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Vanadium Decreases Hepcidin mRNA Gene Expression in STZ-Induced Diabetic Rats, Improving the Anemic State

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dc.contributor.authorSánchez-González, Cristina
dc.contributor.authorRivas-García, Lorenzo
dc.contributor.authorRodríguez-Nogales, Alba
dc.contributor.authorAlgieri, Francesca
dc.contributor.authorGálvez, Julio
dc.contributor.authorAranda, Pilar
dc.contributor.authorMontes-Bayón, María
dc.contributor.authorLlopis, Juan
dc.contributor.authoraffiliation[Sánchez-González,C; Rivas-García,L; Aranda,P; Llopis,J] Biomedical Research Centre (CIBM), Sport and Health Research Centre (IMUDs), Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Granada, Spain. [Rodríguez-Nogales,A; Algieri,F] CIBERehd, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Department of Pharmacology, CIBM, University of Granada, Granada, Spain. [Montes-Bayón,M] Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Oviedo, Spain
dc.contributor.funderWe are grateful for the support received from the Consejería de Innovación, Ciencia y Empresa, Andalusian Regional Government (Project P06-CTS-01435), and from the Spanish Ministry of Economy and Competitivity (SAF2011-29648); the CIBERehd is funded by the Instituto de Salud Carlos III.
dc.date.accessioned2022-11-21T12:50:18Z
dc.date.available2022-11-21T12:50:18Z
dc.date.issued2021-04-11
dc.description.abstractDiabetes is a disease with an inflammatory component that courses with an anemic state. Vanadium (V) is an antidiabetic agent that acts by stimulating insulin signaling. Hepcidin blocks the intestinal absorption of iron and the release of iron from its deposits. We aim to investigate the effect of V on hepcidin mRNA expression and its consequences on the hematological parameters in streptozotocin-induced diabetic Wistar rats. Control healthy rats, diabetic rats, and diabetic rats treated with 1 mgV/day were examined for five weeks. The mineral levels were measured in diet and serum samples. Hepcidin expression was quantified in liver samples. Inflammatory and hematological parameters were determined in serum or whole blood samples. The inflammatory status was higher in diabetic than in control rats, whereas the hematological parameters were lower in the diabetic rats than in the control rats. Hepcidin mRNA expression was significantly lower in the V-treated diabetic rats than in control and untreated diabetic rats. The inflammatory status remained at a similar level as the untreated diabetic group. However, the hematological profile improved after the V-treatment, reaching similar levels to those found in the control group. Serum iron level was higher in V-treated than in untreated diabetic rats. We conclude that V reduces gene expression of hepcidin in diabetic rats, improving the anemic state caused by diabetes.es_ES
dc.description.versionYeses_ES
dc.identifier.citationSánchez-González C, Rivas-García L, Rodríguez-Nogales A, Algieri F, Gálvez J, Aranda P, et al. Vanadium Decreases Hepcidin mRNA Gene Expression in STZ-Induced Diabetic Rats, Improving the Anemic State. Nutrients. 2021 Apr 11;13(4):1256es_ES
dc.identifier.doi10.3390/nu13041256es_ES
dc.identifier.essn2072-6643
dc.identifier.pmcPMC8069891
dc.identifier.pmid33920401es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4379
dc.journal.titleNutrients
dc.language.isoen
dc.page.number11 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/13/4/1256es_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsAcceso abiertoes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectVanadiumes_ES
dc.subjectHepcidines_ES
dc.subjectInflammationes_ES
dc.subjectAnemiaes_ES
dc.subjectDiabeteses_ES
dc.subjectRatses_ES
dc.subjectIrones_ES
dc.subjectmRNAes_ES
dc.subjectIntestinal absorptiones_ES
dc.subjectGene expressiones_ES
dc.subjectVanadioes_ES
dc.subjectHepcidines_ES
dc.subjectInflamaciónes_ES
dc.subjectRatases_ES
dc.subjectHierroes_ES
dc.subjectARN mensajeroes_ES
dc.subjectAbsorción intestinales_ES
dc.subjectExpresión génicaes_ES
dc.subject.meshMedical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Anemiaes_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses_ES
dc.subject.meshMedical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Experimentales_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulationes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Iron-Regulatory Proteins::Hepcidinses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hypoglycemic Agentses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Absorption::Intestinal Absorptiones_ES
dc.subject.meshMedical Subject Headings::Anatomy::Digestive System::Gastrointestinal Tract::Intestines::Intestinal Mucosaes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Metals, Heavy::Irones_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messengeres_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Ratses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Nitroso Compounds::Nitrosourea Compounds::Streptozocines_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Metals, Heavy::Vanadiumes_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Ratses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Control Groupses_ES
dc.subject.meshMedical Subject Headings::Anatomy::Digestive System::Liveres_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pancreatic Hormones::Insulinses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Mineralses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Dietes_ES
dc.titleVanadium Decreases Hepcidin mRNA Gene Expression in STZ-Induced Diabetic Rats, Improving the Anemic Statees_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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