Publication:
Validation of a new tool to assess health-related quality of life in psoriasis: the PSO-LIFE questionnaire.

dc.contributor.authorDauden, Esteban
dc.contributor.authorHerrera Acosta, Enrique
dc.contributor.authorPuig, Lluis
dc.contributor.authorSánchez-Carazo, José Luis
dc.contributor.authorToribio, Jaime
dc.contributor.authorCaloto, Ma Teresa
dc.contributor.authorNocea, Gonzalo
dc.contributor.authorRoset, Montse
dc.contributor.authorLara, Nuria
dc.contributor.authoraffiliation[Dauden,E] Department of Dermatology, Hospital Universitario de la Princesa, Madrid, Spain. [Herrera Acosta,E] Department of Dermatology, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Puig,Ll] Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. [Sánchez-Carazo,JL] Department of Dermatology, Hospital General de Valencia, Valencia, Spain. [Toribio,J] Department of Dermatology, CHU Santiago (Hospital Gil Casares), Santiago de Compostela, Spain. [Lara,N] IMS Health, Health Economics and Outcomes Research, Barcelona, Spain.es
dc.date.accessioned2012-12-17T12:27:50Z
dc.date.available2012-12-17T12:27:50Z
dc.date.issued2012-05-24
dc.descriptionClinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies;es
dc.description.abstractBACKGROUND Several questionnaires have been used to measure health related quality of life (HRQoL) in patients with psoriasis, few have been adapted for use in Spain; none of them was developed specifically for the Spanish population. The purpose of the study was to validate and assess the sensitivity to change of a new questionnaire to measure HRQOL in patients with psoriasis (PSO-LIFE). METHODS Observational, prospective, multicenter study performed in centers around Spain. Patients with active or inactive psoriasis completed the PSO-LIFE together with other Dermatology Quality of Life Index (DLQI) and Psoriasis Disability Index (PDI). A control group of patients with urticaria or atopic dermatitis was also included. Internal consistency and test-retest reliability of the PSO-LIFE were assessed by calculating Cronbach's alpha and Intraclass Correlation Coefficient (ICC). Validity was assessed by examining factorial structure, the capacity to discriminate between groups, and correlations with other measures. Sensitivity to change was measured using effect sizes. RESULTS The final sample included for analysis consisted of 304 patients and 56 controls. Mean (SD) age of psoriasis patients was 45.3 (14.5) years compared to 38.8 (14) years for controls (p < 0.01). Cronbach's alpha for the PSO-LIFE was 0.95 and test-retest reliability using the ICC was 0.98. Factor analysis showed the questionnaire to be unidimensional. Mean (SD) PSO-LIFE scores differed between patients with psoriasis and controls (64.9 [22.5] vs 69.4 [17.3]; p < 0.05), between those with active and inactive disease (57.4 [20.4] vs 76.4 [20.6]; p < 0.01), and between those with visible and non-visible lesions (63.0 [21.9] vs. 74.8 [23.9]; p < 0.01). The correlation between PSO-LIFE and PASI scores was moderate (r = -0.43) while correlations with DLQI and PDI dimensions ranged from moderate to high (between 0.4 and 0.8). Effect size on the PSO-LIFE in patients reporting 'much improved' health status at study completion was 1.01 (large effect size). CONCLUSIONS The present results provide substantial support for the reliability, validity, and responsiveness of the PSO-LIFE questionnaire in the population for which it was designed.es
dc.description.versionYeses
dc.identifier.citationDauden E, Herrera E, Puig L, Sánchez-Carazo JL, Toribio J, Caloto MT, et al. Validation of a new tool to assess health-related quality of life in psoriasis: the PSO-LIFE questionnaire. Health Qual Life Outcomes. 2012; 10(1):56es
dc.identifier.doi10.1186/1477-7525-10-56
dc.identifier.essn1477-7525
dc.identifier.pmid22624984
dc.identifier.urihttp://hdl.handle.net/10668/718
dc.journal.titleHealth and quality of life outcomes
dc.language.isoen
dc.publisherBioMed Centrales
dc.relation.publisherversionhttp://www.hqlo.com/content/10/1/56es
dc.rights.accessRightsopen access
dc.subjectAncianoes
dc.subjectAnciano de 80 o más Añoses
dc.subjectAnálisis de Varianzaes
dc.subjectEstudios de Seguimientoes
dc.subjectIndicadores de Saludes
dc.subjectVisita a Consultorio Médicoes
dc.subjectEvaluación de Resultado (Atención de Salud)es
dc.subjectPsicometríaes
dc.subjectInvestigación Cualitativaes
dc.subjectCalidad de Vidaes
dc.subjectReproducibilidad de Resultadoses
dc.subjectClase sociales
dc.subjectEspañaes
dc.subjectEstadísticas no Paramétricases
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Agedes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged::Aged, 80 and overes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variancees
dc.subject.meshMedical Subject Headings::Check Tags::Femalees
dc.subject.meshMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Follow-Up Studieses
dc.subject.meshMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Data Collection::Health Surveys::Health Status Indicatorses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Check Tags::Malees
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Agedes
dc.subject.meshMedical Subject Headings::Health Care::Health Services Administration::Organization and Administration::Professional Practice::Office Visitses
dc.subject.meshMedical Subject Headings::Health Care::Health Services Administration::Quality of Health Care::Outcome and Process Assessment (Health Care)::Outcome Assessment (Health Care)es
dc.subject.meshMedical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Skin Diseases, Papulosquamous::Psoriasises
dc.subject.meshMedical Subject Headings::Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Psychometricses
dc.subject.meshMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Science::Research::Empirical Research::Qualitative Researches
dc.subject.meshMedical Subject Headings::Humanities::Humanities::Philosophy::Life::Quality of Lifees
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Questionnaireses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Reproducibility of Resultses
dc.subject.meshMedical Subject Headings::Health Care::Population Characteristics::Socioeconomic Factors::Social Classes
dc.subject.meshMedical Subject Headings::Geographicals::Geographic Locations::Europe::Spaines
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Statistics, Nonparametrices
dc.titleValidation of a new tool to assess health-related quality of life in psoriasis: the PSO-LIFE questionnaire.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication
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