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One-Year Changes in Urinary Microbial Phenolic Metabolites and the Risk of Type 2 Diabetes-A Case-Control Study.

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dc.contributor.authorMarhuenda-Muñoz, María
dc.contributor.authorDomínguez-López, Inés
dc.contributor.authorLaveriano-Santos, Emily P
dc.contributor.authorParilli-Moser, Isabella
dc.contributor.authorRazquin, Cristina
dc.contributor.authorRuiz-Canela, Miguel
dc.contributor.authorBasterra-Gortari, Francisco Javier
dc.contributor.authorCorella, Dolores
dc.contributor.authorSalas-Salvadó, Jordi
dc.contributor.authorFitó, Montserrat
dc.contributor.authorLapetra, José
dc.contributor.authorArós, Fernando
dc.contributor.authorFiol, Miquel
dc.contributor.authorSerra-Majem, Lluis
dc.contributor.authorPintó, Xavier
dc.contributor.authorGómez-Gracia, Enrique
dc.contributor.authorRos, Emilio
dc.contributor.authorEstruch, Ramon
dc.contributor.authorLamuela-Raventós, Rosa M
dc.date.accessioned2023-05-03T13:47:01Z
dc.date.available2023-05-03T13:47:01Z
dc.date.issued2022-08-08
dc.description.abstractThe intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23−0.64]; p
dc.identifier.doi10.3390/antiox11081540
dc.identifier.issn2076-3921
dc.identifier.pmcPMC9405292
dc.identifier.pmid36009259
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405292/pdf
dc.identifier.unpaywallURLhttps://www.mdpi.com/2076-3921/11/8/1540/pdf?version=1660188009
dc.identifier.urihttp://hdl.handle.net/10668/20787
dc.issue.number8
dc.journal.titleAntioxidants (Basel, Switzerland)
dc.journal.titleabbreviationAntioxidants (Basel)
dc.language.isoen
dc.organizationSevilla
dc.pubmedtypeJournal Article
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMediterranean diet
dc.subjectPREDIMED study
dc.subjectbioactive compounds
dc.subjectcardiovascular
dc.subjectliquid chromatography
dc.subjectmass spectrometry
dc.subjectphytochemicals
dc.subjecturinary microbial phenolic metabolites
dc.titleOne-Year Changes in Urinary Microbial Phenolic Metabolites and the Risk of Type 2 Diabetes-A Case-Control Study.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number11
dspace.entity.typePublication

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