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Exosomes: Their Role in Pathogenesis, Diagnosis and Treatment of Diseases.

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dc.contributor.authorAheget, Houssam
dc.contributor.authorMazini, Loubna
dc.contributor.authorMartin, Francisco
dc.contributor.authorBelqat, Boutaïna
dc.contributor.authorMarchal, Juan Antonio
dc.contributor.authorBenabdellah, Karim
dc.contributor.funderConsejería de Economía, Conocimiento, Empresas y Universidad de la Junta de Andalucía
dc.contributor.funderJunta de Andalucia Health and Families Department
dc.contributor.funderNational Center for Scientific and Technical Research (CNRST)
dc.contributor.funderMohammed VI Polytechnic University of Morocco
dc.contributor.funderEuropean Regional Development Fund (FEDER)
dc.contributor.funderMinistry of Science, Innovation and Universities
dc.contributor.funderChair of “Doctors Galera-Requena in cancer
dc.contributor.funderCECEyU and CSyF of the Junta de Andalucía FEDER/European Cohesion Fund (FSE)
dc.date.accessioned2023-02-09T10:39:11Z
dc.date.available2023-02-09T10:39:11Z
dc.date.issued2020-12-24
dc.description.abstractExosomes are lipid bilayer particles released from cells into their surrounding environment. These vesicles are mediators of near and long-distance intercellular communication and affect various aspects of cell biology. In addition to their biological function, they play an increasingly important role both in diagnosis and as therapeutic agents. In this paper, we review recent literature related to the molecular composition of exosomes, paying special attention to their role in pathogenesis, along with their application as biomarkers and as therapeutic tools. In this context, we analyze the potential use of exosomes in biomedicine, as well as the limitations that preclude their wider application.
dc.description.sponsorshipThis study was funded by the Spanish ISCIII Health Research Fund and the European Regional Development Fund (FEDER) through research grants PI12/01097, PI15/02015, PI18/00337 (F.M.), PIE16-00045 (J.A.M.), DTS19/00145 (J.A.M.) and PI18/00330 (K.B.). The study was also supported by the Ministry of Science, Innovation and Universities (MICIU, RTI2018-101309-B-C22, FEDER funds), by the Consejería de Economía, Conocimiento, Empresas y Universidad de la Junta de Andalucía (SOMM17/6109/UGR, FEDER Funds), the Chair of “Doctors Galera-Requena in cancer stem cell research” (CMC-CTS963) and the Junta de Andalucia Health and Families Department (CARTPI-0001-201). The CECEyU and CSyF of the Junta de Andalucía FEDER/European Cohesion Fund (FSE) provided the following research grants: 2016000073391-TRA, 2016000073332-TRA, PI57069 and PAIDI-Bio326 (F.M.) and PI-0014-2016 (K.B.). K.B. was also on a Nicolas Monardes Regional Ministry of Health contract (0006/2018). H.A. held a Research Excellence PhD Fellowship (2UAE2020) from the National Center for Scientific and Technical Research (CNRST). L.M. was supported by the Mohammed VI Polytechnic University of Morocco
dc.description.versionsi
dc.identifier.citationAheget H, Mazini L, Martin F, Belqat B, Marchal JA, Benabdellah K. Exosomes: Their Role in Pathogenesis, Diagnosis and Treatment of Diseases. Cancers (Basel). 2020 Dec 30;13(1):84.
dc.identifier.doi10.3390/cancers13010084
dc.identifier.issn2072-6694
dc.identifier.pmcPMC7795854
dc.identifier.pmid33396739
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795854/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2072-6694/13/1/84/pdf?version=1609739886
dc.identifier.urihttp://hdl.handle.net/10668/16914
dc.issue.number1
dc.journal.titleCancers
dc.journal.titleabbreviationCancers (Basel)
dc.language.isoen
dc.organizationCentro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica-GENYO
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.publisherMDPI AG
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
dc.relation.projectIDPI12/01097
dc.relation.projectIDPI15/02015
dc.relation.projectIDPI18/00337
dc.relation.projectIDPIE16-00045
dc.relation.projectIDDTS19/00145
dc.relation.projectIDPI18/00330
dc.relation.projectIDRTI2018-101309-B-C22
dc.relation.projectIDSOMM17/6109/UGR, FEDER Funds
dc.relation.projectIDCMC-CTS963
dc.relation.projectIDCARTPI-0001-201
dc.relation.projectID2016000073391-TRA
dc.relation.projectID2016000073332-TRA
dc.relation.projectIDPI57069
dc.relation.projectIDPAIDI-Bio326
dc.relation.projectIDPI-0014-2016
dc.relation.projectID0006/2018
dc.relation.publisherversionhttps://www.mdpi.com/resolver?pii=cancers13010084
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectcancer pathogenesis
dc.subjectdiagnostics
dc.subjectexosomes
dc.subjectmolecular composition
dc.subjecttherapeutics
dc.subject.decsBiomarcadores
dc.subject.decsComunicación celular
dc.subject.decsExosomas
dc.subject.decsMembrana dobles de lípidos
dc.subject.meshExosomes
dc.subject.meshLipid Bilayers
dc.subject.meshCell communication
dc.subject.meshBiomarkers
dc.titleExosomes: Their Role in Pathogenesis, Diagnosis and Treatment of Diseases.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number13
dspace.entity.typePublication

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