Publication: The American Society of Peritoneal Surface Malignancies Multi-Institution Evaluation of 1,051 Advanced Ovarian Cancer Patients Undergoing Cytoreductive Surgery and HIPEC: An Introduction of the Peritoneal Surface Disease Severity Score
dc.contributor.author | Foster, Jason M | |
dc.contributor.author | Sleightholm, Richard | |
dc.contributor.author | Smith, Lynette | |
dc.contributor.author | Ceelen, Wim | |
dc.contributor.author | Deraco, Marcello | |
dc.contributor.author | Yildirim, Yusuf | |
dc.contributor.author | Levine, Edward | |
dc.contributor.author | Muñoz-Casares, Cristobal | |
dc.contributor.author | Glehen, Olivier | |
dc.contributor.author | Patel, Asish | |
dc.contributor.author | Esquivel, Jesus | |
dc.date.accessioned | 2023-01-25T10:22:55Z | |
dc.date.available | 2023-01-25T10:22:55Z | |
dc.date.issued | 2016-10-28 | |
dc.description.abstract | Background: Standard treatment for ovarian epithelial cancer (OEC) consists of cytoreductive surgery (CRS) and a platinum-taxane chemotherapy combination. There is increasing interest in evaluating hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with stage IIIC/IV disease. The peritoneal surface disease severity score (PSDSS) was introduced as a basis to improve patient selection for this therapy in OEC. Methods: The charts of 1,051 patients with advanced OEC who underwent CRS/HIPEC were retrospectively evaluated using the following preoperatively obtained criteria: symptoms, peritoneal dissemination, and tumor histology. Overall survival was analyzed according to PSDSS as well as the timings and agents used during CRS/HIPEC. Results: Median survival for all 1,051 patients was 73.4 months. PSDSS information was available for 553 patients. Survival correlated negatively with PSDSS (P < 0.001). Furthermore, combining PSDSS scores into I/II and III/IV described two distinct patient populations with vastly different outcomes, 100 versus 55 months, respectively (P < 0.001). Multivariate analysis failed to describe any differences between timings of HIPEC or chemotherapy agents used. Conclusion: PSDSS was capable of identifying a better surviving patient population in advanced-stage OEC. While randomized trials to evaluate the benefit of HIPEC are needed, the PSDSS may be a useful tool for selecting and stratifying OEC patients in clinical trials. | |
dc.description.version | Si | |
dc.identifier.citation | Foster JM, Sleightholm R, Smith L, Ceelen W, Deraco M, Yildirim Y, et al. The American Society of Peritoneal Surface Malignancies Multi-Institution evaluation of 1,051 advanced ovarian cancer patients undergoing cytoreductive surgery and HIPEC: An introduction of the peritoneal surface disease severity score. J Surg Oncol. 2016 Dec;114(7):779-784 | |
dc.identifier.doi | 10.1002/jso.24603 | |
dc.identifier.essn | 1096-9098 | |
dc.identifier.pmid | 30295939 | |
dc.identifier.unpaywallURL | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jso.24603 | |
dc.identifier.uri | http://hdl.handle.net/10668/13041 | |
dc.issue.number | 4 | |
dc.journal.title | Journal of surgical oncology | |
dc.journal.titleabbreviation | J Surg Oncol | |
dc.language.iso | en | |
dc.organization | Hospital Universitario Reina Sofía | |
dc.page.number | 1 | |
dc.provenance | Realizada la curación de contenido 21/07/2025 | |
dc.publisher | John Wiley and Sons | |
dc.pubmedtype | Journal Article | |
dc.relation.publisherversion | https://doi.org/10.1002/jso.24406 | |
dc.rights.accessRights | Restricted Access | |
dc.subject | PSDSS | |
dc.subject | OEC ovarian epithelial cancer | |
dc.subject | CRS | |
dc.subject | HIPEC | |
dc.subject.decs | Quimioterapia intraperitoneal hipertérmica | |
dc.subject.decs | Protocolos de quimioterapia combinada antineoplásica | |
dc.subject.decs | Supervivencia sin enfermedad | |
dc.subject.decs | Terapia neoadyuvante | |
dc.subject.decs | Hepatectomía | |
dc.subject.mesh | Hyperthermic Intraperitoneal Chemotherapy | |
dc.subject.mesh | Carcinoma, Ovarian Epithelial | |
dc.subject.mesh | Cytoreduction Surgical Procedures | |
dc.title | The American Society of Peritoneal Surface Malignancies Multi-Institution Evaluation of 1,051 Advanced Ovarian Cancer Patients Undergoing Cytoreductive Surgery and HIPEC: An Introduction of the Peritoneal Surface Disease Severity Score | |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 118 | |
dspace.entity.type | Publication |
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