Publication:
Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care.

dc.contributor.authorBreiteneder, Heimo
dc.contributor.authorDiamant, Zuzana
dc.contributor.authorEiwegger, Thomas
dc.contributor.authorFokkens, Wytske J
dc.contributor.authorTraidl-Hoffmann, Claudia
dc.contributor.authorNadeau, Kari
dc.contributor.authorO'Hehir, Robyn E
dc.contributor.authorO'Mahony, Liam
dc.contributor.authorPfaar, Oliver
dc.contributor.authorTorres, Maria J
dc.contributor.authorWang, De Yun
dc.contributor.authorZhang, Luo
dc.contributor.authorAkdis, Cezmi A
dc.date.accessioned2023-01-25T13:33:10Z
dc.date.available2023-01-25T13:33:10Z
dc.date.issued2019-06-04
dc.description.abstractThe specialties of allergy and clinical immunology have entered the era of precision medicine with the stratification of diseases into distinct disease subsets, specific diagnoses, and targeted treatment options, including biologicals and small molecules. This article reviews recent developments in research and patient care and future trends in the discipline. The section on basic mechanisms of allergic diseases summarizes the current status and defines research needs in structural biology, type 2 inflammation, immune tolerance, neuroimmune mechanisms, role of the microbiome and diet, environmental factors, and respiratory viral infections. In the section on diagnostic challenges, clinical trials, precision medicine and immune monitoring of allergic diseases, asthma, allergic and nonallergic rhinitis, and new approaches to the diagnosis and treatment of drug hypersensitivity reactions are discussed in further detail. In the third section, unmet needs and future research areas for the treatment of allergic diseases are highlighted with topics on food allergy, biologics, small molecules, and novel therapeutic concepts in allergen-specific immunotherapy for airway disease. Unknowns and future research needs are discussed at the end of each subsection.
dc.identifier.doi10.1111/all.13851
dc.identifier.essn1398-9995
dc.identifier.pmcPMC6973012
dc.identifier.pmid31056763
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973012/pdf
dc.identifier.unpaywallURLhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.13851
dc.identifier.urihttp://hdl.handle.net/10668/13915
dc.issue.number12
dc.journal.titleAllergy
dc.journal.titleabbreviationAllergy
dc.language.isoen
dc.organizationIBIMA
dc.page.number2293-2311
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, N.I.H., Extramural
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.pubmedtypeReview
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectallergy
dc.subjectexposome
dc.subjectmicrobiome
dc.subjectneuroimmune
dc.subjectrespiratory viral infections
dc.subject.meshAllergens
dc.subject.meshDisease Susceptibility
dc.subject.meshEnvironment
dc.subject.meshEnvironmental Exposure
dc.subject.meshHealth Services Needs and Demand
dc.subject.meshHost-Pathogen Interactions
dc.subject.meshHumans
dc.subject.meshHypersensitivity
dc.subject.meshImmune Tolerance
dc.subject.meshImmunomodulation
dc.subject.meshInflammation
dc.subject.meshNeuroimmunomodulation
dc.subject.meshPatient Care
dc.subject.meshPrecision Medicine
dc.subject.meshQuality Improvement
dc.subject.meshResearch
dc.titleFuture research trends in understanding the mechanisms underlying allergic diseases for improved patient care.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number74
dspace.entity.typePublication
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