Publication:
Cervical determinants of anal HPV infection and high-grade anal lesions in women: a collaborative pooled analysis.

dc.contributor.authorLin, Chunqing
dc.contributor.authorSlama, Jiri
dc.contributor.authorGonzalez, Paula
dc.contributor.authorGoodman, Marc T
dc.contributor.authorXia, Ningshao
dc.contributor.authorKreimer, Aimée R
dc.contributor.authorWu, Ting
dc.contributor.authorHessol, Nancy A
dc.contributor.authorShvetsov, Yurii
dc.contributor.authorOrtiz, Ana P
dc.contributor.authorGrinsztejn, Beatriz
dc.contributor.authorMoscicki, Anna-Barbara
dc.contributor.authorHeard, Isabelle
dc.contributor.authorDel Refugio González Losa, María
dc.contributor.authorKojic, Erna M
dc.contributor.authorSchim van der Loeff, Maarten F
dc.contributor.authorWei, Feixue
dc.contributor.authorLongatto-Filho, Adhemar
dc.contributor.authorMbulawa, Zizipho A
dc.contributor.authorPalefsky, Joel M
dc.contributor.authorSohn, Annette H
dc.contributor.authorHernandez, Brenda Y
dc.contributor.authorRobison, Katina
dc.contributor.authorSimpson, Steve
dc.contributor.authorConley, Lois J
dc.contributor.authorde Pokomandy, Alexandra
dc.contributor.authorvan der Sande, Marianne A B
dc.contributor.authorDube Mandishora, Racheal S
dc.contributor.authorVolpini, Lays P B
dc.contributor.authorPierangeli, Alessandra
dc.contributor.authorRomero, Byron
dc.contributor.authorWilkin, Timothy
dc.contributor.authorFranceschi, Silvia
dc.contributor.authorHidalgo-Tenorio, Carmen
dc.contributor.authorRamautarsing, Reshmie A
dc.contributor.authorPark, Ina U
dc.contributor.authorTso, Fernanda K
dc.contributor.authorGodbole, Sheela
dc.contributor.authorD'Hauwers, Kathleen W M
dc.contributor.authorSehnal, Borek
dc.contributor.authorMenezes, Lynette J
dc.contributor.authorHeráclio, Sandra A
dc.contributor.authorClifford, Gary M
dc.date.accessioned2023-01-25T13:35:04Z
dc.date.available2023-01-25T13:35:04Z
dc.date.issued2019-06-13
dc.description.abstractCervical cancer screening might contribute to the prevention of anal cancer in women. We aimed to investigate if routine cervical cancer screening results-namely high-risk human papillomavirus (HPV) infection and cytohistopathology-predict anal HPV16 infection, anal high-grade squamous intraepithelial lesions (HSIL) and, hence, anal cancer. We did a systematic review of MEDLINE, Embase, and the Cochrane library for studies of cervical determinants of anal HPV and HSIL published up to Aug 31, 2018. We centrally reanalysed individual-level data from 13 427 women with paired cervical and anal samples from 36 studies. We compared anal high-risk HPV prevalence by HIV status, cervical high-risk HPV, cervical cytohistopathology, age, and their combinations, using prevalence ratios (PR) and 95% CIs. Among 3255 women with anal cytohistopathology results, PRs were similarly calculated for all anal HSIL and HPV16-positive anal HSIL. Cervical and anal HPV infections were highly correlated. In HIV-negative women, anal HPV16 prevalence was 41% (447/1097) in cervical HPV16-positive versus 2% (214/8663) in cervical HPV16-negative women (PR 16·5, 95% CI 14·2-19·2, p HPV-based cervical cancer screening programmes might help to stratify anal cancer risk, irrespective of HIV status. For targeted secondary anal cancer prevention in high-risk groups, HIV-negative women with cervical HPV16, especially those older than 45 years, have a similar anal cancer risk profile to that of HIV-positive women. International Agency for Research on Cancer.
dc.identifier.doi10.1016/S1473-3099(19)30164-1
dc.identifier.essn1474-4457
dc.identifier.pmcPMC6656696
dc.identifier.pmid31204304
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656696/pdf
dc.identifier.unpaywallURLhttp://www.thelancet.com/article/S1473309919301641/pdf
dc.identifier.urihttp://hdl.handle.net/10668/14122
dc.issue.number8
dc.journal.titleThe Lancet. Infectious diseases
dc.journal.titleabbreviationLancet Infect Dis
dc.language.isoen
dc.organizationHospital Universitario Virgen de las Nieves
dc.page.number880-891
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, N.I.H., Extramural
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.pubmedtypeSystematic Review
dc.rights.accessRightsopen access
dc.subject.meshAnus Neoplasms
dc.subject.meshEarly Detection of Cancer
dc.subject.meshFemale
dc.subject.meshGlobal Health
dc.subject.meshHIV Seropositivity
dc.subject.meshHuman papillomavirus 16
dc.subject.meshHumans
dc.subject.meshPapillomavirus Infections
dc.subject.meshPrevalence
dc.subject.meshUterine Cervical Neoplasms
dc.titleCervical determinants of anal HPV infection and high-grade anal lesions in women: a collaborative pooled analysis.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number19
dspace.entity.typePublication

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