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Validation of the HIV Tropism Test TROCAI Using the Virological Response to a Short-Term Maraviroc Monotherapy Exposure.

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dc.contributor.authorGonzalez-Serna, A
dc.contributor.authorGenebat, M
dc.contributor.authorDe-Luna-Romero, M
dc.contributor.authorTarancon-Diez, L
dc.contributor.authorDominguez-Molina, B
dc.contributor.authorPacheco, Y M
dc.contributor.authorMuñoz-Fernandez, M A
dc.contributor.authorLeal, M
dc.contributor.authorRuiz-Mateos, E
dc.contributor.funderRedes Telemáticas de Investigación Cooperativa en Salud
dc.contributor.funderPfizer/ViiV Healthcare
dc.date.accessioned2023-01-25T08:35:00Z
dc.date.available2023-01-25T08:35:00Z
dc.date.issued2016-09-23
dc.description.abstractTROCAI is a phenotypic tropism test developed using the virological response to a short-term exposure to maraviroc monotherapy (Maraviroc Clinical Test [MCT]). It was found that with TROCAI, a cutoff of <0.5% of dual/mixed viruses was needed to predict R5 HIV tropism. Here, we have validated TROCAI, using this cutoff, in a new cohort of 42 patients, finding a very high concordance between TROCAI and MCT (98%), and a good concordance (71 to 87%) with other genotypic/phenotypic methods.
dc.description.sponsorshipWe are grateful to all the patients who have participated in this study and to Marien Sanchez and Magdalena Rodriguez for their clinical support. Samples from patients were kindly provided by the HIV BioBank integrated in the Spanish AIDS Research Network (RIS). This work was supported by Redes Telemáticas de Investigación Cooperativa en Salud (RETICS; 2006, Red de SIDA RD06/0006/0021, 2007–2010 and RD16/0025/0020) and Pfizer/ViiV Healthcare (grants WS843473 and WS2425049). A.G.-S. is supported by Instituto de Salud Carlos III (CD14/00320). E.R.-M. has a grant from Fondo de Investigaciones Sanitarias (CD014/0025).
dc.description.versionSi
dc.identifier.citationGonzalez-Serna A, Genebat M, De Luna-Romero M, Tarancon-Diez L, Dominguez-Molina B, Pacheco YM, et al. Validation of the HIV Tropism Test TROCAI Using the Virological Response to a Short-Term Maraviroc Monotherapy Exposure. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6398-401.
dc.identifier.doi10.1128/AAC.01326-16
dc.identifier.essn1098-6596
dc.identifier.pmcPMC5038326
dc.identifier.pmid27480849
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038326/pdf
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc5038326?pdf=render
dc.identifier.urihttp://hdl.handle.net/10668/10329
dc.issue.number10
dc.journal.titleAntimicrobial agents and chemotherapy
dc.journal.titleabbreviationAntimicrob Agents Chemother
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen del Rocío
dc.page.number6398-6401
dc.provenanceRealizada la curación de contenido 30/07/2025.
dc.publisherAmerican Society for Microbiology
dc.pubmedtypeJournal Article
dc.pubmedtypeValidation Study
dc.relation.projectIDRD06/0006/0021
dc.relation.projectIDRD16/0025/0020
dc.relation.projectIDWS843473
dc.relation.projectIDWS2425049
dc.relation.publisherversionhttps://journals.asm.org/doi/10.1128/AAC.01326-16?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
dc.rights.accessRightsRestricted Access
dc.subjectHIV tropism
dc.subjectMaraviroc
dc.subjectMonotherapy
dc.subjectPhenotypic test
dc.subjectVirological response
dc.subjectHIV drug resistance
dc.subjectDiagnostic accuracy
dc.subject.decsVIH
dc.subject.decsTropismo viral
dc.subject.decsMonoterapia
dc.subject.decsPruebas fenotípicas
dc.subject.decsResistencia a medicamentos antirretrovirales
dc.subject.decsCarga viral
dc.subject.decsValidación clínica
dc.subject.meshCyclohexanes
dc.subject.meshHIV
dc.subject.meshHIV Fusion Inhibitors
dc.subject.meshHumans
dc.subject.meshInhibitory Concentration 50
dc.subject.meshMaraviroc
dc.subject.meshTriazoles
dc.subject.meshViral Tropism
dc.subject.meshVirology
dc.titleValidation of the HIV Tropism Test TROCAI Using the Virological Response to a Short-Term Maraviroc Monotherapy Exposure.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number60
dspace.entity.typePublication

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