Publication:
Gender Differences in the Presentation and Outcomes of Hospitalized Patients With COVID-19.

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2021

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Biolè, Carloalberto
Bianco, Matteo
Núñez-Gil, Iván J
Cerrato, Enrico
Spirito, Amanda
Roubin, Sergio Raposeiras
Viana-Llamas, María C
Gonzalez, Adelina
Castro-Mejía, Alex F
Eid, Charbel Maroun

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Abstract

Gender-related differences in COVID-19 clinical presentation, disease progression, and mortality have not been adequately explored. We analyzed the clinical profile, presentation, treatments, and outcomes of patients according to gender in the HOPE-COVID-19 International Registry. Among 2,798 enrolled patients, 1,111 were women (39.7%). Male patients had a higher prevalence of cardiovascular risk factors and more comorbidities at baseline. After propensity score matching, 876 men and 876 women were selected. Male patients more often reported fever, whereas female patients more often reported vomiting, diarrhea, and hyposmia/anosmia. Laboratory tests in men presented alterations consistent with a more severe COVID-19 infection (eg, significantly higher C-reactive protein, troponin, transaminases, lymphocytopenia, thrombocytopenia, and ferritin). Systemic inflammatory response syndrome, bilateral pneumonia, respiratory insufficiency, and renal failure were significantly more frequent in men. Men more often required pronation, corticosteroids, and tocilizumab administration. A significantly higher 30-day mortality was observed in men vs women (23.4% vs 19.2%; P = .039). Trial Numbers: NCT04334291/EUPAS34399.

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Aged
Aged, 80 and over
COVID-19
Cohort Studies
Comorbidity
Disease Progression
Female
Heart Disease Risk Factors
Hospitalization
Humans
Male
Middle Aged
Sex Factors

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