Publication:
Cutaneous and Vascular Deposits of 18F-NaF by PET/CT in the Follow-Up of Patients with Pseudoxanthoma Elasticum

dc.contributor.authorLillo, Eugenia
dc.contributor.authorGutierrez-Cardo, Antonio
dc.contributor.authorMurcia-Casas, Belen
dc.contributor.authorCarrillo-Linares, Juan Luis
dc.contributor.authorGarcia-Argüello, Francisco
dc.contributor.authorChicharo-de-Freitas, Reinaldo
dc.contributor.authorBaquero-Aranda, Isabel
dc.contributor.authorValdivielso, Pedro
dc.contributor.authorGarcia-Fernandez, Maria
dc.contributor.authorSanchez-Chaparro, Miguel Angel
dc.contributor.authoraffiliation[Lillo,E; Garcia-Argüello,F; Chicharo de Freitas,R] Molecular Imaging Unit, Centro de Investigaciones Médico Sanitarias (CIMES), Fundación General de la Universidad de Málaga, Málaga, Spain. [Gutierrez-Cardo,A] Nuclear Medicine Department, Regional Hospital, Malaga, Spain. [Gutierrez-Cardo,A; Carrillo-Linares,JL; Garcia-Argüello,F; Valdivielso,P; García-Fernández,M; Sánchez-Chaparro,MÁ] Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain. [Murcia-Casas,B; Carrillo-Linares,JL; Valdivielso,P; Sánchez-Chaparro,MÁ] Internal Medicine Unit, Virgen de la Victoria Hospital, Malaga, Spain. [Baquero-Aranda,I] Ophtalmology Unit, Virgen de la Victoria Hospital, Malaga, Spain. [Valdivielso,P; Sánchez-Chaparro,MÁ] Department of Medicine and Dermatology, University of Malaga, Malaga, Spain. [García-Fernández,M] Department of Human Physiology, University of Malaga, Malaga, Spain.
dc.contributor.funderFondo de Investigaciones Sanitarias (FIS)
dc.contributor.funderISCIII
dc.contributor.funderEuropean Regional Development Fund (FEDER, “A Way to Make Europe”)
dc.date.accessioned2022-12-13T11:37:43Z
dc.date.available2022-12-13T11:37:43Z
dc.date.issued2021-06-11
dc.description.abstractActive microcalcification of elastic fibers is a hallmark of pseudoxanthoma elasticum and it can be measured with the assessment of deposition of 18F-NaF using a PET/CT scan at the skin and vascular levels. It is not known whether this deposition changes over time in absence of specific therapy. We repeated in two years a PET/CT scan using 18F-NaF as a radiopharmaceutical in patients with the disease and compared the deposition at skin and vessel. Furthermore, calcium score values at the vessel wall were also assessed. Main results indicate in the vessel walls that calcification progressed in each patient; by contrast, the active microcalcification, measured and target-to-background ratio showed reduced active deposition. By contrast, at skin levels (neck and axillae) the uptake of the pharmaceutical remains unchanged. In conclusion, because calcification in the arterial wall is not specific for pseudoxanthoma elasticum condition, the measurement of the deposition of 18F-NaF in the neck might be potentially used as a surrogate marker in future trials for the disease.es_ES
dc.description.sponsorshipThis research was funded by Grant number PI16/01579 from Fondo de Investigaciones Sanitarias (FIS), ISCIII, European Regional Development Fund (FEDER, “A Way to Make Europe”) and funds from the CTS-159 Group, PAIDI.
dc.description.versionYeses_ES
dc.identifier.citationLillo E, Gutierrez-Cardo A, Murcia-Casas B, Carrillo-Linares JL, Garcia-Argüello F, Chicharo de Freitas R, et al. Cutaneous and Vascular Deposits of 18F-NaF by PET/CT in the Follow-Up of Patients with Pseudoxanthoma Elasticum. J Clin Med. 2021 Jun 11;10(12):2588es_ES
dc.identifier.doi10.3390/jcm10122588es_ES
dc.identifier.essn2077-0383
dc.identifier.pmcPMC8230828
dc.identifier.pmid34208205es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4491
dc.journal.titleJournal of Clinical Medicine
dc.language.isoen
dc.page.number7 p.
dc.provenanceRealizada la curación de contenido 27/03/2025
dc.publisherMDPIes_ES
dc.relation.projectIDCTS-159
dc.relation.projectIDPI16/01579
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/10/12/2588es_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPseudoxanthoma elasticumes_ES
dc.subjectInorganic pyrophosphatees_ES
dc.subjectMicrocalcificationes_ES
dc.subject18F-NaFes_ES
dc.subjectPET/CTes_ES
dc.subject.decsSeudoxantoma elástico
dc.subject.decsPirofosfatasa inorgánica
dc.subject.decsCalcinosis
dc.subject.decsFluoruro de sodio
dc.subject.decsTomografía computarizada por tomografía de emisión de positrones
dc.subject.decsTejido elástico
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Diagnostic Uses of Chemicals::Radiopharmaceuticalses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Tomography, X-Ray::Tomography, X-Ray Computedes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Metals, Alkaline Earth::Calciumes_ES
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Connective Tissue::Elastic Tissuees_ES
dc.subject.meshMedical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Hemostatic Disorders::Pseudoxanthoma Elasticumes_ES
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Calcium Metabolism Disorders::Calcinosises_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparationses_ES
dc.titleCutaneous and Vascular Deposits of 18F-NaF by PET/CT in the Follow-Up of Patients with Pseudoxanthoma Elasticumes_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Lillo_CutaneosAnd.pdf
Size:
832.82 KB
Format:
Adobe Portable Document Format
Description:
Artículo publicado