Publication: Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma.
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Identifiers
Date
2019-02-08
Authors
Pertesi, Maroulio
Vallee, Maxime
Wei, Xiaomu
Revuelta, Maria V
Galia, Perrine
Demangel, Delphine
Oliver, Javier
Foll, Matthieu
Chen, Siwei
Perrial, Emeline
Advisors
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Journal ISSN
Volume Title
Publisher
Springer Nature
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Abstract
Multiple myeloma (MM) is the third most common hematological malignancy, after Non-Hodgkin Lymphoma and Leukemia. MM is generally preceded by Monoclonal Gammopathy of Undetermined Significance (MGUS), and epidemiological studies have identified older age, male gender, family history, and MGUS as risk factors for developing MM.
Description
MeSH Terms
Exome
Exosome multienzyme ribonuclease complex
Female
Genetic predisposition to disease
Germ-line mutation
Humans
Multiple myeloma
Pedigree
Exome sequencing
Exosome multienzyme ribonuclease complex
Female
Genetic predisposition to disease
Germ-line mutation
Humans
Multiple myeloma
Pedigree
Exome sequencing
DeCS Terms
Complejo multienzimático de ribonucleasas del exosoma
Exoma
Femenino
Humanos
Linaje
Mieloma múltiple
Mutación de línea germinal
Predisposición genética a la enfermedad
Secuenciación del exoma
Exoma
Femenino
Humanos
Linaje
Mieloma múltiple
Mutación de línea germinal
Predisposición genética a la enfermedad
Secuenciación del exoma
CIE Terms
Keywords
Mieloma, Exoma, Female, Germline mutation
Citation
Pertesi M, Vallée M, Wei X, Revuelta MV, Galia P, Demangel D, et al. Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma. Leukemia. 2019 Sep;33(9):2324-2330