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Telotristat ethyl in carcinoid syndrome: safety and efficacy in the TELECAST phase 3 trial.

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Date

2018-01-12

Authors

Pavel, Marianne
Gross, David J
Benavent, Marta
Perros, Petros
Srirajaskanthan, Raj
Warner, Richard R P
Kulke, Matthew H
Anthony, Lowell B
Kunz, Pamela L
Hörsch, Dieter

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Abstract

Telotristat ethyl, a tryptophan hydroxylase inhibitor, was efficacious and well tolerated in the phase 3 TELESTAR study in patients with carcinoid syndrome (CS) experiencing ≥4 bowel movements per day (BMs/day) while on somatostatin analogs (SSAs). TELECAST, a phase 3 companion study, assessed the safety and efficacy of telotristat ethyl in patients with CS (diarrhea, flushing, abdominal pain, nausea or elevated urinary 5-hydroxyindoleacetic acid (u5-HIAA)) with

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Adult
Aged
Aged, 80 and over
Diarrhea
Double-Blind Method
Female
Humans
Hydroxyindoleacetic Acid
Male
Malignant Carcinoid Syndrome
Middle Aged
Phenylalanine
Pyrimidines
Somatostatin
Treatment Outcome

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Keywords

5-HIAA, carcinoid syndrome, metastatic neuroendocrine tumor, serotonin, somatostatin analog

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