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Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer.

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dc.contributor.authorGrenville, Zoe S
dc.contributor.authorNoor, Urwah
dc.contributor.authorHis, Mathilde
dc.contributor.authorViallon, Vivian
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorAglago, Elom K
dc.contributor.authorAmiano, Pilar
dc.contributor.authorBrunkwall, Louise
dc.contributor.authorChirlaque, María Dolores
dc.contributor.authorDrake, Isabel
dc.contributor.authorEichelmann, Fabian
dc.contributor.authorFreisling, Heinz
dc.contributor.authorGrioni, Sara
dc.contributor.authorHeath, Alicia K
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKatzke, Verena
dc.contributor.authorMayén-Chacon, Ana-Lucia
dc.contributor.authorMilani, Lorenzo
dc.contributor.authorMoreno-Iribas, Conchi
dc.contributor.authorPala, Valeria
dc.contributor.authorOlsen, Anja
dc.contributor.authorSanchez-Perez, Maria-Jose
dc.contributor.authorSchulze, Matthias B
dc.contributor.authorTjønneland, Anne
dc.contributor.authorTsilidis, Konstantinos K
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorWinkvist, Anna
dc.contributor.authorZamora-Ros, Raul
dc.contributor.authorKey, Timothy J
dc.contributor.authorSmith-Byrne, Karl
dc.contributor.authorTravis, Ruth C
dc.contributor.authorSchmidt, Julie A
dc.contributor.funderCancer Research UK
dc.contributor.funderInternational Agency for Research on Cancer (IARC)
dc.contributor.funderDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London
dc.contributor.funderNIHR Imperial Biomedical Research Centre (BRC)
dc.contributor.funderDanish Cancer Society
dc.contributor.funderLigue Contre le Cancer, Institut Gustave Roussy
dc.contributor.funderMutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM)
dc.contributor.funderGerman Cancer Aid
dc.contributor.funderGerman Cancer Research Center (DKFZ)
dc.contributor.funderGerman Institute of Human Nutrition PotsdamRehbruecke (DIfE)
dc.contributor.funderFederal Ministry of Education and Research (BMBF)
dc.contributor.funderAssociazione Italiana per la Ricerca sul Cancro-AIRC-Italy,
dc.contributor.funderCompagnia di SanPaolo and National Research Council
dc.contributor.funderDutch Ministry of Public Health, Welfare and Sports (VWS)
dc.contributor.funderWorld Cancer Research Fund (WCRF)
dc.contributor.funderInstituto de Salud Carlos III (ISCIII)
dc.contributor.funderRegional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology—ICO (Spain)
dc.contributor.funderSwedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden)
dc.contributor.funderCancer Research UK
dc.contributor.funderMedical Research Council
dc.date.accessioned2023-05-03T14:17:51Z
dc.date.available2023-05-03T14:17:51Z
dc.date.issued2022-08-10
dc.description.abstractThree metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern 1), acylcarnitines C18:1 and C18:2, glutamate, ornithine, and taurine (Pattern 2), and 8 lysophosphatidylcholines (Pattern 3). In a two-stage cross-sectional discovery (n = 2524) and validation (n = 518) design containing 3042 men free of cancer in EPIC, we estimated the associations of 24 dietary and lifestyle variables with each pattern and the contributing individual metabolites. Associations statistically significant after both correction for multiple testing (False Discovery Rate = 0.05) in the discovery set and at p
dc.description.sponsorship: This work was supported by Cancer Research UK [C8221/A30904 and C8221/A29017]. The coordination of EPIC is financially supported by International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition PotsdamRehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF) (The Netherlands); Health Research Fund (FIS)—Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology—ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); and Cancer Research UK (14136 to EPIC-Norfolk (DOI 10.22025/2019.10.105.00004); C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143, MR/N003284/1, MC-UU_12015/1 and MC_UU_00006/1 to EPIC-Norfolk; MR/M012190/1 to EPICOxford) (UK). The funders were not involved in designing the study; collecting, analyzing, or interpreting the data; or writing or submitting the manuscript for publication.
dc.description.versionSi
dc.identifier.citationGrenville ZS, Noor U, His M, Viallon V, Rinaldi S, Aglago EK, Amiano P, et al.Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer. Nutrients. 2022 Aug 12;14(16):3306.
dc.identifier.doi10.3390/nu14163306
dc.identifier.essn2072-6643
dc.identifier.pmcPMC9415102
dc.identifier.pmid36014812
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9415102/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2072-6643/14/16/3306/pdf?version=1660298028
dc.identifier.urihttp://hdl.handle.net/10668/21494
dc.issue.number16
dc.journal.titleNutrients
dc.journal.titleabbreviationNutrients
dc.language.isoen
dc.organizationEscuela Andaluza de Salud Pública-EASP
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number3306
dc.provenanceRealizada la curación de contenido 05/03/2025
dc.publisherMDPI AG
dc.pubmedtypeJournal Article
dc.relation.projectIDC8221/A30904
dc.relation.projectIDC8221/A29017
dc.relation.projectID14136
dc.relation.projectIDC8221/A29017
dc.relation.projectID1000143
dc.relation.projectIDMR/N003284/1
dc.relation.projectIDMC-UU_12015/1
dc.relation.projectIDMC_UU_00006/1
dc.relation.projectIDMR/M012190/1
dc.relation.publisherversionhttps://www.mdpi.com/resolver?pii=nu14163306
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectcross-sectional
dc.subjectdiet
dc.subjectmetabolites
dc.subjectprostate cancer
dc.subject.decsGlutamatos
dc.subject.decsNeoplasias de la próstata
dc.subject.decsDieta
dc.subject.decsMasculino
dc.subject.decsÍndice de masa corporal
dc.subject.meshAnimals
dc.subject.meshBody Mass Index
dc.subject.meshCross-Sectional Studies
dc.subject.meshDiet
dc.subject.meshFishes
dc.subject.meshGlutamates
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshProspective Studies
dc.subject.meshProstatic Neoplasms
dc.subject.meshRisk Factors
dc.titleDiet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number14
dspace.entity.typePublication
person.affiliation.name[Sanchez-Perez,MJ] Escuela Andaluza de Salud Pública (EASP), 18011 Granada, Spain.
person.affiliation.name[Sanchez-Perez,MJ] Instituto de Investigación Biosanitaria ibs.GRANADA, 18012 Granada, Spain.
person.affiliation.name[Sanchez-Perez,MJ] Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.
person.affiliation.name[Sanchez-Perez,MJ] Department of Preventive Medicine and Public Health, University of Granada, 18071 Granada, Spain.

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