Publication:
High density lipoprotein subfractions and extent of coronary atherosclerotic lesions: From the cordioprev study.

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Date

2022-06-03

Authors

de la Cruz-Ares, Silvia
Leon-Acuña, Ana
Yubero-Serrano, Elena M
Torres-Peña, Jose D
Arenas-de Larriva, Antonio P
Cardelo, Magdalena P
Rangel-Zuñiga, Oriol A
Luque, Raul M
Alcala-Diaz, Juan F
Ordovas, Jose M

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Elsevier
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Abstract

The extent of atherosclerotic coronary heart disease (CHD) is associated with its prognosis, thus discovering potential biomarkers related to worse outcomes could prove valuable. The present work aims to investigate whether lipoprotein subfractions are associated with angiographic CHD severity. Patients from the CORDIOPREV study exhibiting coronary lesions in angiography were classified into two groups (single-vessel coronary disease (SVD) or multivessel coronary disease (MVD)). High-throughput nuclear magnetic resonance (NMR) spectroscopy determined lipoprotein subfractions concentration and composition. SVD patients showed a higher concentration of medium and small HDL particles compared with MVD patients. For medium HDL, total lipids, phospholipids, total cholesterol, cholesteryl esters and free cholesterol reflected HDL particle concentration, whereas, for small HDL, total lipids, phospholipids, and free cholesterol mirrored lipoprotein particle concentration. Among traditional cardiovascular risk factors, age, hypertension and T2D were independently associated with angiography severity. In multivariate logistic regression models, medium and small HDL particles remained inversely associated with angiography severity (OR 0.77 (95% CI: 0.64-0.91); OR 0.78 (95% CI: 0.67-0.91), respectively) after adjusting with covariates. In CHD patients mostly on statin treatment, angiography severity is inversely related to small and medium HDL subclasses concentration measured by NMR. These particles are also independent predictors of the presence of MVD, and its use increased the prediction of this entity over traditional risk factors.

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MeSH Terms

Atherosclerosis
Cholesterol
Cholesterol, HDL
Coronary artery disease
Humans
Lipoproteins
Lipoproteins, HDL

DeCS Terms

Aterosclerosis
Colesterol
Enfermedad de la arteria coronaria
HDL-colesterol
Humanos
Lipoproteínas
Lipoproteínas HDL

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Keywords

Angiography severity, Atherosclerosis, Cardiovascular risk factors, HDL particles, Lipoprotein subfractions

Citation

de la Cruz-Ares S, Leon-Acuña A, Yubero-Serrano EM, Torres-Peña JD, Arenas-de Larriva AP, Cardelo MP, et al. High density lipoprotein subfractions and extent of coronary atherosclerotic lesions: From the cordioprev study. Clin Chim Acta. 2022 Aug 1;533:89-95