Publication:
Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia.

dc.contributor.authorHolubiec, Mariana I
dc.contributor.authorRomero, Juan I
dc.contributor.authorSuárez, Juan
dc.contributor.authorPortavella, Manuel
dc.contributor.authorFernández-Espejo, Emilio
dc.contributor.authorBlanco, Eduardo
dc.contributor.authorGaleano, Pablo
dc.contributor.authorde Fonseca, Fernando Rodríguez
dc.date.accessioned2023-01-25T10:21:08Z
dc.date.available2023-01-25T10:21:08Z
dc.date.issued2018-07-29
dc.description.abstractNeonatal anoxia-ischemia (AI) particularly affects the central nervous system. Despite the many treatments that have been tested, none of them has proven to be completely successful. Palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) are acylethanolamides that do not bind to CB1 or CB2 receptors and thus they do not present cannabinoid activity. These molecules are agonist compounds of peroxisome proliferator-activator receptor alpha (PPARα), which modulates the expression of different genes that are related to glucose and lipid metabolism, inflammation, differentiation and proliferation. In the present study, we analyzed the effects that the administration of PEA or OEA, after a neonatal AI event, has over different areas of the hippocampus. To this end, 7-day-old rats were subjected to AI and then treated with vehicle, OEA (2 or 10 mg/kg) or PEA (2 or 10 mg/kg). At 30 days of age, animals were subjected to behavioral tests followed by immunohistochemical studies. Results showed that neonatal AI was associated with decreased locomotion, as well as recognition and spatial memory impairments. Furthermore, these deficits were accompanied with enhanced neuroinflammation and astrogliosis, as well as a decreased PPARα expression. PEA treatment was able to prevent neuroinflammation, reduce astrogliosis and preserve cognitive functions. These results indicate that the acylethanolamide PEA may play an important role in the mechanisms underlying neonatal AI, and it could be a good candidate for further studies regarding neonatal AI treatments.
dc.identifier.doi10.1007/s00213-018-4982-9
dc.identifier.essn1432-2072
dc.identifier.pmid30058012
dc.identifier.unpaywallURLhttps://repositori.udl.cat/bitstream/10459.1/65513/3/027681.pdf
dc.identifier.urihttp://hdl.handle.net/10668/12771
dc.issue.number10
dc.journal.titlePsychopharmacology
dc.journal.titleabbreviationPsychopharmacology (Berl)
dc.language.isoen
dc.organizationHospital Universitario Regional de Málaga
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number2929-2945
dc.pubmedtypeJournal Article
dc.rightsCC0 1.0 Universal
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.subjectAstrogliosis
dc.subjectMemory impairment
dc.subjectNeonatal anoxia-ischemia
dc.subjectNeuroinflammation
dc.subjectOleoylethanolamide
dc.subjectPalmitoylethanolamide
dc.subject.meshAmides
dc.subject.meshAnimals
dc.subject.meshDisease Models, Animal
dc.subject.meshEndocannabinoids
dc.subject.meshEthanolamines
dc.subject.meshFemale
dc.subject.meshGlucose
dc.subject.meshHippocampus
dc.subject.meshHypoxia-Ischemia, Brain
dc.subject.meshLipid Metabolism
dc.subject.meshLocomotion
dc.subject.meshOleic Acids
dc.subject.meshPPAR alpha
dc.subject.meshPalmitic Acids
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.subject.meshRecognition, Psychology
dc.subject.meshSpatial Memory
dc.titlePalmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia.
dc.typeresearch article
dc.type.hasVersionAM
dc.volume.number235
dspace.entity.typePublication
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