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Expression of the long non-coding RNA TCL6 is associated with clinical outcome in pediatric B-cell acute lymphoblastic leukemia.

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dc.contributor.authorCuadros, Marta
dc.contributor.authorAndrades, Alvaro
dc.contributor.authorCoira, Isabel F
dc.contributor.authorBaliñas, Carlos
dc.contributor.authorRodriguez, Maria I
dc.contributor.authorAlvarez-Perez, Juan Carlos
dc.contributor.authorPeinado, Paola
dc.contributor.authorArenas, Alberto M
dc.contributor.authorGarcia, Daniel J
dc.contributor.authorJimenez, Pilar
dc.contributor.authorCamos, Mireia
dc.contributor.authorJimenez-Velasco, Antonio
dc.contributor.authorMedina, Pedro P
dc.contributor.funderMinistry of Economy of Spain
dc.contributor.funderConsejería de Salud de la Junta de Andalucía
dc.contributor.funderLa Caixa Foundation
dc.date.accessioned2023-02-08T14:37:48Z
dc.date.available2023-02-08T14:37:48Z
dc.date.issued2019-11-25
dc.description.abstractAcute lymphoblastic leukemia (ALL) is a clinically and biologically heterogeneous disease recurrently affected by chromosomal aberrations, including translocations, amplifications, and aneuploidies1. These aberrations have important implications for the diagnosis, sub-classification, prognosis and, overall, for making appropriate therapeutic decisions. The reciprocal translocation t(12;21)(p13;q22)[ETV6/RUNX1] is the most frequent chromosomal rearrangement in pediatric B-cell acute lymphoblastic leukemia (B-ALL) with an incidence of ~25%2. This rearrangement, as well as high hyperdiploidy, is associated with a favorable outcome under current treatment protocols, but up to 20% of ETV6-RUNX1positive pediatric B-ALL patients experience a late disease relapse1,3.
dc.description.sponsorshipThe authors would like to thank the Deutsche José Carreras Leukämie-Stiftung, Inocente Inocente Foundation, the Ministry of Economy of Spain SAF201567919-R), Consejería de Salud de la Junta de Andalucía (Pl-0245-2017, CS20163), BBVA Foundation, Francisco-Cobos Foundation, Fero Foundation and AECC Foundation for funding Pedro P. Medinas’s lab. Álvaro Andrades is supported by an FPU17/00067 PhD fellowship, Alberto M. Arenas is supported by an FPU17/01258 PhD fellowship, Paola Peinado is supported by a La Caixa Foundation PhD Fellowship (LCF/BQ/DE15/10360019), Isabel F. Coira was supported by a PhD FPI-fellowship (BES-2013-064596), Daniel J. García is supported by a Fundación Benéfica Anticáncer Santa Cándida y San Francisco Javier PhD fellowship and Juan Carlos Álvarez-Pérez is supported by a Marie Sklodowska Curie action (H2020-MSCA-IF-2018).
dc.description.versionSi
dc.identifier.citationCuadros M, Andrades Á, Coira IF, Baliñas C, Rodríguez MI, Álvarez-Pérez JC, et al. Expression of the long non-coding RNA TCL6 is associated with clinical outcome in pediatric B-cell acute lymphoblastic leukemia. Blood Cancer J. 2019 Nov 25;9(12):93
dc.identifier.doi10.1038/s41408-019-0258-9
dc.identifier.essn2044-5385
dc.identifier.pmcPMC6877621
dc.identifier.pmid31767830
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877621/pdf
dc.identifier.unpaywallURLhttps://www.nature.com/articles/s41408-019-0258-9.pdf
dc.identifier.urihttp://hdl.handle.net/10668/14742
dc.issue.number12
dc.journal.titleBlood cancer journal
dc.journal.titleabbreviationBlood Cancer J
dc.language.isoen
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationCentro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica-GENYO
dc.organizationHospital Universitario Regional de Málaga
dc.page.number93
dc.provenanceRealizada la curación de contenido 18/02/2025
dc.publisherNature Publishing Group
dc.pubmedtypeLetter
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.projectIDSAF201567919-R
dc.relation.projectIDPl-0245-2017
dc.relation.projectIDCS20163
dc.relation.projectIDFPU17/00067
dc.relation.projectIDFPU17/01258
dc.relation.projectIDLCF/BQ/DE15/10360019
dc.relation.publisherversionhttps://doi.org/10.1038/s41408-019-0258-9
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBiomarkers, Tumor
dc.subjectCore Binding Factor Alpha 2 Subunit
dc.subjectGene Expression Profiling
dc.subjectGene Expression Regulation, Neoplastic
dc.subject.decsLeucemia-linfoma linfoblástico de células precursoras
dc.subject.decsAberraciones cromosómicas
dc.subject.decsProtocolos clínicos
dc.subject.decsCélulas
dc.subject.decsClasificación
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshOncogene Proteins, Fusion
dc.subject.meshPrecursor B-Cell Lymphoblastic Leukemia-Lymphoma
dc.subject.meshPrognosis
dc.subject.meshRNA Interference
dc.subject.meshRNA, Long Noncoding
dc.titleExpression of the long non-coding RNA TCL6 is associated with clinical outcome in pediatric B-cell acute lymphoblastic leukemia.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number9
dspace.entity.typePublication

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