Publication:
Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases.

dc.contributor.authorGutierrez-Mariscal, Francisco Miguel
dc.contributor.authorArenas-de Larriva, Antonio Pablo
dc.contributor.authorLimia-Perez, Laura
dc.contributor.authorRomero-Cabrera, Juan Luis
dc.contributor.authorYubero-Serrano, Elena Maria
dc.contributor.authorLopez-Miranda, Jose
dc.contributor.funderServicio Andaluz de Salud, Junta de Andalucia
dc.date.accessioned2023-02-09T09:45:24Z
dc.date.available2023-02-09T09:45:24Z
dc.date.issued2020-10-22
dc.description.abstractApart from its main function in the mitochondria as a key element in electron transport, Coenzyme Q10 (CoQ10) has been described as having multiple functions, such as oxidant action in the generation of signals and the control of membrane structure and phospholipid and cellular redox status. Among these, the most relevant and most frequently studied function is the potent antioxidant capability of its coexistent redox forms. Different clinical trials have investigated the effect of CoQ10 supplementation and its ability to reduce oxidative stress. In this review, we focused on recent advances in CoQ10 supplementation, its role as an antioxidant, and the clinical implications that this entails in the treatment of chronic diseases, in particular cardiovascular diseases, kidney disease, chronic obstructive pulmonary disease, non-alcoholic fatty liver disease, and neurodegenerative diseases. As an antioxidant, CoQ10 has proved to be of potential use as a treatment in diseases in which oxidative stress is a hallmark, and beneficial effects of CoQ10 have been reported in the treatment of chronic diseases. However, it is crucial to reach a consensus on the optimal dose and the use of different formulations, which vary from ubiquinol or ubiquinone Ubisol-Q10 or Qter®, to new analogues such as MitoQ, before we can draw a clear conclusion about its clinical use. In addition, a major effort must be made to demonstrate its beneficial effects in clinical trials, with a view to making the implementation of CoQ10 possible in clinical practice.
dc.description.sponsorshipElena M Yubero-Serrano was the recipient of the Nicolas Monardes Programme from the “Servicio Andaluz de Salud, Junta de Andalucia”, Spain (C1-0005-2019).
dc.description.versionSi
dc.identifier.citationGutierrez-Mariscal FM, Arenas-de Larriva AP, Limia-Perez L, Romero-Cabrera JL, Yubero-Serrano EM, López-Miranda J. Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases. Int J Mol Sci. 2020 Oct 23;21(21):7870.
dc.identifier.doi10.3390/ijms21217870
dc.identifier.essn1422-0067
dc.identifier.pmcPMC7660335
dc.identifier.pmid33114148
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660335/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/1422-0067/21/21/7870/pdf?version=1603455764
dc.identifier.urihttp://hdl.handle.net/10668/16494
dc.issue.number21
dc.journal.titleInternational journal of molecular sciences
dc.journal.titleabbreviationInt J Mol Sci
dc.language.isoen
dc.organizationIMIBIC
dc.publisherMDPI AG
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
dc.relation.projectIDC1-0005-2019
dc.relation.publisherversionhttps://www.mdpi.com/resolver?pii=ijms21217870
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCoenzyme Q10
dc.subjectantioxidant capacity
dc.subjectcardiovascular disease
dc.subjectcardiovascular risk factors
dc.subjectchronic obstructive pulmonary disease
dc.subjectkidney disease
dc.subjectneurodegenerative diseases
dc.subjectnon-alcoholic fatty liver disease
dc.subjectoxidative stress
dc.subjectubiquinone
dc.subject.decsEnfermedad crónica
dc.subject.decsEstrés oxidativo
dc.subject.decsSuplementos dietéticos
dc.subject.decsUbiquinona
dc.subject.decsEnsayos clínicos como asunto
dc.subject.meshChronic Disease
dc.subject.meshClinical Trials as Topic
dc.subject.meshDietary Supplements
dc.subject.meshHumans
dc.subject.meshOxidative Stress
dc.subject.meshTreatment Outcome
dc.subject.meshUbiquinone
dc.titleCoenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number21
dspace.entity.typePublication

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