Publication:
Prevention of the renarrowing of coronary arteries using drug-eluting stents in the perioperative period: an update.

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Date

2010

Authors

Llau, Juan V
Ferrandis, Raquel
Sierra, Pilar
Gómez Luque, Aurelio

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Dove Medical Press. Auckland
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Abstract

The management of patients scheduled for surgery with a coronary stent, and receiving 1 or more antiplatelet drugs, has many controversies. The premature discontinuation of antiplatelet drugs substantially increases the risk of stent thrombosis (ST), myocardial infarction, and cardiac death, and surgery under an altered platelet function could also lead to an increased risk of bleeding in the perioperative period. Because of the conflict in the recommendations, this article reviews the current antiplatelet protocols after positioning a coronary stent, the evidence of increased risk of ST associated with the withdrawal of antiplatelet drugs and increased bleeding risk associated with its maintenance, the different perioperative antiplatelet protocols when patients are scheduled for surgery or need an urgent operation, and the therapeutic options if excessive bleeding occurs.

Description

Journal Article; Review;

MeSH Terms

Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hemorrhage::Blood Loss, Surgical
Medical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Coronary Disease::Coronary Thrombosis
Medical Subject Headings::Anatomy::Cardiovascular System::Blood Vessels::Arteries::Coronary Vessels
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Prostheses and Implants::Stents::Drug-Eluting Stents
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Cardiovascular Surgical Procedures::Cardiac Surgical Procedures::Myocardial Revascularization
Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Services::Patient Care::Perioperative Care
Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Services::Patient Care::Perioperative Period
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Piperazines
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Hematologic Agents::Platelet Aggregation Inhibitors
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiophenes
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiophenes::Thienopyridines::Ticlopidine
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols::Hydroxybenzoates::Salicylates::Aspirin

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Keywords

stent thrombosis, antiplatelet agents, aspirin, clopidogrel, surgical bleeding, perioperative management, Pérdida de Sangre Quirúrgica, Trombosis Coronaria, Stents Liberadores de Fármacos, Humanos, Revascularización Miocárdica, Atención Perioperativa, Periodo Perioperatorio, Piperazinas, Inhibidores de Agregación Plaquetaria, Tiofenos, Ticlopidina, Aspirina

Citation

Llau JV, Ferrandis R, Sierra P, Gómez-Luque A. Prevention of the renarrowing of coronary arteries using drug-eluting stents in the perioperative period: an update. Vasc Health Risk Manag; 6:855-67