Publication:
A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease.

dc.contributor.authorVarela-López, Alfonso
dc.contributor.authorBullón, Pedro
dc.contributor.authorRamírez-Tortosa, César L
dc.contributor.authorNavarro-Hortal, María D
dc.contributor.authorRobles-Almazán, María
dc.contributor.authorBullón, Beatriz
dc.contributor.authorCordero, Mario D
dc.contributor.authorBattino, Maurizio
dc.contributor.authorQuiles, José L
dc.date.accessioned2023-02-08T14:51:02Z
dc.date.available2023-02-08T14:51:02Z
dc.date.issued2020-05-14
dc.description.abstractIncreasing evidence connects periodontitis with a variety of systemic diseases, including metabolic syndrome, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). The proposal of this study was to evaluate the role of diets rich in saturated fat and cholesterol in some aspects of periodontal diseases in a lipopolysaccharide (LPS)-induced model of periodontal disease in rabbits and to assess the influence of a periodontal intervention on hyperlipidemia, atherosclerosis, and NAFLD progression to non-alcoholic steatohepatitis. Male rabbits were maintained on a commercial standard diet or a diet rich in saturated fat (3% lard w/w) and cholesterol (1.3% w/w) (HFD) for 40 days. Half of the rabbits on each diet were treated 2 days per week with intragingival injections of LPS from Porphyromonas gingivalis. Morphometric analyses revealed that LPS induced higher alveolar bone loss (ABL) around the first premolar in animals receiving standard diets, which was exacerbated by the HFD diet. A higher score of acinar inflammation in the liver and higher blood levels of triglycerides and phospholipids were found in HFD-fed rabbits receiving LPS. These results suggest that certain dietary habits can exacerbate some aspects of periodontitis and that bad periodontal health can contribute to dyslipidemia and promote NAFLD progression, but only under certain conditions.
dc.identifier.doi10.3390/nu12051405
dc.identifier.essn2072-6643
dc.identifier.pmcPMC7284766
dc.identifier.pmid32422858
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284766/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2072-6643/12/5/1405/pdf?version=1589426052
dc.identifier.urihttp://hdl.handle.net/10668/15585
dc.issue.number5
dc.journal.titleNutrients
dc.journal.titleabbreviationNutrients
dc.language.isoen
dc.organizationIBS
dc.pubmedtypeJournal Article
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNASH
dc.subjectatherogenic
dc.subjectatherosclerosis
dc.subjectnon-alcoholic fatty liver disease
dc.subjectperiodontal diseases
dc.subjectperiodontitis
dc.subjectrabbits
dc.subject.meshAlveolar Bone Loss
dc.subject.meshAnimals
dc.subject.meshCholesterol
dc.subject.meshDiet, High-Fat
dc.subject.meshDisease Models, Animal
dc.subject.meshLipopolysaccharides
dc.subject.meshMale
dc.subject.meshPeriodontal Diseases
dc.subject.meshPeriodontitis
dc.subject.meshPorphyromonas gingivalis
dc.subject.meshRabbits
dc.titleA Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number12
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
PMC7284766.pdf
Size:
2.82 MB
Format:
Adobe Portable Document Format