Publication:
Impact of obesity-related genes in Spanish population

dc.contributor.authorMartínez-García, Fernando
dc.contributor.authorMansego, María L.
dc.contributor.authorRojo-Martínez, Gemma
dc.contributor.authorDe Marco-Solar, Griselda
dc.contributor.authorMorcillo, Sonsoles
dc.contributor.authorSoriguer, Federico
dc.contributor.authorRedón, Josep
dc.contributor.authorPineda Alonso, Monica
dc.contributor.authorMartín-Escudero, Juan C.
dc.contributor.authorCooper, Richard S.
dc.contributor.authorChaves, Felipe J.
dc.contributor.authoraffiliation[Martínez-García,F; Redón,J] Hypertension Clinic, Hospital Clínico Universitario and INCLIVA, University of Valencia, Valencia, Spain. [Martínez-García,F; Redón,J] CIBER 03/06 Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Minister of Health, Santiago de Compostela, Spain. [Mansego,ML; Marco-Solar,GD; Chaves,FJ] Genotyping and Genetic Diagnosis Unit, Hospital Clínico Research Foundation and INCLIVA, Valencia, Spain. [Mansego,ML; Rojo-Martínez,G; Marco-Solar,GD; Morcillo,S; Soriguer,F; Chaves,FJ] CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona,Spain. [Rojo-Martínez,G; Morcillo,S; Soriguer,F] Endocrinology and nutrition service, Carlos Haya Universitary Hospital, Málaga, Spain. [Pineda Alonso,M; Martín-Escudero,JC] Internal Medicine, Rio Hortega Hospital, University of Valladolid, Valladolid, Spain. [Cooper,RS] Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, IL, USA. [Redón,J] Internal Medicine, Hospital Clínico, Valencia, Spain.es
dc.contributor.funderThis work was supported by CIBER of Diabetes and metabolic diseases (CIBERDEM) and CIBER obesity and nutrition (CIBEROB). CIBERDEM and CIBEROBN are initiatives of the "Fondo de Investigaciones Sanitarias"; INGENFRED (Ref. CIBER-02-08-2009) grant from CIBERDEM; PI070497 from the "Fondo de Investigaciones Sanitarias"; ACOMP/2009/201 and PROMETEO/2009/029 from the Valencian Government; SAF2005-02883 from Ministerio de Educacion y Ciencia; P06-CTS-01684 from Andalusian Governement; Gema Rojo-Martinez [CP06/00133], and F. Javier Chaves [FIS01/3047] are contracted by the Health Institute Carlos III.
dc.date.accessioned2014-02-14T12:07:07Z
dc.date.available2014-02-14T12:07:07Z
dc.date.issued2013-11-23
dc.descriptionJournal Article; Research Support, Non-U.S. Gov't;es
dc.description.abstractBackground: The objective was to investigate the association between BMI and single nucleotide polymorphisms previously identified of obesity-related genes in two Spanish populations. Forty SNPs in 23 obesity-related genes were evaluated in a rural population characterized by a high prevalence of obesity (869 subjects, mean age 46 yr, 62% women, 36% obese) and in an urban population (1425 subjects, mean age 54 yr, 50% women, 19% obese). Genotyping was assessed by using SNPlex and PLINK for the association analysis. Results: Polymorphisms of the FTO were significantly associated with BMI, in the rural population (beta 0.87, p-value <0.001). None of the other SNPs showed significant association after Bonferroni correction in the two populations or in the pooled analysis. A weighted genetic risk score (wGRS) was constructed using the risk alleles of the Tag-SNPs with a positive Beta parameter in both populations. From the first to the fifth quintile of the score, the BMI increased 0.45 kg/m2 in Hortega and 2.0 kg/m2 in Pizarra. Overall, the obesity predictive value was low (less than 1%). Conclusion: The risk associated with polymorphisms is low and the overall effect on BMI or obesity prediction is minimal. A weighted genetic risk score based on genes mainly acting through central nervous system mechanisms was associated with BMI but it yields minimal clinical prediction for the obesity risk in the general population.es
dc.description.versionYeses
dc.identifier.citationMartínez-García F, Mansego ML, Rojo-Martínez G, De Marco-Solar G, Morcillo S, Soriguer F, et al. Impact of obesity-related genes in Spanish population. BMC Genet. 2013; 14:111es
dc.identifier.doi10.1186/1471-2156-14-111
dc.identifier.essn1471-2156
dc.identifier.pmid24267414
dc.identifier.urihttp://hdl.handle.net/10668/1502
dc.journal.titleBMC genetics
dc.language.isoen
dc.publisherBioMed Centrales
dc.relation.publisherversionhttp://www.biomedcentral.com/1471-2156/14/111/abstractes
dc.rights.accessRightsopen access
dc.subjectObesityes
dc.subjectGeneticses
dc.subjectFTO genees
dc.subjectGenetic scorees
dc.subjectEspañaes
dc.subjectObesidades
dc.subjectGenéticaes
dc.subjectÍndice de masa corporales
dc.subjectEstudio de asociación del genoma completoes
dc.subjectPolimorfismo de nucleótido simplees
dc.subjectAndalucíaes
dc.subject.meshMedical Subject Headings::Geographicals::Geographic Locations::Europe::Spaines
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adultes
dc.subject.meshMedical Subject Headings::Check Tags::Malees
dc.subject.meshMedical Subject Headings::Check Tags::Femalees
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesityes
dc.subject.meshMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Biometry::Anthropometry::Body Mass Indexes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Genome-Wide Association Studyes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotidees
dc.titleImpact of obesity-related genes in Spanish populationes
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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