Publication: Prognosis value of biomarkers in severe sepsis and septic shock.
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Date
2015-03
Authors
de la Torre-Prados, MV
García-de la Torre, A
Escobar-Conesa, R
Pérez-Vacas, J
Puerto-Morlán, A
Cámara-Sola, E
García-Alcántara, A
Advisors
Journal Title
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Publisher
BioMed Central
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Abstract
Introduction The purpose of the study was to assess the prognosis value of pro-adrenomedullin (pADM), C-reactive protein (CRP) and procalcitonin (PCT), lactate (LT), albumin (ALB), cholesterol (CHOL), white blood cell (WBC) and severity score in patients with severe sepsis or septic shock.
Methods A prospective, observational study in adult patients with severe sepsis or septic shock in a polyvalent ICU. Demographics, severity scores (APACHE II and SOFA) and all of the biomarkers were
studied within 24+ hours from septic shock onset. Descriptive and comparative statistical analysis was performed using the statistical software packages SPSS v.15 and MedCalc® 9.2.1.0. Conclusion The protein pADM, LT and ALB showed good prognosis
accuracy when measured on admission of septic patients to the ICU.
Description
MeSH Terms
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, Septic
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Sepsis
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Albumins::C-Reactive Protein
Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospital Units::Intensive Care Units
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adrenomedullin
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Calcitonin
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Cytochromes::Cytochrome P-450 Enzyme System::Aryl Hydrocarbon Hydroxylases::Cytochrome P-450 CYP2B1
Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Cholestanes::Cholestenes::Cholesterol
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Hydroxy Acids::Lactates::Lactic Acid
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Arthropod Proteins::Insect Proteins::Drosophila Proteins
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Sepsis
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Albumins::C-Reactive Protein
Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospital Units::Intensive Care Units
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adrenomedullin
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Calcitonin
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Cytochromes::Cytochrome P-450 Enzyme System::Aryl Hydrocarbon Hydroxylases::Cytochrome P-450 CYP2B1
Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Cholestanes::Cholestenes::Cholesterol
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Hydroxy Acids::Lactates::Lactic Acid
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Arthropod Proteins::Insect Proteins::Drosophila Proteins
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
DeCS Terms
CIE Terms
Keywords
Choque séptico, Proteína C-reactiva, Unidades de cuidados intensivos, Adrenomedulina, Marcadores biológicos, Calcitonina, Citocromo P-450 CYP2B1, Colesterol, Ácido láctico, Proteínas de drosophila, Leucocitos, Pronóstico
Citation
de la Torre-Prados MV, García-de_la_Torre A, Escobar-Conesa R, Perez-Vacas J, Puerto-Morlán A, Cámara-Sola E, et al. Prognosis value of biomarkers in severe sepsis and septic shock. Crit Care. 2015;19(Suppl 1):P67