Publication: Omics Approaches in Adipose Tissue and Skeletal Muscle Addressing the Role of Extracellular Matrix in Obesity and Metabolic Dysfunction
dc.contributor.author | Anguita-Ruiz, Augusto | |
dc.contributor.author | Bustos-Aibar, Mireia | |
dc.contributor.author | Plaza-Díaz, Julio | |
dc.contributor.author | Mendez-Gutierrez, Andrea | |
dc.contributor.author | Alcalá-Fdez, Jesús | |
dc.contributor.author | Aguilera, Concepción María | |
dc.contributor.author | Ruiz-Ojeda, Francisco Javier | |
dc.contributor.authoraffiliation | [Anguita-Ruiz,A; Bustos-Aibar,M; Plaza-Díaz,J; Mendez-Gutierrez,A; Aguilera,CM; Ruiz-Ojeda,FJ] Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, Spain. [Anguita-Ruiz,A; Plaza-Díaz,J; Mendez-Gutierrez,A; Aguilera,CM; Ruiz-Ojeda,FJ] Instituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, Granada, Spain. [Anguita-Ruiz,A; Bustos-Aibar,M; Plaza-Díaz,J; Mendez-Gutierrez,A; Aguilera,CM] Institute of Nutrition and Food Technology “José Mataix”, Center of Biomedical Research, University of Granada, Granada, Spain. [Anguita-Ruiz,A; Mendez-Gutierrez,A; Aguilera,CM] CIBEROBN (CIBER Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain. [Plaza-Díaz,J] Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada. [Alcalá-Fdez,J] Department of Computer Science and Artificial Intelligence, University of Granada, Granada, Spain. [Ruiz-Ojeda,FJ] RG Adipocytes and Metabolism, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Center Munich, Neuherberg, Munich, Germany. | |
dc.contributor.funder | AMG is supported by a doctorate fellowship Formación del Profesorado Universitario (FPU 16/03653)”, which is being completed as part of the Nutrition and Food Sciences Program at the University of Granada, Spain. AAR is supported by a doctorate contract i-PFIS: Doctorados IIS-empresa en ciencias y tecnologías de la salud (IFI17/00048). JPD is supported by a grant to postdoctoral researchers at foreign Universities and Research Centers from the “Ramón-Areces Foundation”, Spain. FJRO is part of the “Personal Investigador Doctor”, University of Granada, funded by Junta de Andalucía (PAIDI, 2020). | |
dc.date.accessioned | 2022-11-29T12:51:59Z | |
dc.date.available | 2022-11-29T12:51:59Z | |
dc.date.issued | 2021-03-09 | |
dc.description.abstract | Extracellular matrix (ECM) remodeling plays important roles in both white adipose tissue (WAT) and the skeletal muscle (SM) metabolism. Excessive adipocyte hypertrophy causes fibrosis, inflammation, and metabolic dysfunction in adipose tissue, as well as impaired adipogenesis. Similarly, disturbed ECM remodeling in SM has metabolic consequences such as decreased insulin sensitivity. Most of described ECM molecular alterations have been associated with DNA sequence variation, alterations in gene expression patterns, and epigenetic modifications. Among others, the most important epigenetic mechanism by which cells are able to modulate their gene expression is DNA methylation. Epigenome-Wide Association Studies (EWAS) have become a powerful approach to identify DNA methylation variation associated with biological traits in humans. Likewise, Genome-Wide Association Studies (GWAS) and gene expression microarrays have allowed the study of whole-genome genetics and transcriptomics patterns in obesity and metabolic diseases. The aim of this review is to explore the molecular basis of ECM in WAT and SM remodeling in obesity and the consequences of metabolic complications. For that purpose, we reviewed scientific literature including all omics approaches reporting genetic, epigenetic, and transcriptomic (GWAS, EWAS, and RNA-seq or cDNA arrays) ECM-related alterations in WAT and SM as associated with metabolic dysfunction and obesity. | es_ES |
dc.description.version | Yes | es_ES |
dc.identifier.citation | Anguita-Ruiz A, Bustos-Aibar M, Plaza-Díaz J, Mendez-Gutierrez A, Alcalá-Fdez J, Aguilera CM, et al. Omics Approaches in Adipose Tissue and Skeletal Muscle Addressing the Role of Extracellular Matrix in Obesity and Metabolic Dysfunction. Int J Mol Sci. 2021 Mar 9;22(5):2756 | es_ES |
dc.identifier.doi | 10.3390/ijms22052756 | es_ES |
dc.identifier.essn | 1422-0067 | |
dc.identifier.issn | 1661-6596 | |
dc.identifier.pmc | PMC7963192 | |
dc.identifier.pmid | 33803198 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10668/4430 | |
dc.journal.title | International Journal of Molecular Sciences | |
dc.language.iso | en | |
dc.page.number | 33 p. | |
dc.publisher | MDPI | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/22/5/2756/htm | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.accessRights | Acceso abierto | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Obesity | es_ES |
dc.subject | Adipose tissue | es_ES |
dc.subject | Extracellular matrix | es_ES |
dc.subject | Skeletal muscle | es_ES |
dc.subject | Genetics | es_ES |
dc.subject | Epigenetic | es_ES |
dc.subject | Transcriptomic | es_ES |
dc.subject | Obesidad | es_ES |
dc.subject | Tejido adiposo | es_ES |
dc.subject | Matriz extracelular | es_ES |
dc.subject | Músculo esquelético | es_ES |
dc.subject | Genética | es_ES |
dc.subject | Epigenómica | es_ES |
dc.subject | Transcriptoma | es_ES |
dc.subject.mesh | Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, White | es_ES |
dc.subject.mesh | Medical Subject Headings::Organisms::Eukaryota::Animals | es_ES |
dc.subject.mesh | Medical Subject Headings::Anatomy::Cells::Cellular Structures::Extracellular Space::Extracellular Matrix | es_ES |
dc.subject.mesh | Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genetic Association Studies::Genome-Wide Association Study | es_ES |
dc.subject.mesh | Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans | es_ES |
dc.subject.mesh | Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases | es_ES |
dc.subject.mesh | Medical Subject Headings::Anatomy::Musculoskeletal System::Muscles::Muscle, Skeletal | es_ES |
dc.subject.mesh | Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity | es_ES |
dc.subject.mesh | Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic | es_ES |
dc.subject.mesh | Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Transcription, Genetic::Transcriptome | es_ES |
dc.title | Omics Approaches in Adipose Tissue and Skeletal Muscle Addressing the Role of Extracellular Matrix in Obesity and Metabolic Dysfunction | es_ES |
dc.type | review article | |
dc.type.hasVersion | VoR | |
dspace.entity.type | Publication |