Publication:
Therapeutic plasma exchange with albumin: a new approach to treat Alzheimer's disease.

No Thumbnail Available

Date

2021-08-04

Authors

Boada, Mercè
Martinez-Lage, Pablo
Serrano-Castro, Pedro
Costa, Montserrat
Páez, Antonio

Advisors

Journal Title

Journal ISSN

Volume Title

Publisher

Taylor & Francis
Metrics
Google Scholar
Export

Research Projects

Organizational Units

Journal Issue

Abstract

Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most common cause of dementia. It has a complex pathophysiology that is not yet completely understood, where multiple central, systemic, and environmental factors play a key role in disease progression. Understanding the multifactorial nature of AD is paramount to formulate new therapies. The authors reviewed the role of the amyloid-β-binding, antioxidant, and immunomodulatory properties of albumin in AD and the use of therapeutic plasma exchange (PE) in neurology. The results from the Alzheimer Management By Albumin Replacement (AMBAR) trial that combined the use of PE with albumin replacement in patients with mild-to-moderate AD, are also analyzed. Findings from the AMBAR study provide encouraging results in the treatment of AD with PE and albumin replacement, especially in patients at the moderate stage of the disease, who showed less cognitive decline from baseline compared with placebo in most of the variables analyzed. Further research is warranted to ascertain the possible mechanisms of action underlying these results. Different cohorts of patients that may also benefit from this treatment, such as those with mild cognitive impairment or other types of dementia, could also be the target of additional studies.

Description

MeSH Terms

Albumins
Alzheimer disease
Amyloid beta-peptides
Biomarkers
Cognitive dysfunction
Disease progression
Humans
Plasma exchange

DeCS Terms

Albúminas
Biomarcadores
Disfunción cognitiva
Enfermedad de Alzheimer
Intercambio plasmático
Progresión de la enfermedad
Péptidos beta-amiloides

CIE Terms

Keywords

Alzheimer’s disease, albumin, amyloid-β, neurodegenerative disease, plasma exchange, therapeutic plasma exchange

Citation

Boada M, Martínez-Lage P, Serrano-Castro P, Costa M, Páez A. Therapeutic plasma exchange with albumin: a new approach to treat Alzheimer's disease. Expert Rev Neurother. 2021 Aug;21(8):843-849