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Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer.

dc.contributor.authorMukama, Trasias
dc.contributor.authorFortner, Renée Turzanski
dc.contributor.authorKatzke, Verena
dc.contributor.authorHynes, Lucas Cory
dc.contributor.authorPetrera, Agnese
dc.contributor.authorHauck, Stefanie M
dc.contributor.authorJohnson, Theron
dc.contributor.authorSchulze, Matthias
dc.contributor.authorSchiborn, Catarina
dc.contributor.authorRostgaard-Hansen, Agnetha Linn
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOvervad, Kim
dc.contributor.authorPérez, María José Sánchez
dc.contributor.authorCrous-Bou, Marta
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorAmiano, Pilar
dc.contributor.authorArdanaz, Eva
dc.contributor.authorWatts, Eleanor L
dc.contributor.authorTravis, Ruth C
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorGrioni, Sara
dc.contributor.authorMasala, Giovanna
dc.contributor.authorSignoriello, Simona
dc.contributor.authorTumino, Rosario
dc.contributor.authorGram, Inger T
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorSartor, Hanna
dc.contributor.authorLundin, Eva
dc.contributor.authorIdahl, Annika
dc.contributor.authorHeath, Alicia K
dc.contributor.authorDossus, Laure
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorKaaks, Rudolf
dc.date.accessioned2023-05-03T13:26:15Z
dc.date.available2023-05-03T13:26:15Z
dc.date.issued2022-01-14
dc.description.abstractCA125 is the best available yet insufficiently sensitive biomarker for early detection of ovarian cancer. There is a need to identify novel biomarkers, which individually or in combination with CA125 can achieve adequate sensitivity and specificity for the detection of earlier-stage ovarian cancer. In the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we measured serum levels of 92 preselected proteins for 91 women who had blood sampled ≤18 months prior to ovarian cancer diagnosis, and 182 matched controls. We evaluated the discriminatory performance of the proteins as potential early diagnostic biomarkers of ovarian cancer. Nine of the 92 markers; CA125, HE4, FOLR1, KLK11, WISP1, MDK, CXCL13, MSLN and ADAM8 showed an area under the ROC curve (AUC) of ≥0.70 for discriminating between women diagnosed with ovarian cancer and women who remained cancer-free. All, except ADAM8, had shown at least equal discrimination in previous case-control comparisons. The discrimination of the biomarkers, however, was low for the lag-time of >9-18 months and paired combinations of CA125 with any of the 8 markers did not improve discrimination compared to CA125 alone. Using pre-diagnostic serum samples, this study identified markers with good discrimination for the lag-time of 0-9 months. However, the discrimination was low in blood samples collected more than 9 months prior to diagnosis, and none of the markers showed major improvement in discrimination when added to CA125.
dc.identifier.doi10.1038/s41416-021-01697-z
dc.identifier.essn1532-1827
dc.identifier.pmcPMC9042845
dc.identifier.pmid35031764
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9042845/pdf
dc.identifier.unpaywallURLhttps://www.nature.com/articles/s41416-021-01697-z.pdf
dc.identifier.urihttp://hdl.handle.net/10668/19522
dc.issue.number9
dc.journal.titleBritish journal of cancer
dc.journal.titleabbreviationBr J Cancer
dc.language.isoen
dc.organizationEscuela Andaluza de Salud Pública-EASP
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number1301-1309
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshADAM Proteins
dc.subject.meshBiomarkers, Tumor
dc.subject.meshBlood Proteins
dc.subject.meshCA-125 Antigen
dc.subject.meshCarcinoma, Ovarian Epithelial
dc.subject.meshCase-Control Studies
dc.subject.meshEarly Detection of Cancer
dc.subject.meshFemale
dc.subject.meshFolate Receptor 1
dc.subject.meshHumans
dc.subject.meshMembrane Proteins
dc.subject.meshOvarian Neoplasms
dc.subject.meshROC Curve
dc.titleProspective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number126
dspace.entity.typePublication
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