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Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe.

dc.contributor.authorForns, Joan
dc.contributor.authorSunyer, Jordi
dc.contributor.authorGarcia-Esteban, Raquel
dc.contributor.authorPorta, Daniela
dc.contributor.authorGhassabian, Akhgar
dc.contributor.authorGiorgis-Allemand, Lise
dc.contributor.authorGong, Tong
dc.contributor.authorGehring, Ulrike
dc.contributor.authorSørensen, Mette
dc.contributor.authorStandl, Marie
dc.contributor.authorSugiri, Dorothee
dc.contributor.authorAlmqvist, Catarina
dc.contributor.authorAndiarena, Ainara
dc.contributor.authorBadaloní, Chiara
dc.contributor.authorBeelen, Rob
dc.contributor.authorBerdel, Dietrich
dc.contributor.authorCesaroni, Giulia
dc.contributor.authorCharles, Marie-Aline
dc.contributor.authorEriksen, Kirsten Thorup
dc.contributor.authorEstarlich, Marisa
dc.contributor.authorFernandez, Mariana F
dc.contributor.authorForhan, Anne
dc.contributor.authorJaddoe, Vincent W V
dc.contributor.authorKorek, Michal
dc.contributor.authorLichtenstein, Paul
dc.contributor.authorLertxundi, Aitana
dc.contributor.authorLopez-Espinosa, Maria-Jose
dc.contributor.authorMarkevych, Iana
dc.contributor.authorde Nazelle, Audrey
dc.contributor.authorRaaschou-Nielsen, Ole
dc.contributor.authorNieuwenhuijsen, Mark
dc.contributor.authorPérez-Lobato, Rocío
dc.contributor.authorPhilippat, Claire
dc.contributor.authorSlama, Rémy
dc.contributor.authorTiesler, Carla M T
dc.contributor.authorVerhulst, Frank C
dc.contributor.authorvon Berg, Andrea
dc.contributor.authorVrijkotte, Tanja
dc.contributor.authorNybo Andersen, Anne-Marie
dc.contributor.authorHeude, Barbara
dc.contributor.authorKrämer, Ursula
dc.contributor.authorHeinrich, Joachim
dc.contributor.authorTiemeier, Henning
dc.contributor.authorForastiere, Francesco
dc.contributor.authorPershagen, Göran
dc.contributor.authorBrunekreef, Bert
dc.contributor.authorGuxens, Mònica
dc.date.accessioned2023-01-25T10:20:28Z
dc.date.available2023-01-25T10:20:28Z
dc.date.issued2018-05-30
dc.description.abstractExposure to air pollution during pregnancy may increase attention-deficit/hyperactivity disorder (ADHD) symptoms in children, but findings have been inconsistent. We aimed to study this association in a collaborative study of eight European population-based birth/child cohorts, including 29,127 mother-child pairs. Air pollution concentrations (nitrogen dioxide [NO2] and particulate matter [PM]) were estimated at the birth address by land-use regression models based on monitoring campaigns performed between 2008 and 2011. We extrapolated concentrations back in time to exact pregnancy periods. Teachers or parents assessed ADHD symptoms at 3-10 years of age. We classified children as having ADHD symptoms within the borderline/clinical range and within the clinical range using validated cutoffs. We combined all adjusted area-specific effect estimates using random-effects meta-analysis and multiple imputations and applied inverse probability-weighting methods to correct for loss to follow-up. We classified a total of 2,801 children as having ADHD symptoms within the borderline/clinical range, and 1,590 within the clinical range. Exposure to air pollution during pregnancy was not associated with a higher odds of ADHD symptoms within the borderline/clinical range (e.g., adjusted odds ratio [OR] for ADHD symptoms of 0.95, 95% confidence interval [CI] = 0.89, 1.01 per 10 µg/m increase in NO2 and 0.98, 95% CI = 0.80, 1.19 per 5 µg/m increase in PM2.5). We observed similar associations for ADHD within the clinical range. There was no evidence for an increase in risk of ADHD symptoms with increasing prenatal air pollution levels in children aged 3-10 years. See video abstract at, http://links.lww.com/EDE/B379.
dc.description.versionSi
dc.identifier.citationForns J, Sunyer J, Garcia-Esteban R, Porta D, Ghassabian A, Giorgis-Allemand L, et al. Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe. Epidemiology. 2018 Sep;29(5):618-626.
dc.identifier.doi10.1097/EDE.0000000000000874
dc.identifier.essn1531-5487
dc.identifier.pmid29923866
dc.identifier.unpaywallURLhttps://epub.ub.uni-muenchen.de/64535/1/00001648-201809000-00004.pdf
dc.identifier.urihttp://hdl.handle.net/10668/12616
dc.issue.number5
dc.journal.titleEpidemiology (Cambridge, Mass.)
dc.journal.titleabbreviationEpidemiology
dc.language.isoen
dc.organizationInstituto de Investigación Biosanitaria ibs. GRANADA
dc.page.number618-626
dc.provenanceRealizada la curación de contenido 22/08/2024
dc.pubmedtypeJournal Article
dc.rights.accessRightsRestricted Access
dc.subjectAttention deficit disorder with hyperactivity
dc.subjectChild development
dc.subjectEnvironmental pollution
dc.subjectLongitudinal studies
dc.subjectMeta-analysis
dc.subjectNitrogen oxides
dc.subjectParticulate matter
dc.subjectProspective studies
dc.subject.decsContaminación ambiental
dc.subject.decsDesarrollo infantil
dc.subject.decsEstudios longitudinales
dc.subject.decsEstudios prospectivos
dc.subject.meshAir Pollution
dc.subject.meshAttention Deficit Disorder with Hyperactivity
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshEurope
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInhalation Exposure
dc.subject.meshNitrogen Dioxide
dc.subject.meshParticulate Matter
dc.subject.meshPregnancy
dc.subject.meshPrenatal Exposure Delayed Effects
dc.titleAir Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number29
dspace.entity.typePublication

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