Publication:
The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

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dc.contributor.authorCampa, Daniele
dc.contributor.authorHüsing, Anika
dc.contributor.authorMcKay, James D
dc.contributor.authorSinilnikova, Olga
dc.contributor.authorVogel, Ulla
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOvervad, Kim
dc.contributor.authorStegger, Jakob
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorChabbert-Buffet, Nathalie
dc.contributor.authorFagherazzi, Guy
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorZylis, Dimosthenis
dc.contributor.authorOustoglou, Erifili
dc.contributor.authorRohrmann, Sabine
dc.contributor.authorTeucher, Birgit
dc.contributor.authorFisher, Eva
dc.contributor.authorBoeing, Heiner
dc.contributor.authorMasala, Giovanna
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorSacerdote, Carlota
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorOnland-Moret, Charlotte
dc.contributor.authorvan Gils, Carla H
dc.contributor.authorBueno de Mesquita, H Bas
dc.contributor.authorLund, Eiliv
dc.contributor.authorChirlaque, María D
dc.contributor.authorSala, Nuria
dc.contributor.authorQuirós, José R
dc.contributor.authorArdanaz, Eva
dc.contributor.authorAmiano, Pilar
dc.contributor.authorMolina-Montes, Esther
dc.contributor.authorHallmans, Göran
dc.contributor.authorLenner, Per
dc.contributor.authorTravis, Ruth C
dc.contributor.authorKey, Timothy J
dc.contributor.authorWareham, Nick
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorSlimani, Nadia
dc.contributor.authorChajes, Veronique
dc.contributor.authorSiddiq, Afshan
dc.contributor.authorRiboli, Elio
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorCanzian, Federico
dc.contributor.authoraffiliation[Campa D, Hüssing A, Rohrmann S, Teucher B, Kaaks R, Canzian F] German Cancer Research Center (DKFZ), Heidelberg, Germany. [McKay JD, Slimani N, Chajes V] International Agency for Research on Cancer, Lyon, France. [Sinilnikova O] Hospices Civils de Lyon/Centre Léon Bérard, UMR5201 CNRS-Université Claude Bernard, Lyon, France. [Vogel U] National Food Institute Technical University of Denmark, Denmark. [Tjønneland A] Danish Cancer Society, Copenhagen, Denmark. [Overvad K] Aarhus University Hospital, Aalborg, Denmark. [Stegger J] Department of Cardiology, Cardiovascular Research Centre, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark. [Clavel-Chapelon F, Chabbert-Buffet N, Fagherazzi G] Institut Gustave Roussy, Villejuif, France. [Trichopoulou A, Zylis D] WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece. [Trichopoulou A, Oustoglou E] Hellenic Health Foundation, Athens, Greece. [Fisher E, Boeing H] German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany. [Masala G] Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy. [Krogh V] Istituto Nazionale dei Tumori (IRCCS), Milan, Italy. [Sacerdote C] CPO Piemonte, Turin, Italy. [Panico S] Department of Clinical and Experimental Medicine Federico II University, Naples, Italy. [Tumino R] Azienda Ospedaliera "Civile M.P.Arezzo" Ragusa, Italy. [Onland-Moret NC, van Gils CH] Julius Center, University Medical Center, Utrecht, The Netherlands. [Bueno-de-Mesquita HB] National Institute for Public Health and the Environment, Bilthoven, The Netherlands. [Lund E] Institute of Community Medicine University of Tromsø, Tromsø, Norway. [Chirlaque MD] Murcia Regional Health Council, Murcia, Spain. [Sala N] Catalan Institute of Oncology, Barcelona, Spain. [Quirós JR] Consejería de Salud y Servicios Sanitarios Principado de Asturias, Oviedo, Spain. [Ardanaz E] Public Health Institute of Navarra, Pamplona, Spain. [Amiano P] Public Health Department of Gipuzkoa, San Sebastian, Spain. [Molina-Montes E] Andalusian School of Public Health, Granada, Spain. [Chirlaque MD, Amiano P, Molina-Montes E] CIBER de Epidemiología y Salud Pública (CIBERESP), Spain. [Hallmans G, Lenner2 P] Umeå University, Umeå, Sweden. [Travis RC, Key TJ] Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK OX3 7LF. [Wareham N, Khaw KT] University of Cambridge, Cambridge, UK. [Siddiq A, Riboli E] Imperial College, London, UK.
dc.date.accessioned2012-01-16T12:53:57Z
dc.date.available2012-01-16T12:53:57Z
dc.date.issued2010-10-18
dc.description.abstractBackground The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought to validate the association of rs7566605 with various markers of obesity, with several publications reporting inconsistent findings. BMI is considered to be one of the measures of choice to evaluate body fatness and there is evidence that body fatness is related with an increased risk of breast cancer (BC). Methods we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk. Results and Conclusions In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status.es
dc.description.versionYeses
dc.identifier.citationCampa D, Hüsing A, McKay JD, Sinilnikova O, Vogel U, Tjønneland A, et al. The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. BMC Cancer. 2010 Oct 18; 10:563es
dc.identifier.doi10.1186/1471-2407-10-563
dc.identifier.pmid20955599
dc.identifier.urihttp://hdl.handle.net/10668/278
dc.journal.titleBMC Cancer
dc.language.isoen
dc.publisherBiomed Centrales
dc.relation.publisherversionhttp://www.biomedcentral.com/1471-2407/10/563es
dc.rights.accessRightsopen access
dc.subjectNeoplasias de la mamaes
dc.subjectÍndice de masa musculares
dc.subjectPolimorfismo Genéticoes
dc.subjectEstudio de Asociación del Genoma Completoes
dc.subjectEstudios de cohorteses
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasmses
dc.subject.meshMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Biometry::Anthropometry::Body Mass Indexes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetices
dc.subject.meshMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Research Design::Genome-Wide Association Studyes
dc.subject.meshMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studieses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteinses
dc.titleThe INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer riskes
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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