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Iodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory effects.

dc.contributor.authorSoriguer, Federico
dc.contributor.authorGutiérrez-Repiso, Carolina
dc.contributor.authorRubio-Martin, Elehazara
dc.contributor.authorLinares, Francisca
dc.contributor.authorCardona, Isabel
dc.contributor.authorLópez-Ojeda, Jaime
dc.contributor.authorPacheco, Marta
dc.contributor.authorGonzález-Romero, Stella
dc.contributor.authorGarriga, Maria J.
dc.contributor.authorVelasco, Ines
dc.contributor.authorSantiago, Piedad
dc.contributor.authorGarcía-Fuentes, Eduardo
dc.contributor.authoraffiliation[Soriguer,F; González-Romero,S; García-Fuentes,E] Servicio de Endocrinología y Nutrición, Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Soriguer,F; Rubio-Martin,E] CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Málaga, Spain. [Gutiérrez-Repiso,C; Linares,F; Cardona,I; García-Fuentes,E] Fundación IMABIS, Málaga, Spain. [López-Ojeda,J; Pacheco, M] Servicio de Radiología, Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Garriga, MJ] Servicio de Análisis Clínicos, Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Velasco,I] Servicio de Obstetricia y Ginecología, Hospital de Riotinto, Huelva, Spain. [Santiago,P] Servicio de Endocrinología y Nutrición, Hospital General, Jaen, Spain. [García-Fuentes,E] CIBER Fisiopaptología de la Obesidad y Nutrición (CIBERobn), Málaga, Spain. Laboratorio de Investigación, Málaga, Spain.es
dc.contributor.funderThe present study was supported in part by grants from the Instituto de Salud Carlos III (CP04/00133). CIBER FisiopatologÍa de la Obesidad y NutriciÓn (CIBEROBN) and CIBER de Diabetes y Enfermedades MetabÓlicas Asociadas (CIBERDEM)are ISCIII projects.
dc.date.accessioned2013-07-10T11:26:53Z
dc.date.available2013-07-10T11:26:53Z
dc.date.issued2011-06
dc.description.abstractLittle information is available as to whether doses of iodide similar to those recommended in clinical practice for the prevention of iodine deficiency in pregnant women affect thyroid function. The aim of the present study was to analyse whether doses of iodide can affect thyroid function in adults, and evaluate its effect on plasma markers of oxidative stress, inflammation and acute-phase proteins. A total of thirty healthy volunteers (ten men and twenty women) with normal thyroid function were randomly assigned to three groups (n 10). Each group received a daily dose of 100, 200 or 300 μg of iodide in the form of KI for 6 months. Free tetraiodothyronine (FT4) levels at day 60 of the study were higher in the groups treated with 200 and 300 μg (P = 0·01), and correlated with the increase in urinary iodine (r 0·50, P = 0·007). This correlation lost its significance after adjustment for the baseline FT4. The baseline urinary iodine and FT4 correlated positively with the baseline glutathione peroxidase. On day 60, urinary iodine correlated with C-reactive protein (r 0·461, P = 0·018), and free triiodothyronine correlated with IL-6 (r - 0·429, P = 0·025). On day 60, the changes produced in urinary iodine correlated significantly with the changes produced in α1-antitrypsin (r 0·475, P = 0·014) and ceruloplasmin (r 0·599, P = 0·001). The changes in thyroid-stimulating hormone correlated significantly with the changes in α1-antitrypsin (r - 0·521, P = 0·005) and ceruloplasmin (r - 0·459, P = 0·016). In conclusion, the administration of an iodide supplement between 100 and 300 μg/d did not modify thyroid function in a population with adequate iodine intake. The results also showed a slight anti-inflammatory and antioxidative action of iodide.es
dc.description.versionYeses
dc.identifier.citationSoriguer F, Gutiérrez-Repiso C, Rubio-Martin E, Linares F, Cardona I, López-Ojeda J, et al. Iodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory effects. Br J Nutr. 2011;105 (12):1783-90.es
dc.identifier.doi10.1017/S0007114510005568
dc.identifier.essn1475-2662
dc.identifier.issn0007-1145
dc.identifier.pmid21262066
dc.identifier.urihttp://hdl.handle.net/10668/1210
dc.journal.titleBritish Journal of Nutrition
dc.language.isoen
dc.organizationAGS Norte de Huelva
dc.publisherCambridge University Presses
dc.relation.publisherversionhttp://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8286421&fulltextType=RA&fileId=S0007114510005568es
dc.rights.accessRightsopen access
dc.subjectIodinees
dc.subjectThyroid functiones
dc.subjectUrinary iodinees
dc.subjectAntioxidantses
dc.subjectMujeres Embarazadases
dc.subjectAdultoes
dc.subjectMarcadores biológicoses
dc.subjectEstrés Oxidativoes
dc.subjectInflamaciónes
dc.subjectProteínas de fase agudaes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Halogens::Iodinees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidantses
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Women::Pregnant Womenes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adultes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markerses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stresses
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammationes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Acute-Phase Proteinses
dc.titleIodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory effects.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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