Publication:
Multifocal ERG Guiding Therapy in a Case of Hydroxychloroquine Premaculopathy.

dc.contributor.authorSáez-Moreno, José Antonio
dc.contributor.authorDomínguez-Hidalgo, Concepción
dc.contributor.authorRodríguez-Ferrer, José Manuel
dc.contributor.authoraffiliation[Sáez-Moreno,JA; Domínguez-Hidalgo,C; Rodríguez-Ferrer,JM] Laboratory of Visual and Cognitive Neuroscience, Institute of Neuroscience, Granada University, Granada, Spain. [Sáez-Moreno,JA] Department of Clinical Electrophysiology, San Cecilio University Hospital, Granada, Spain. [Domínguez-Hidalgo,C] Department of Ophthalmology, San Cecilio University Hospital, Granada, Spain. [Rodríguez-Ferrer,JM] Department of Physiology, School of Medicine, Granada University, Granada, Spain.es
dc.contributor.funderThis work was supported by grants from Junta de Andalucía (BIO-195) and European Union (FEDER).
dc.date.accessioned2016-12-05T10:05:31Z
dc.date.available2016-12-05T10:05:31Z
dc.date.issued2015-09-21
dc.descriptionJournal Article;es
dc.description.abstractWe report the case of a 28-year-old female treated for systemic lupus erythematosus with hydroxychloroquine (200 mg/day) for 11 years. She was visually asymptomatic, with normal fundus appearance, normal colour vision testing findings, 20/20 visual acuity in both eyes, and only mild central bilateral defects on 10-2 perimetry. Multifocal electroretinography (mfERG) showed low density values for ring 1 in both eyes. Because the patient had not previously responded to alternative treatments and in consultation with her physician, the hydroxychloroquine dose was reduced to 200 mg four days/week. Four serial mfERGs performed at 4, 18, 25, and 34 months after dose reduction showed a progressive improvement in the definition and density of the responses until they were normalized at the third mfERG (25 months after hydroxychloroquine dose reduction). The fourth and final mfERG at 34 months confirmed the recovery in both eyes. Perimetry defects were mostly normalized. These results demonstrate the importance of mfERG for the safe management of patients under long-term hydroxychloroquine treatment.es
dc.description.versionYeses
dc.identifier.citationSáez-Moreno JA, Domínguez-Hidalgo C, Rodríguez-Ferrer JM. Multifocal ERG Guiding Therapy in a Case of Hydroxychloroquine Premaculopathy. Case Rep Ophthalmol Med; 2015:656928es
dc.identifier.doi10.1155/2015/656928
dc.identifier.essn2090-6722
dc.identifier.pmcPMC4628686
dc.identifier.pmid26557401
dc.identifier.urihttp://hdl.handle.net/10668/2557
dc.journal.titleCase Reports in Ophthalmological Medicine
dc.language.isoen
dc.publisherHindawi Publishing Corporationes
dc.relation.publisherversionHindawi Publishing Corporationes
dc.rights.accessRightsopen access
dc.subjectVisión de coloreses
dc.subjectElectrorretinografíaes
dc.subjectFemeninoes
dc.subjectFondo de ojoes
dc.subjectHumanoses
dc.subjectHidroxicloroquinaes
dc.subjectLupus eritematoso sistémicoes
dc.subjectRemisión y consultaes
dc.subjectAgudeza visuales
dc.subjectPruebas del campo visuales
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Ocular Physiological Phenomena::Ocular Physiological Processes::Vision, Ocular::Color Visiones
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Ophthalmological::Electroretinographyes
dc.subject.meshMedical Subject Headings::Check Tags::Femalees
dc.subject.meshMedical Subject Headings::Anatomy::Sense Organs::Eye::Retina::Fundus Oculies
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Quinolines::Aminoquinolines::Chloroquine::Hydroxychloroquinees
dc.subject.meshMedical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Lupus Erythematosus, Systemices
dc.subject.meshMedical Subject Headings::Health Care::Health Services Administration::Organization and Administration::Professional Practice::Referral and Consultationes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Ocular Physiological Phenomena::Visual Acuityes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Ophthalmological::Vision Tests::Visual Field Testses
dc.titleMultifocal ERG Guiding Therapy in a Case of Hydroxychloroquine Premaculopathy.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication
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