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Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO.

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2022-01-21

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Llop, Maria
Moreno, Mireia
Navarro-Compán, Victoria
Juanola, Xavier
de Miguel, Eugenio
Almodóvar, Raquel
Quintana, Eduardo Cuende
Sanz, Jesús Sanz
Beltrán, Emma
Montesinos, M Dolores Ruiz

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Abstract

To evaluate the influence of the disease activity on radiographic progression in axial spondyloarthritis (axSpA) patients treated with TNF inhibitors (TNFi). The study included 101 axSpA patients from the Spanish Register of Biological Therapy in Spondyloarthritides (REGISPONSERBIO), which had clinical data and radiographic assessment available. Patients were classified into 2 groups based on the duration of TNFi treatment at baseline: (i) long-term treatment (≥4 years) and (ii) no long-term treatment ( Radiographic progression was defined as an increase in ≥2 mSASSS units. At inclusion, approximately half of the patients (45.5%) were receiving long-term treatment with TNFi (≥4 years). In this group of subjects, a significant difference in averaged Ankylosing Spondylitis disease Activity Score (ASDAS) across follow-up was found between progressors and non-progressors (2.33 vs 1.76, p=0.027, respectively). In patients not under long-term TNFi treatment (54.5%) though, no significant ASDAS differences were observed between progressors and non-progressors until the third year of follow-up. Furthermore, no significant differences were found in progression status, when disease activity was measured by Bath Ankylosing spondylitis Disease Activity Index (BASDAI) and C reactive protein (CRP). Patients on long-term TNFi treatment with a mean sustained low disease activity measures by ASDAS presented lower radiographic progression than those with active disease.

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MeSH Terms

Axial Spondyloarthritis
Disease Progression
Humans
Severity of Illness Index
Spine
Spondylarthritis
Spondylitis, Ankylosing
Tumor Necrosis Factor Inhibitors

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Keywords

Biological therapies, Inflammation, Outcome measures, Radiology, Spondyloarthritis

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