Publication: Cutaneous and Vascular Deposits of 18F-NaF by PET/CT in the Follow-Up of Patients with Pseudoxanthoma Elasticum
dc.contributor.author | Lillo, Eugenia | |
dc.contributor.author | Gutierrez-Cardo, Antonio | |
dc.contributor.author | Murcia-Casas, Belen | |
dc.contributor.author | Carrillo-Linares, Juan Luis | |
dc.contributor.author | Garcia-Argüello, Francisco | |
dc.contributor.author | Chicharo-de-Freitas, Reinaldo | |
dc.contributor.author | Baquero-Aranda, Isabel | |
dc.contributor.author | Valdivielso, Pedro | |
dc.contributor.author | Garcia-Fernandez, Maria | |
dc.contributor.author | Sanchez-Chaparro, Miguel Angel | |
dc.contributor.authoraffiliation | [Lillo,E; Garcia-Argüello,F; Chicharo de Freitas,R] Molecular Imaging Unit, Centro de Investigaciones Médico Sanitarias (CIMES), Fundación General de la Universidad de Málaga, Málaga, Spain. [Gutierrez-Cardo,A] Nuclear Medicine Department, Regional Hospital, Malaga, Spain. [Gutierrez-Cardo,A; Carrillo-Linares,JL; Garcia-Argüello,F; Valdivielso,P; García-Fernández,M; Sánchez-Chaparro,MÁ] Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain. [Murcia-Casas,B; Carrillo-Linares,JL; Valdivielso,P; Sánchez-Chaparro,MÁ] Internal Medicine Unit, Virgen de la Victoria Hospital, Malaga, Spain. [Baquero-Aranda,I] Ophtalmology Unit, Virgen de la Victoria Hospital, Malaga, Spain. [Valdivielso,P; Sánchez-Chaparro,MÁ] Department of Medicine and Dermatology, University of Malaga, Malaga, Spain. [García-Fernández,M] Department of Human Physiology, University of Malaga, Malaga, Spain. | |
dc.contributor.funder | Fondo de Investigaciones Sanitarias (FIS) | |
dc.contributor.funder | ISCIII | |
dc.contributor.funder | European Regional Development Fund (FEDER, “A Way to Make Europe”) | |
dc.date.accessioned | 2022-12-13T11:37:43Z | |
dc.date.available | 2022-12-13T11:37:43Z | |
dc.date.issued | 2021-06-11 | |
dc.description.abstract | Active microcalcification of elastic fibers is a hallmark of pseudoxanthoma elasticum and it can be measured with the assessment of deposition of 18F-NaF using a PET/CT scan at the skin and vascular levels. It is not known whether this deposition changes over time in absence of specific therapy. We repeated in two years a PET/CT scan using 18F-NaF as a radiopharmaceutical in patients with the disease and compared the deposition at skin and vessel. Furthermore, calcium score values at the vessel wall were also assessed. Main results indicate in the vessel walls that calcification progressed in each patient; by contrast, the active microcalcification, measured and target-to-background ratio showed reduced active deposition. By contrast, at skin levels (neck and axillae) the uptake of the pharmaceutical remains unchanged. In conclusion, because calcification in the arterial wall is not specific for pseudoxanthoma elasticum condition, the measurement of the deposition of 18F-NaF in the neck might be potentially used as a surrogate marker in future trials for the disease. | es_ES |
dc.description.sponsorship | This research was funded by Grant number PI16/01579 from Fondo de Investigaciones Sanitarias (FIS), ISCIII, European Regional Development Fund (FEDER, “A Way to Make Europe”) and funds from the CTS-159 Group, PAIDI. | |
dc.description.version | Yes | es_ES |
dc.identifier.citation | Lillo E, Gutierrez-Cardo A, Murcia-Casas B, Carrillo-Linares JL, Garcia-Argüello F, Chicharo de Freitas R, et al. Cutaneous and Vascular Deposits of 18F-NaF by PET/CT in the Follow-Up of Patients with Pseudoxanthoma Elasticum. J Clin Med. 2021 Jun 11;10(12):2588 | es_ES |
dc.identifier.doi | 10.3390/jcm10122588 | es_ES |
dc.identifier.essn | 2077-0383 | |
dc.identifier.pmc | PMC8230828 | |
dc.identifier.pmid | 34208205 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10668/4491 | |
dc.journal.title | Journal of Clinical Medicine | |
dc.language.iso | en | |
dc.page.number | 7 p. | |
dc.provenance | Realizada la curación de contenido 27/03/2025 | |
dc.publisher | MDPI | es_ES |
dc.relation.projectID | CTS-159 | |
dc.relation.projectID | PI16/01579 | |
dc.relation.publisherversion | https://www.mdpi.com/2077-0383/10/12/2588 | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.accessRights | open access | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Pseudoxanthoma elasticum | es_ES |
dc.subject | Inorganic pyrophosphate | es_ES |
dc.subject | Microcalcification | es_ES |
dc.subject | 18F-NaF | es_ES |
dc.subject | PET/CT | es_ES |
dc.subject.decs | Seudoxantoma elástico | |
dc.subject.decs | Pirofosfatasa inorgánica | |
dc.subject.decs | Calcinosis | |
dc.subject.decs | Fluoruro de sodio | |
dc.subject.decs | Tomografía computarizada por tomografía de emisión de positrones | |
dc.subject.decs | Tejido elástico | |
dc.subject.mesh | Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans | es_ES |
dc.subject.mesh | Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Diagnostic Uses of Chemicals::Radiopharmaceuticals | es_ES |
dc.subject.mesh | Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Tomography, X-Ray::Tomography, X-Ray Computed | es_ES |
dc.subject.mesh | Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Metals, Alkaline Earth::Calcium | es_ES |
dc.subject.mesh | Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Elastic Tissue | es_ES |
dc.subject.mesh | Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Hemostatic Disorders::Pseudoxanthoma Elasticum | es_ES |
dc.subject.mesh | Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Calcium Metabolism Disorders::Calcinosis | es_ES |
dc.subject.mesh | Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations | es_ES |
dc.title | Cutaneous and Vascular Deposits of 18F-NaF by PET/CT in the Follow-Up of Patients with Pseudoxanthoma Elasticum | es_ES |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dspace.entity.type | Publication |
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