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Heterogeneity in Response to MCT and Psychoeducation: A Feasibility Study Using Latent Class Mixed Models in First-Episode Psychosis.

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dc.contributor.authorFerrer-Quintero, Marta
dc.contributor.authorFernandez, Daniel
dc.contributor.authorLopez-Carrilero, Raquel
dc.contributor.authorDiaz-Cutraro, Luciana
dc.contributor.authorVerdaguer-Rodriguez, Marina
dc.contributor.authorGarcia-Mieres, Helena
dc.contributor.authorHuerta-Ramos, Elena
dc.contributor.authorGomez-Benito, Juana
dc.contributor.authorPelaez, Trini
dc.contributor.authorBirules, Irene
dc.contributor.authorBarajas, Ana
dc.contributor.authorPousa, Esther
dc.contributor.authorBarrigon, Marisa
dc.contributor.authorGutierrez-Zotes, Alfonso
dc.contributor.authorGrasa, Eva
dc.contributor.authorRuiz-Delgado, Isabel
dc.contributor.authorLorente-Rovira, Esther
dc.contributor.authorCid, Jordi
dc.contributor.authorOchoa, Susana
dc.contributor.funderInstituto de Salud Carlos III, Spanish Government
dc.contributor.funderFondo Europeo de Desarrollo Regional (FEDER)
dc.contributor.funderProgress and Health Foundation of the Andalusian Regional Ministry of Health
dc.contributor.funderAgencia Estatal de Investigación (AEI, Spain)
dc.contributor.funderMinisterio de Ciencia e Innovación (Spain)
dc.contributor.groupOn Behalf Of The Spanish Metacognition Study Group,
dc.date.accessioned2023-05-03T13:54:54Z
dc.date.available2023-05-03T13:54:54Z
dc.date.issued2022-10-28
dc.description.abstractMetacognitive training (MCT) is an effective treatment for psychosis. Longitudinal trajectories of treatment response are unknown but could point to strategies to maximize treatment efficacy during the first episodes. This work aims to explore the possible benefit of using latent class mixed models (LCMMs) to understand how treatment response differs between metacognitive training and psychoeducation. We conducted LCMMs in 28 patients that received MCT and 34 patients that received psychoeducation. We found that MCT is effective in improving cognitive insight in all patients but that these effects wane at follow-up. In contrast, psychoeducation does not improve cognitive insight, and may increase self-certainty in a group of patients. These results suggest that LCMMs are valuable tools that can aid in treatment prescription and in predicting response to specific treatments.
dc.description.sponsorshipThis study was funded by the Instituto de Salud Carlos III, Spanish Government (PI11/01347, PI14/00044, and PI18/00212); the Fondo Europeo de Desarrollo Regional (FEDER), Health Department of Catalonia, PERIS call (SLT006/17/00231); Progress and Health Foundation of the Andalusian Regional Ministry of Health (PI-0634/2011 and PI-0193/2014); Obra Social La Caixa (RecerCaixa call 2013), Obra Social Sant Joan de Déu, BML (RTI2018-100927-J-I00) administered by Ministerio de Ciencia e Innovación (MCI, Spain), by the Agencia Estatal de Investigación (AEI, Spain), and by the European Regional Development Fund (FEDER, EU); Daniel Fernández has been supported by grant 2017 SGR 622 (GRBIO) administered by the Departament d’Economia i Coneixement de la Generalitat de Catalunya (Spain) and by the Ministerio de Ciencia e Innovación (Spain) [PID2019104830RB-I00/ DOI (AEI): 10.13039/501100011033]; and CIBER, Consorcio Centro de Investigación Biomédica en Red, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación.
dc.description.versionSi
dc.identifier.citationFerrer-Quintero M, Fernández D, López-Carrilero R, Díaz-Cutraro L, Verdaguer-Rodríguez M, García-Mieres H, et al. Heterogeneity in Response to MCT and Psychoeducation: A Feasibility Study Using Latent Class Mixed Models in First-Episode Psychosis. Healthcare (Basel). 2022 Oct 28;10(11):2155
dc.identifier.doi10.3390/healthcare10112155
dc.identifier.issn2227-9032
dc.identifier.pmcPMC9691095
dc.identifier.pmid36360496
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9691095/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2227-9032/10/11/2155/pdf?version=1668096813
dc.identifier.urihttp://hdl.handle.net/10668/21007
dc.issue.number11
dc.journal.titleHealthcare (Basel, Switzerland)
dc.journal.titleabbreviationHealthcare (Basel)
dc.language.isoen
dc.organizationHospital Universitario Regional de Málaga
dc.organizationHospital Universitario Virgen del Rocío
dc.page.number13
dc.provenanceRealizada la curación de contenido 14/02/2025
dc.publisherMDPI
dc.pubmedtypeJournal Article
dc.relation.projectIDPI11/01347
dc.relation.projectIDPI14/00044
dc.relation.projectIDPI-0634/2011
dc.relation.projectID10.13039/501100011033
dc.relation.publisherversionhttps://www.mdpi.com/resolver?pii=healthcare10112155
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFirst-episode psychosis
dc.subjectLatent class mixed models
dc.subjectMetacognition
dc.subjectMetacognitive training
dc.subjectPsychoeducation
dc.subjectSocial cognition
dc.subject.decsEstudios de seguimiento
dc.subject.decsResultado del tratamiento
dc.subject.decsTrastornos psicóticos
dc.subject.decsMetacognición
dc.subject.meshFollow-Up Studies
dc.subject.meshPsychotic Disorders
dc.subject.meshTreatment Outcome
dc.subject.meshMetacognition
dc.titleHeterogeneity in Response to MCT and Psychoeducation: A Feasibility Study Using Latent Class Mixed Models in First-Episode Psychosis.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication

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