Publication:
Omics Approaches in Adipose Tissue and Skeletal Muscle Addressing the Role of Extracellular Matrix in Obesity and Metabolic Dysfunction

dc.contributor.authorAnguita-Ruiz, Augusto
dc.contributor.authorBustos-Aibar, Mireia
dc.contributor.authorPlaza-Díaz, Julio
dc.contributor.authorMendez-Gutierrez, Andrea
dc.contributor.authorAlcalá-Fdez, Jesús
dc.contributor.authorAguilera, Concepción María
dc.contributor.authorRuiz-Ojeda, Francisco Javier
dc.contributor.authoraffiliation[Anguita-Ruiz,A; Bustos-Aibar,M; Plaza-Díaz,J; Mendez-Gutierrez,A; Aguilera,CM; Ruiz-Ojeda,FJ] Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, Spain. [Anguita-Ruiz,A; Plaza-Díaz,J; Mendez-Gutierrez,A; Aguilera,CM; Ruiz-Ojeda,FJ] Instituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, Granada, Spain. [Anguita-Ruiz,A; Bustos-Aibar,M; Plaza-Díaz,J; Mendez-Gutierrez,A; Aguilera,CM] Institute of Nutrition and Food Technology “José Mataix”, Center of Biomedical Research, University of Granada, Granada, Spain. [Anguita-Ruiz,A; Mendez-Gutierrez,A; Aguilera,CM] CIBEROBN (CIBER Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain. [Plaza-Díaz,J] Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada. [Alcalá-Fdez,J] Department of Computer Science and Artificial Intelligence, University of Granada, Granada, Spain. [Ruiz-Ojeda,FJ] RG Adipocytes and Metabolism, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Center Munich, Neuherberg, Munich, Germany.
dc.contributor.funderAMG is supported by a doctorate fellowship Formación del Profesorado Universitario (FPU 16/03653)”, which is being completed as part of the Nutrition and Food Sciences Program at the University of Granada, Spain. AAR is supported by a doctorate contract i-PFIS: Doctorados IIS-empresa en ciencias y tecnologías de la salud (IFI17/00048). JPD is supported by a grant to postdoctoral researchers at foreign Universities and Research Centers from the “Ramón-Areces Foundation”, Spain. FJRO is part of the “Personal Investigador Doctor”, University of Granada, funded by Junta de Andalucía (PAIDI, 2020).
dc.date.accessioned2022-11-29T12:51:59Z
dc.date.available2022-11-29T12:51:59Z
dc.date.issued2021-03-09
dc.description.abstractExtracellular matrix (ECM) remodeling plays important roles in both white adipose tissue (WAT) and the skeletal muscle (SM) metabolism. Excessive adipocyte hypertrophy causes fibrosis, inflammation, and metabolic dysfunction in adipose tissue, as well as impaired adipogenesis. Similarly, disturbed ECM remodeling in SM has metabolic consequences such as decreased insulin sensitivity. Most of described ECM molecular alterations have been associated with DNA sequence variation, alterations in gene expression patterns, and epigenetic modifications. Among others, the most important epigenetic mechanism by which cells are able to modulate their gene expression is DNA methylation. Epigenome-Wide Association Studies (EWAS) have become a powerful approach to identify DNA methylation variation associated with biological traits in humans. Likewise, Genome-Wide Association Studies (GWAS) and gene expression microarrays have allowed the study of whole-genome genetics and transcriptomics patterns in obesity and metabolic diseases. The aim of this review is to explore the molecular basis of ECM in WAT and SM remodeling in obesity and the consequences of metabolic complications. For that purpose, we reviewed scientific literature including all omics approaches reporting genetic, epigenetic, and transcriptomic (GWAS, EWAS, and RNA-seq or cDNA arrays) ECM-related alterations in WAT and SM as associated with metabolic dysfunction and obesity.es_ES
dc.description.versionYeses_ES
dc.identifier.citationAnguita-Ruiz A, Bustos-Aibar M, Plaza-Díaz J, Mendez-Gutierrez A, Alcalá-Fdez J, Aguilera CM, et al. Omics Approaches in Adipose Tissue and Skeletal Muscle Addressing the Role of Extracellular Matrix in Obesity and Metabolic Dysfunction. Int J Mol Sci. 2021 Mar 9;22(5):2756es_ES
dc.identifier.doi10.3390/ijms22052756es_ES
dc.identifier.essn1422-0067
dc.identifier.issn1661-6596
dc.identifier.pmcPMC7963192
dc.identifier.pmid33803198es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4430
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoen
dc.page.number33 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/22/5/2756/htmes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsAcceso abiertoes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectObesityes_ES
dc.subjectAdipose tissuees_ES
dc.subjectExtracellular matrixes_ES
dc.subjectSkeletal musclees_ES
dc.subjectGeneticses_ES
dc.subjectEpigenetices_ES
dc.subjectTranscriptomices_ES
dc.subjectObesidades_ES
dc.subjectTejido adiposoes_ES
dc.subjectMatriz extracelulares_ES
dc.subjectMúsculo esqueléticoes_ES
dc.subjectGenéticaes_ES
dc.subjectEpigenómicaes_ES
dc.subjectTranscriptomaes_ES
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, Whitees_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses_ES
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Cellular Structures::Extracellular Space::Extracellular Matrixes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genetic Association Studies::Genome-Wide Association Studyes_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseaseses_ES
dc.subject.meshMedical Subject Headings::Anatomy::Musculoskeletal System::Muscles::Muscle, Skeletales_ES
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesityes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetices_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Transcription, Genetic::Transcriptomees_ES
dc.titleOmics Approaches in Adipose Tissue and Skeletal Muscle Addressing the Role of Extracellular Matrix in Obesity and Metabolic Dysfunctiones_ES
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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