Publication: Adherence to mediterranean diet and the risk of differentiated thyroid cancer in a European cohort: The EPIC study.
Loading...
Identifiers
Date
2022-08-09
Authors
Llaha, Fjorida
Cayssials, Valerie
Farras, Marta
Agudo, Antonio
Sandström, Maria
Eriksen, Anne Kirstine
Tjønneland, Anne
Boutron-Ruault, Marie-Christine
Laouali, Nasser
Truong, Therese
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Research Foundation
Abstract
The Mediterranean diet (MD) has been proposed as a healthy diet with a potential to lower the incidence of several types of cancer, but there is no data regarding thyroid cancer (TC). We investigated the association between MD adherence, and its components, and the differentiated TC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Over 450,000 men and women from nine European countries were followed up for a mean of 14.1 years, during which 712 differentiated TC cases were identified. Adherence to MD was estimated using the relative MD (rMED) score, an 18-point scale including alcohol, and the adapted rMED (arMED) score, a 16-point scale excluding alcohol. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors. Adherence to the arMED score was not associated with the risk of differentiated TC (HRhigh vs. low adherence = 0.94, 95% CI: 0.70-1.25; p-trend 0.27), while a suggestive, but non-statistically significant inverse relationship was observed with rMED (HRhigh vs. low adherence = 0.88, 95% CI: 0.68-1.14; p-trend 0.17). Low meat (HRlow vs. high meat intake = 0.81, 95% CI: 0.67-0.99; p-trend = 0.04) and moderate alcohol (HRmoderate vs. non-moderate intake = 0.88, 95% CI: 0.75-1.03) intake were related with lower differentiated TC risk. Our study shows that a high adherence to MD is not strongly related to differentiated TC risk, although further research is required to confirm the impact of MD and, especially, meat intake in TC risk.
Description
MeSH Terms
Thyroid Neoplasms
Confidence Intervals
Diet, Healthy
Diet, Mediterranean
Prospective Studies
Confidence Intervals
Diet, Healthy
Diet, Mediterranean
Prospective Studies
DeCS Terms
Dieta Mediterránea
Estudios prospectivos
Intervalos de confianza
Neoplasias de la tiroides
Estudios prospectivos
Intervalos de confianza
Neoplasias de la tiroides
CIE Terms
Keywords
EPIC study, Mediterranean diet (MD), cohort, intake, meat, thyroid cancer (TC)
Citation
Llaha F, Cayssials V, Farràs M, Agudo A, Sandström M, Eriksen AK, et al. Adherence to mediterranean diet and the risk of differentiated thyroid cancer in a European cohort: The EPIC study. Front Nutr. 2022 Sep 2;9:982369.