.contributor.authorvan Duijnhoven, Franzel J B
dc.contributor.authorVan Guelpen, Bethany
dc.contributor.authorvan Kranen, Henk
dc.contributor.authorVijai, Joseph
dc.contributor.authorVisvanathan, Kala
dc.contributor.authorVodicka, Pavel
dc.contributor.authorVodickova, Ludmila
dc.contributor.authorVymetalkova, Veronika
dc.contributor.authorWeigl, Korbinian
dc.contributor.authorWeinstein, Stephanie J
dc.contributor.authorWhite, Emily
dc.contributor.authorWin, Aung Ko
dc.contributor.authorWolf, C Roland
dc.contributor.authorWolk, Alicja
dc.contributor.authorWoods, Michael O
dc.contributor.authorWu, Anna H
dc.contributor.authorZaidi, Syed H
dc.contributor.authorZanke, Brent W
dc.contributor.authorZhang, Qing
dc.contributor.authorZheng, Wei
dc.contributor.authorScacheri, Peter C
dc.contributor.authorPotter, John D
dc.contributor.authorBassik, Michael C
dc.contributor.authorKundaje, Anshul
dc.contributor.authorCasey, Graham
dc.contributor.authorMoreno, Victor
dc.contributor.authorAbecasis, Goncalo R
dc.contributor.authorNickerson, Deborah A
dc.contributor.authorGruber, Stephen B
dc.contributor.authorHsu, Li
dc.contributor.authorPeters, Ulrike
dc.date.accessioned2023-01-25T10:25:44Z
dc.date.available2023-01-25T10:25:44Z
dc.date.issued2018-12-03
dc.description.abstractTo further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P 
dc.identifier.doi10.1038/s41588-018-0286-6
dc.identifier.essn1546-1718
dc.identifier.pmcPMC6358437
dc.identifier.pmid30510241
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358437/pdf
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc6358437?pdf=render
dc.identifier.urihttp://hdl.handle.net/10668/13276
dc.issue.number1
dc.journal.titleNature genetics
dc.journal.titleabbreviationNat Genet
dc.language.isoen
dc.organizationEscuela Andaluza de Salud Pública-EASP
dc.organizationHospital Universitario San Cecilio
dc.page.number76-87
dc.pubmedtypeJournal Article
dc.pubmedtypeMeta-Analysis
dc.rights.accessRightsopen access
dc.subject.meshAged
dc.subject.meshCase-Control Studies
dc.subject.meshColorectal Neoplasms
dc.subject.meshFemale
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshGenome-Wide Association Study
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshRNA, Long Noncoding
dc.subject.meshRisk Factors
dc.subject.meshSignal Transduction
dc.titleDiscovery of common and rare genetic risk variants for colorectal cancer.
dc.typeresearch article
dc.type.hasVersionAM
dc.volume.number51
dspace.entity.typePublication

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