Publication: Therapeutic plasma exchange with albumin: a new approach to treat Alzheimer's disease.
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Identifiers
Date
2021-08-04
Authors
Boada, Mercè
Martinez-Lage, Pablo
Serrano-Castro, Pedro
Costa, Montserrat
Páez, Antonio
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis
Abstract
Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most common cause of dementia. It has a complex pathophysiology that is not yet completely understood, where multiple central, systemic, and environmental factors play a key role in disease progression. Understanding the multifactorial nature of AD is paramount to formulate new therapies. The authors reviewed the role of the amyloid-β-binding, antioxidant, and immunomodulatory properties of albumin in AD and the use of therapeutic plasma exchange (PE) in neurology. The results from the Alzheimer Management By Albumin Replacement (AMBAR) trial that combined the use of PE with albumin replacement in patients with mild-to-moderate AD, are also analyzed. Findings from the AMBAR study provide encouraging results in the treatment of AD with PE and albumin replacement, especially in patients at the moderate stage of the disease, who showed less cognitive decline from baseline compared with placebo in most of the variables analyzed. Further research is warranted to ascertain the possible mechanisms of action underlying these results. Different cohorts of patients that may also benefit from this treatment, such as those with mild cognitive impairment or other types of dementia, could also be the target of additional studies.
Description
MeSH Terms
Albumins
Alzheimer disease
Amyloid beta-peptides
Biomarkers
Cognitive dysfunction
Disease progression
Humans
Plasma exchange
Alzheimer disease
Amyloid beta-peptides
Biomarkers
Cognitive dysfunction
Disease progression
Humans
Plasma exchange
DeCS Terms
Albúminas
Biomarcadores
Disfunción cognitiva
Enfermedad de Alzheimer
Intercambio plasmático
Progresión de la enfermedad
Péptidos beta-amiloides
Biomarcadores
Disfunción cognitiva
Enfermedad de Alzheimer
Intercambio plasmático
Progresión de la enfermedad
Péptidos beta-amiloides
CIE Terms
Keywords
Alzheimer’s disease, albumin, amyloid-β, neurodegenerative disease, plasma exchange, therapeutic plasma exchange
Citation
Boada M, Martínez-Lage P, Serrano-Castro P, Costa M, Páez A. Therapeutic plasma exchange with albumin: a new approach to treat Alzheimer's disease. Expert Rev Neurother. 2021 Aug;21(8):843-849