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Development of [18F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis

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dc.contributor.authorGarcía-Argüello, Segundo Francisco
dc.contributor.authorLopez-Lorenzo, Beatriz
dc.contributor.authorCornelissen, Bart
dc.contributor.authorSmith, Graham
dc.contributor.authoraffiliation[García-Argüello,SF] Centro de Investigaciones Médico-Sanitarias, Fundación General Universidad de Málaga, Málaga, Spain. [García-Argüello,SF] Grupo de Arteriosclerosis, Prevención Cardiovascular y Metabolismo, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Lopez-Lorenzo,B] Biomedicina, Investigación Traslacional y Nuevas Tecnologías en Salud, Universidad de Málaga, Málaga, Spain. [Lopez-Lorenzo,B] BIONAND-Centro Andaluz de Nanomedicina y Biotecnología (Junta de Andalucía—Universidad de Málaga), Málaga, Spain. [Cornelissen,B; Smith,G] Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Old Road Campus Research Building, Oxford, UK.
dc.date.accessioned2022-09-27T05:51:59Z
dc.date.available2022-09-27T05:51:59Z
dc.date.issued2020-08-06
dc.description.abstractInsufficient apoptosis is a recognised hallmark of cancer. A strategy to quantitatively measure apoptosis in vivo would be of immense value in both drug discovery and routine patient management. The first irreversible step in the apoptosis cascade is activation of the "executioner" caspase-3 enzyme to commence cleavage of key structural proteins. One strategy to measure caspase-3 activity is Positron Emission Tomography using isatin-5-sulfonamide radiotracers. One such radiotracer is [18F]ICMT-11, which has progressed to clinical application. This review summarises the design and development process for [18F]ICMT-11, suggesting potential avenues for further innovation.es_ES
dc.description.versionYeses_ES
dc.identifier.citationGarcía-Argüello SF, Lopez-Lorenzo B, Cornelissen B, Smith G. Development of [18F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis. Cancers. 2020 Aug 6;12(8):2191es_ES
dc.identifier.doi10.3390/cancers12082191es_ES
dc.identifier.essn2072-6694
dc.identifier.pmcPMC7465189
dc.identifier.pmid32781531es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4148
dc.journal.titleCancers
dc.language.isoen
dc.page.number16 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2072-6694/12/8/2191/htmes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsAcceso abiertoes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPositron emission tomographyes_ES
dc.subjectApoptosises_ES
dc.subjectCaspase-3es_ES
dc.subject[18F]ICMT-11es_ES
dc.subjectPyrimidoindolonees_ES
dc.subjectMichael acceptores_ES
dc.subjectNeoplasmses_ES
dc.subjectIsatines_ES
dc.subjectTomografía de emisión de positroneses_ES
dc.subjectCaspasa-3es_ES
dc.subjectNeoplasiases_ES
dc.subjectIsatinaes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Cysteine Proteases::Cysteine Endopeptidases::Caspases::Caspases, Effector::Caspase 3es_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Indoles::Isatines_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Radioisotope::Radionuclide Imaging::Tomography, Emission-Computed::Positron-Emission Tomographyes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::NADH, NADPH Oxidoreductases::Apoptosis Inducing Factores_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Sulfonamideses_ES
dc.subject.meshMedical Subject Headings::Diseases::Neoplasmses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Drug Discoveryes_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.titleDevelopment of [18F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosises_ES
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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