Publication:
Advanced imaging tools for childhood tuberculosis: potential applications and research needs.

dc.contributor.authorJain, Sanjay K
dc.contributor.authorAndronikou, Savvas
dc.contributor.authorGoussard, Pierre
dc.contributor.authorAntani, Sameer
dc.contributor.authorGomez-Pastrana, David
dc.contributor.authorDelacourt, Christophe
dc.contributor.authorStarke, Jeffrey R
dc.contributor.authorOrdonez, Alvaro A
dc.contributor.authorJean-Philippe, Patrick
dc.contributor.authorBrowning, Renee S
dc.contributor.authorPerez-Velez, Carlos M
dc.date.accessioned2023-02-09T09:36:09Z
dc.date.available2023-02-09T09:36:09Z
dc.date.issued2020-06-23
dc.description.abstractTuberculosis is the leading cause of death globally that is due to a single pathogen, and up to a fifth of patients with tuberculosis in high-incidence countries are children younger than 16 years. Unfortunately, the diagnosis of childhood tuberculosis is challenging because the disease is often paucibacillary and it is difficult to obtain suitable specimens, causing poor sensitivity of currently available pathogen-based tests. Chest radiography is important for diagnostic evaluations because it detects abnormalities consistent with childhood tuberculosis, but several limitations exist in the interpretation of such results. Therefore, other imaging methods need to be systematically evaluated in children with tuberculosis, although current data suggest that when available, cross-sectional imaging, such as CT, should be considered in the diagnostic evaluation for tuberculosis in a symptomatic child. Additionally, much of the understanding of childhood tuberculosis stems from clinical specimens that might not accurately represent the lesional biology at infection sites. By providing non-invasive measures of lesional biology, advanced imaging tools could enhance the understanding of basic biology and improve on the poor sensitivity of current pathogen detection systems. Finally, there are key knowledge gaps regarding the use of imaging tools for childhood tuberculosis that we outlined in this Personal View, in conjunction with a proposed roadmap for future research.
dc.identifier.doi10.1016/S1473-3099(20)30177-8
dc.identifier.essn1474-4457
dc.identifier.pmcPMC7606757
dc.identifier.pmid32589869
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606757/pdf
dc.identifier.unpaywallURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606757
dc.identifier.urihttp://hdl.handle.net/10668/15833
dc.issue.number11
dc.journal.titleThe Lancet. Infectious diseases
dc.journal.titleabbreviationLancet Infect Dis
dc.language.isoen
dc.organizationÁrea de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
dc.organizationAGS - Jerez, Costa Noroeste y Sierra de Cáidz
dc.page.numbere289-e297
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, N.I.H., Extramural
dc.pubmedtypeReview
dc.rights.accessRightsopen access
dc.subject.meshAdolescent
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshHumans
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshMass Chest X-Ray
dc.subject.meshMycobacterium tuberculosis
dc.subject.meshNucleic Acid Amplification Techniques
dc.subject.meshPositron Emission Tomography Computed Tomography
dc.subject.meshTomography, Emission-Computed, Single-Photon
dc.subject.meshTuberculin Test
dc.subject.meshTuberculosis, Pulmonary
dc.subject.meshUltrasonography
dc.titleAdvanced imaging tools for childhood tuberculosis: potential applications and research needs.
dc.typeresearch article
dc.type.hasVersionAM
dc.volume.number20
dspace.entity.typePublication
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